Serum Metabolomics of Retinoblastoma: Assessing the Differential Serum Metabolic Signatures of Unilateral and Bilateral Patients

[1]  Fan Yang,et al.  Cancer metabolites: promising biomarkers for cancer liquid biopsy , 2023, Biomarker Research.

[2]  Chang Sik Cho,et al.  Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice , 2023, Oncology reports.

[3]  Z. Nwosu,et al.  Uridine-derived ribose fuels glucose-restricted pancreatic cancer , 2023, Nature.

[4]  Shi Qiu,et al.  Small molecule metabolites: discovery of biomarkers and therapeutic targets , 2023, Signal Transduction and Targeted Therapy.

[5]  A. Valente,et al.  NMR-Based Metabolomics Demonstrates a Metabolic Change during Early Developmental Stages from Healthy Infants to Young Children , 2023, Metabolites.

[6]  Puneet,et al.  Association of altered metabolic profiles and long non-coding RNAs expression with disease severity in breast cancer patients: analysis by 1H NMR spectroscopy and RT-q-PCR , 2023, Metabolomics.

[7]  Jide Tian,et al.  The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19 , 2023, Biomedicines.

[8]  R. Shetty,et al.  Lack of Retinoblastoma Protein Shifts Tumor Metabolism from Glycolysis to OXPHOS and Allows the Use of Alternate Fuels , 2022, Cells.

[9]  S. Tripathi,et al.  Dissecting the molecular mechanisms of producing biofuel and value-added products by cadmium tolerant microalgae as sustainable biorefinery approach , 2022, Chemical Engineering Journal.

[10]  Meenakshi Sharma,et al.  Overexpression of bacteriophage T4 and T7 endolysins differentially regulate the metabolic fingerprint of host Escherichia coli. , 2022, International journal of biological macromolecules.

[11]  Zhibin Wang,et al.  Lactate metabolism in human health and disease , 2022, Signal Transduction and Targeted Therapy.

[12]  B. Sitter,et al.  Elevated Serum Lactate in Glioma Patients: Associated Factors , 2022, Frontiers in Oncology.

[13]  R. Shetty,et al.  Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors , 2022, Cells.

[14]  R. Chammas,et al.  Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells , 2022, Frontiers in Immunology.

[15]  Xiao-Fan Wang,et al.  Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression , 2022, Nature Cell Biology.

[16]  Dinesh Kumar,et al.  Serum Metabolic Disturbances in Lung Cancer Investigated through an Elaborative NMR-Based Serum Metabolomics Approach , 2022, ACS omega.

[17]  Y. Bao,et al.  Vitamin C Intake and Cancers: An Umbrella Review , 2022, Frontiers in Nutrition.

[18]  Xianqun Fan,et al.  Monitoring Retinoblastoma by Machine Learning of Aqueous Humor Metabolic Fingerprinting. , 2021, Small methods.

[19]  Liwen Zhang,et al.  The two sides of creatine in cancer. , 2021, Trends in cell biology.

[20]  D. Dunger,et al.  Metabolomics in early life and the association with body composition at age 2 years , 2021, Pediatric obesity.

[21]  J. Xia,et al.  MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights , 2021, Nucleic Acids Res..

[22]  M. V. Vander Heiden,et al.  Metabolomics in cancer research and emerging applications in clinical oncology , 2021, CA: a cancer journal for clinicians.

[23]  B. Firestein,et al.  Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation , 2021, Cells.

[24]  O. Ijare,et al.  The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling , 2021, Cancers.

[25]  F. N. Leeuwen,et al.  Amino Acid Depletion Therapies: Starving Cancer Cells to Death , 2021, Trends in Endocrinology & Metabolism.

[26]  Liyan Liu,et al.  Serum metabolite signatures of epithelial ovarian cancer based on targeted metabolomics. , 2021, Clinica chimica acta; international journal of clinical chemistry.

[27]  Min Su,et al.  The cancer metabolic reprogramming and immune response , 2021, Molecular cancer.

[28]  J. Jeon,et al.  Untargeted Metabolomics and Polyamine Profiling in Serum before and after Surgery in Colorectal Cancer Patients , 2020, Metabolites.

[29]  J. Decock,et al.  Lactate Metabolism and Immune Modulation in Breast Cancer: A Focused Review on Triple Negative Breast Tumors , 2020, Frontiers in Oncology.

[30]  T. Spector,et al.  A reference map of potential determinants for the human serum metabolome , 2020, Nature.

[31]  R. Powers,et al.  Quantitative NMR-Based Biomedical Metabolomics: Current Status and Applications , 2020, Molecules.

[32]  H. Biebermann,et al.  Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells , 2020, Laboratory Investigation.

[33]  Hui Peng,et al.  MULTIFACETED ROLE OF BRANCHED-CHAIN AMINO ACID METABOLISM IN CANCER , 2020, Oncogene.

[34]  N. Laforgia,et al.  Metabolomics Applications in Children: A Right Way to Go , 2020, Metabolites.

[35]  Hongming Miao,et al.  Metabolism in tumor microenvironment: Implications for cancer immunotherapy , 2020, MedComm.

[36]  G. Minchiotti,et al.  Proline Metabolism in Tumor Growth and Metastatic Progression , 2020, Frontiers in Oncology.

[37]  B. Faubert,et al.  Metabolic reprogramming and cancer progression , 2020, Science.

