Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer
暂无分享,去创建一个
Sriganesh Srihari | Chao Liu | Benoît Gautier | Kum Kum Khanna | Mark A Ragan | Kim-Anh Lê Cao | M. Ragan | K. Khanna | P. Simpson | Samir Lal | S. Srihari | K. Lê Cao | Chao Liu | B. Gautier | Samir Lal | Peter T Simpson
[1] Hao Cai,et al. Individualized identification of disease-associated pathways with disrupted coordination of gene expression , 2016, Briefings Bioinform..
[2] Eytan Domany,et al. Pathway‐based personalized analysis of breast cancer expression data , 2015, Molecular oncology.
[3] A. Ashworth,et al. Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers. , 2015, Cancer discovery.
[4] E. Wang,et al. TUSC4 functions as a tumor suppressor by regulating BRCA1 stability. , 2015, Cancer research.
[5] A. Børresen-Dale,et al. A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer , 2014, Molecular oncology.
[6] Qiang Sun,et al. Individual-level analysis of differential expression of genes and pathways for personalized medicine , 2015, Bioinform..
[7] N. McGranahan,et al. Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer. , 2014, Cancer research.
[8] Lana X. Garmire,et al. A Novel Model to Combine Clinical and Pathway-Based Transcriptomic Information for the Prognosis Prediction of Breast Cancer , 2014, PLoS Comput. Biol..
[9] Taesung Park,et al. Personalized identification of altered pathways in cancer using accumulated normal tissue data , 2014, Bioinform..
[10] C. Greenwood,et al. Chromosome-breakage genomic instability and chromothripsis in breast cancer , 2014, BMC Genomics.
[11] G. Chenevix-Trench,et al. A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy , 2014, Nucleic acids research.
[12] D. Durocher,et al. Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions , 2014, Science.
[13] A. Venkitaraman. Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2 , 2014, Science.
[14] Ralph R. Weichselbaum,et al. DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy , 2014, Science Translational Medicine.
[15] F. D. D. Fagagna. A direct role for small non-coding RNAs in DNA damage response. , 2014 .
[16] D. Sheer,et al. The role of microhomology in genomic structural variation. , 2014, Trends in genetics : TIG.
[17] G. Mills,et al. Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair , 2014, Nature Communications.
[18] A. Venkitaraman. Tumour Suppressor Mechanisms in the Control of Chromosome Stability: Insights from BRCA2 , 2014, Molecules and cells.
[19] F. d’Adda di Fagagna. A direct role for small non-coding RNAs in DNA damage response. , 2014, Trends in cell biology.
[20] K. Cimprich,et al. Causes and consequences of replication stress , 2013, Nature Cell Biology.
[21] M. Debatisse,et al. Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells , 2013, Proceedings of the National Academy of Sciences.
[22] A. Aguilera,et al. Causes of genome instability. , 2013, Annual review of genetics.
[23] Roman Rouzier,et al. Genomic Instability: A Stronger Prognostic Marker Than Proliferation for Early Stage Luminal Breast Carcinomas , 2013, PloS one.
[24] Chris Sander,et al. The molecular diversity of Luminal A breast tumors , 2013, Breast Cancer Research and Treatment.
[25] N. McGranahan,et al. The causes and consequences of genetic heterogeneity in cancer evolution , 2013, Nature.
[26] David T. W. Jones,et al. Signatures of mutational processes in human cancer , 2013, Nature.
[27] T. Misteli,et al. Non‐coding RNAs in DNA damage and repair , 2013, FEBS letters.
[28] A. Nussenzweig,et al. End-joining, translocations and cancer , 2013, Nature Reviews Cancer.
[29] J. Reis-Filho,et al. Taxane benefit in breast cancer—a role for grade and chromosomal stability , 2013, Nature Reviews Clinical Oncology.
[30] Michal Sheffer,et al. Pathway-based personalized analysis of cancer , 2013, Proceedings of the National Academy of Sciences.
[31] A. D’Andrea,et al. Chromatin Remodeling at DNA Double-Strand Breaks , 2013, Cell.
[32] Jiri Bartek,et al. Replication stress links structural and numerical cancer chromosomal instability , 2013, Nature.
[33] Young Eun Choi,et al. Charity begins at home: non-coding RNA functions in DNA repair , 2013, Nature Reviews Molecular Cell Biology.
[34] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumours , 2013 .
