The Effect of Fibrinolysis Inhibitors on the Ellagic Acid Activation of Hageman Factor in the Dog

Summary The administration of 10 ml/kg b.w. of a 10−4 M ellagic acid solution to dogs primed with saline (control group) caused a marked shortening of the silicone clotting time and a mild shortening of the glass clotting time whereas no changes in the euglobulin lysis time were noted. The administration of the compound to dogs primed with Trasylol (10,000 K.I.U./kg b.w.) failed to cause any change in the clotting times but caused instead a sharp inhibition of fibrinolysis. The administration of ellagic acid to dogs primed with EACA (0.3 g/kg b.w.) caused a shortening of the silicone and glass clotting times similar to that observed in the control group whereas fibrinolysis was not significantly inhibited. These data indicate that Trasylol inhibits Hageman factor activation by ellagic acid whereas EACA has no effect.