Patients with artificial joints: do they need antibiotic cover for dental treatment?

This study reviews whether patients with artificial joints need antibiotic cover for dental treatment. Generally in Australia the practice has developed of giving most patients with artificial joints antibiotic prophylaxis for a wide range of dental procedures. This is partly on anecdotal grounds, partly historical and partly for legal concerns. It has been encouraged by some guidelines. Scientifically, the risk and the benefit of each step in the process needs to be analysed. This review shows that the risk of an artificial joint becoming infected from a bacteraemia of oral origin is exceedingly low whereas the risk of an adverse reaction to the antibiotic prophylaxis is higher than the risk of infection. If all patients with artificial joints receive antibiotic prophylaxis then more will die from anaphylaxis than develop infections. Factors which balance the risk benefit are if the patient is seriously immunocompromised, if the joint prosthesis is failing or chronically inflamed and if the dental procedures, such as from extractions and deep periodontal scaling, produce high level bacteraemias. Recommendations to rationalize antibiotic prophylaxis for patients with artificial joints are presented.

[1]  I. Straznicky,et al.  Antibiotic prophylaxis for endocarditis: time to reconsider. , 2005, Australian dental journal.

[2]  R. Suuronen,et al.  Bacteremia after plate removal and tooth extraction. , 2004, International journal of oral and maxillofacial surgery.

[3]  R. Seymour,et al.  Antibiotic prophylaxis for patients with joint prostheses — still a dilemma for dental practitioners , 2003, British Dental Journal.

[4]  P. Holtom,et al.  Periprosthetic Total Hip Infection: Outcomes Using a Staging System , 2002, Clinical orthopaedics and related research.

[5]  R. Laskin,et al.  Infection in Total Knee Replacement: A Retrospective Review of 6489 Total Knee Replacements , 2001, Clinical orthopaedics and related research.

[6]  R. Laskin,et al.  The Knee Society Index of Severity for Failed Total Knee Arthroplasty: Development and Validation , 2001, Clinical orthopaedics and related research.

[7]  A. Goss,et al.  Antibiotic prescribing practices by South Australian general dental practitioners. , 2000, Australian dental journal.

[8]  I. Olsen,et al.  Anaerobic bacteremia and fungemia in patients undergoing endodontic therapy: an overview. , 1998, Annals of periodontology.

[9]  D. Hungerford,et al.  Total knee arthroplasty infections associated with dental procedures. , 1997, Clinical orthopaedics and related research.

[10]  J. Benjamin,et al.  Safety and efficacy of bilateral total knee arthroplasty. , 1997, The Journal of arthroplasty.

[11]  C. W. Whall Advisory statement. Antibiotic prophylaxis for dental patients with total joint replacements. American Dental Association; American Academy of Orthopaedic Surgeons. , 1997, Journal of the American Dental Association.

[12]  J. Lowry,et al.  Who decides on the need for antibiotic prophylaxis in patients with major arthroplasties requiring dental treatment: is it a joint responsibility? , 1997, Annals of the Royal College of Surgeons of England.

[13]  C. Nord,et al.  Effects of prophylactic administration of cefaclor on transient bacteremia after dental extraction , 1996, European Journal of Clinical Microbiology and Infectious Diseases.

[14]  K. Nakagawa,et al.  Factors affecting the occurrence of bacteremia associated with tooth extraction. , 1995, International journal of oral and maxillofacial surgery.

[15]  A. Kaneko,et al.  Intravenous administration of vancomycin is ineffective against bacteremia following tooth extraction. , 1995, The Tokai Journal of Experimental and Clinical Medicine.

[16]  M. Martín,et al.  Relation between mouth and haematogenous infection in total joint replacements , 1994, BMJ.

[17]  A. B. Prasad,et al.  British National Formulary , 1994 .

[18]  S. Levin PROPHYLACTIC ADMINISTRATION OF PENICILLINS FOR ENDOCARDITIS DOES NOT REDUCE THE INCIDENCE OF POSTEXTRACTION BACTEREMIA Hall G, Hedstrom SA, Heimdahl A, Nord CE. Clin Infect Dis. 1993;17: 188–94 , 1993 .

[19]  C E Nord,et al.  Prophylactic administration of penicillins for endocarditis does not reduce the incidence of postextraction bacteremia. , 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  C. Kowalski,et al.  Chemoprophylaxis of prosthetic joint patients during dental treatment: a decision-utility analysis. , 1991, Oral surgery, oral medicine, and oral pathology.

[21]  S. Schweitzer,et al.  Antibiotic prophylaxis for Dental Patients with Joint Prostheses? A Decision Analysis , 1990, International Journal of Technology Assessment in Health Care.

[22]  P. Söder,et al.  Detection and quantitation by lysis-filtration of bacteremia after different oral surgical procedures , 1990, Journal of clinical microbiology.

[23]  I. Gould,et al.  Prevention of late haematogenous infection in major prosthetic joints. , 1989, The Journal of antimicrobial chemotherapy.

[24]  E. Maderazo,et al.  Late infections of total joint prostheses. A review and recommendations for prevention. , 1988, Clinical orthopaedics and related research.

[25]  K. Pelz,et al.  Anaerobic bacteremia following tooth extraction and removal of osteosynthesis plates. , 1987, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[26]  I. B. Bender,et al.  Bacterial endocarditis: a consideration for physician and dentist. , 1984, Journal of the American Dental Association.

[27]  D. Ainscow,et al.  The risk of haematogenous infection in total joint replacements. , 1984, The Journal of bone and joint surgery. British volume.

[28]  G. Hunter,et al.  Failure in total knee arthroplasty: mechanisms, revisions, and results. , 1982, Clinical orthopaedics and related research.

[29]  C. W. Parker Allergic reactions in man. , 1982, Pharmacological reviews.

[30]  R. Law “British National Formulary” , 1966 .

[31]  A. Macgregor ORAL AND DENTAL DISEASES , 1948, The Ulster Medical Journal.

[32]  J. Jenny,et al.  Infections associated with dental procedures in total hip arthroplasty. , 1999, The Journal of bone and joint surgery. British volume.

[33]  Orthopaedic Surgeons Antibiotic prophylaxis for dental patients with total joint replacements. American Dental Association; American Academy of Orthopaedic Surgeons. , 1997, Journal of the Kansas Dental Association.

[34]  J. Billé,et al.  Antibiotic prophylaxis of experimental endocarditis after dental extractions. , 1988, Circulation.

[35]  Eric Simrod How important are dental procedures as a cause of infective endocarditis , 1985 .

[36]  J. Little The need for antibiotic coverage for dental treatment of patients with joint replacements. , 1983, Oral surgery, oral medicine, and oral pathology.

[37]  O. Idsøe,et al.  Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. , 1968, Bulletin of the World Health Organization.