[35] A. Vincent-Salomon,et al. Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. , 2012, Cancer research.
[36] A. Malkova,et al. Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations , 2012, PLoS genetics.
[37] F. Markowetz,et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups , 2012, Nature.
[38] H. Ulrich. Ubiquitin and SUMO in DNA repair at a glance , 2012, Journal of Cell Science.
[39] Qin Huang,et al. Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression , 2012, Nature Communications.
[40] Masaaki Oka,et al. Luminal A and luminal B (HER2 negative) subtypes of breast cancer consist of a mixture of tumors with different genotype , 2012, BMC Research Notes.
[41] N. Mailand,et al. The ubiquitin‐ and SUMO‐dependent signaling response to DNA double‐strand breaks , 2011, FEBS letters.
[42] E. Yeh,et al. SUMOylation and de‐SUMOylation in response to DNA damage , 2011, FEBS letters.
[43] Shiaw-Yih Lin,et al. DNA damage and breast cancer. , 2011, World journal of clinical oncology.
[44] Nicolai J. Birkbak,et al. Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer , 2011, Cancer Epidemiology, Biomarkers & Prevention.
[45] X. Chen,et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. , 2011, The Journal of clinical investigation.
[46] Zoltan Szallasi,et al. Paradoxical relationship between chromosomal instability and survival outcome in cancer. , 2011, Cancer research.
[47] Laurent Sansregret,et al. Gene signatures of genomic instability as prognostic tools for breast cancer. , 2011, Future oncology.
[48] E. Wiechec. Implications of genomic instability in the diagnosis and treatment of breast cancer , 2011, Expert review of molecular diagnostics.
[49] Nicolai J. Birkbak,et al. Chromosomal instability confers intrinsic multidrug resistance. , 2011, Cancer research.
[50] Lincoln Stein,et al. Reactome: a database of reactions, pathways and biological processes , 2010, Nucleic Acids Res..
[51] S. Sleijfer,et al. Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes , 2011, Breast Cancer Research and Treatment.
[52] J. Benítez,et al. BRCA2 Acts as RAD51 Loader to Facilitate Telomere Replication and Capping , 2010, Nature Structural &Molecular Biology.
[53] David Haussler,et al. Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM , 2010, Bioinform..
[54] D. Compton,et al. Mechanisms of Chromosomal Instability , 2010, Current Biology.
[55] T. Halazonetis,et al. Genomic instability — an evolving hallmark of cancer , 2010, Nature Reviews Molecular Cell Biology.
[56] J. Lupski,et al. Mechanisms of change in gene copy number , 2009, Nature Reviews Genetics.
[57] Thomas J. Hardcastle,et al. Chromosomal instability determines taxane response , 2009, Proceedings of the National Academy of Sciences.
[58] S. Gasser,et al. Crosstalk between histone modifications during the DNA damage response. , 2009, Trends in cell biology.
[59] Sampsa Hautaniemi,et al. The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome , 2009, International journal of cancer.
[60] A. Nobel,et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[61] J. Holt,et al. Rad51 overexpression rescues radiation resistance in BRCA2‐defective cancer cells , 2009, Molecular carcinogenesis.
[62] A. Kauffmann,et al. Overexpression of DNA repair genes is associated with metastasis: a new hypothesis. , 2008, Mutation research.
[63] B. Orelli,et al. RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. , 2007, Cancer research.
[64] Z. Szallasi,et al. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers , 2006, Nature Genetics.
[65] A. Nobel,et al. The molecular portraits of breast tumors are conserved across microarray platforms , 2006, BMC Genomics.
[66] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[67] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[68] A. Ashworth,et al. Hallmarks of 'BRCAness' in sporadic cancers , 2004, Nature Reviews Cancer.
[69] Jeremy M. Stark,et al. Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability , 2004, Oncogene.
[70] R. Tibshirani,et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[71] D. Schild,et al. Mutants of the Five Rad51 Paralogs Recombinational Repair in Knockout Chromosome Instability and Defective , 2022 .
[72] P. Glazer,et al. Genomic instability in cancer. , 2001, Novartis Foundation symposium.
[73] Christian A. Rees,et al. Molecular portraits of human breast tumours , 2000, Nature.
[74] Hiroyuki Ogata,et al. KEGG: Kyoto Encyclopedia of Genes and Genomes , 1999, Nucleic Acids Res..