Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens

In this paper we describe the relationship between antibodies to Necator americanus stage‐specific antigens and parasite burden in an endemically‐infected population in Papua New Guinea. Using an age‐structured analysis, we show that the correlation coefficient between levels of IgG against adult worm excretory‐secretory (ES) antigen and parasite burden declined significantly with host age from positive in younger hosts to significantly negative in older hosts. A trend towards similar patterns was present for anti‐larval IgG both pretreatment and after reinfection, and for anti‐ES IgM and anti‐ES IgE pretreatment. These patterns are consistent with a role for these isotypes in a protective immune response, although parasite‐induced immunosuppression may provide an alternate explanation. This is another demonstration of possibly protective responses to N. americanus infection.,

[1]  D. Pritchard,et al.  The specificity of the human IgE response to Necator americanus , 1995, Parasite immunology.

[2]  R. Quinnell,et al.  Immunity in humans to Necator americanus‐. IgE, parasite weight and fecundity , 1995, Parasite immunology.

[3]  D. Pritchard,et al.  Immunosuppressive proteins secreted by the gastrointestinal nematode parasite Heligmosomoides polygyrus. , 1994, International journal for parasitology.

[4]  R. Maizels,et al.  Immunological modulation and evasion by helminth parasites in human populations , 1993, Nature.

[5]  M. Woolhouse.  A theoretical framework for immune responses and predisposition to helminth infection , 1993, Parasite immunology.

[6]  D. Pritchard,et al.  Reinfection with hookworm after chemotherapy in Papua New Guinea , 1993, Parasitology.

[7]  D. Pritchard,et al.  The immunogenicity of hookworm (Necator americanus) acetylcholinesterase (AChE) in man , 1993, Parasite immunology.

[8]  M. Woolhouse.  A theoretical framework for the immunoepidemiology of helminth infection , 1992, Parasite immunology.

[9]  D. Pritchard,et al.  Isotypic variation in antibody responses in a community in Papua New Guinea to larval and adult antigens during infection, and following reinfection, with the hookworm Necator americanus , 1992, Parasite immunology.

[10]  R. Sturrock,et al.  On the use of age-intensity data to detect immunity to parasitic infections, with special reference to Schistosoma mansoni in Kenya , 1992, Parasitology.

[11]  D. Pritchard,et al.  Secretion of metalloproteases by living infective larvae of Necator americanus. , 1992, The Journal of parasitology.

[12]  D. Bundy,et al.  The relationship between Trichuris trichiura transmission intensity and the age-profiles of parasite-specific antibody isotypes in two endemic communities , 1992, Parasitology.

[13]  A. Capron,et al.  Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection , 1992, European journal of immunology.

[14]  D. Bundy,et al.  Age‐dependency of infection status and serum antibody levels in human whipworm (Trichuris trichiura) infection , 1991, Parasite immunology.

[15]  A. Simpson,et al.  Human IgE, IgG4 and resistance to reinfection with Schistosomahaematobium , 1991, Nature.

[16]  G. Medley,et al.  The regulation of gastrointestinal helminth populations. , 1990, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[17]  D. Pritchard,et al.  Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens , 1990, Parasitology.

[18]  R. Maizels,et al.  The antibody recognition profiles of humans naturally infected with Ascaris lumbricoides , 1989, Parasite immunology.

[19]  W. Rice.  ANALYZING TABLES OF STATISTICAL TESTS , 1989, Evolution; international journal of organic evolution.

[20]  D. Pritchard,et al.  Antigen expression during development of the human hookworm, Necator americanus (Nematoda) , 1987, Parasite immunology.

[21]  R. Anderson,et al.  The population dynamics and epidemiology of intestinal nematode infections. , 1986, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[22]  B. E. Matthews.  Skin penetration by Necator americanus larvae. , 1982, Zeitschrift fur Parasitenkunde.