[38]  P. Kaiser.  Methionine Dependence of Cancer , 2020, Biomolecules.

[39]  Jayoung Kim,et al.  Identification of Metabolic Alterations in Breast Cancer Using Mass Spectrometry-Based Metabolomic Analysis , 2020, Metabolites.

[40]  I. Sagap,et al.  Global metabolomics profiling of colorectal cancer in Malaysian patients , 2020, BioImpacts : BI.

[41]  S. Sivanand,et al.  Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer. , 2020, Cancer cell.

[42]  D. Tennant,et al.  New aspects of amino acid metabolism in cancer , 2019, British Journal of Cancer.

[43]  David S. Wishart,et al.  Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis , 2019, Current protocols in bioinformatics.

[44]  J. Manzo-Merino,et al.  Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches , 2019, Front. Oncol..

[45]  B. V. Van Tine,et al.  Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers , 2019, Cancer drug resistance.

[46]  A. León-Del-Río.  Biotin in metabolism, gene expression, and human disease , 2019, Journal of inherited metabolic disease.

[47]  W. Barczak,et al.  Vitamin C as a Modulator of the Response to Cancer Therapy , 2019, Molecules.

[48]  Dinesh Kumar,et al.  NMR Based Metabolomics: An Exquisite and Facile Method for Evaluating Therapeutic Efficacy and Screening Drug Toxicity. , 2018, Current Topics in Medicinal Chemistry.

[49]  Karthik Raman,et al.  Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma , 2018, FEBS letters.

[50]  J. Xiong.  Fatty Acid Oxidation in Cell Fate Determination. , 2018, Trends in biochemical sciences.

[51]  B. Kreikemeyer,et al.  Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies , 2018, Cellular Physiology and Biochemistry.

[52]  J. L. Izquierdo-García,et al.  Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner , 2018, Cancer & metabolism.

[53]  V. Umashankar,et al.  Insights on ornithine decarboxylase silencing as a potential strategy for targeting retinoblastoma. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[54]  Martin Wilson,et al.  Metabolic profiling of the three neural derived embryonal pediatric tumors retinoblastoma, neuroblastoma and medulloblastoma, identifies distinct metabolic profiles , 2018, Oncotarget.

[55]  F. Hallböök,et al.  Heterogeneity in retinoblastoma: a tale of molecules and models , 2017, Clinical and Translational Medicine.

[56]  M. Touvier,et al.  NMR metabolomic signatures reveal predictive plasma metabolites associated with long-term risk of developing breast cancer. , 2017, International journal of epidemiology.

[57]  S. Kitajima,et al.  Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation , 2017, Cancer science.

[58]  C. Livi,et al.  Abstract 2515: Understanding metabolic dysfunction in retinoblastoma development , 2017 .

[59]  J. Vadgama,et al.  Lactate, a Neglected Factor for Diabetes and Cancer Interaction , 2016, Mediators of inflammation.

[60]  D. Fukumura,et al.  Arginine dependence of tumor cells: targeting a chink in cancer’s armor , 2016, Oncogene.

[61]  F. Mussai,et al.  Molecular basis and current strategies of therapeutic arginine depletion for cancer , 2016, International journal of cancer.

[62]  N. Dyson.  RB1: a prototype tumor suppressor and an enigma , 2016, Genes & development.

[63]  S. Liao,et al.  Metabolomics Reveals Dynamic Metabolic Changes Associated with Age in Early Childhood , 2016, PloS one.

[64]  Martin Wilson,et al.  Metabolite profiling in retinoblastoma identifies novel clinicopathological subgroups , 2015, British Journal of Cancer.

[65]  W. D. Cress,et al.  THE RETINOBLASTOMA PROTEIN: A MASTER TUMOR SUPPRESSOR ACTS AS A LINK BETWEEN CELL CYCLE AND CELL ADHESION. , 2014, Cell health and cytoskeleton.

[66]  R. Sinha,et al.  Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice , 2014, The Prostate.

[67]  M. Tempero,et al.  HR‐MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer , 2014, NMR in biomedicine.

[68]  S. Taylor-Robinson,et al.  Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans , 2014, Hepatology.

[69]  G. Hwang,et al.  Noninvasive Diagnosis and Evaluation of Curative Surgery for Gastric Cancer by Using NMR-based Metabolomic Profiling , 2014, Annals of Surgical Oncology.

[70]  I. Amelio,et al.  Serine and glycine metabolism in cancer☆ , 2014, Trends in biochemical sciences.

[71]  L. Satyanarayana,et al.  Childhood cancer incidence in India: A review of population-based cancer registries , 2014, Indian Pediatrics.

[72]  G. Cevenini,et al.  High Doses of Ascorbate Kill Y79 Retinoblastoma Cells In vitro , 2013 .

[73]  S. Moco,et al.  Metabolomics perspectives in pediatric research , 2013, Pediatric Research.

[74]  Juan Mendizabal-Zubiaga,et al.  GABA release by hippocampal astrocytes , 2012, Front. Comput. Neurosci..

[75]  E. Fukusaki,et al.  Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. , 2012, Biomedical chromatography : BMC.

[76]  F. Sotgia,et al.  Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment. , 2011, The international journal of biochemistry & cell biology.

[77]  Adam Ertel,et al.  Evidence for a stromal-epithelial “lactate shuttle” in human tumors , 2011, Cell cycle.

[78]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[79]  P. Mcgeer,et al.  Astrocytes are GABAergic cells that modulate microglial activity , 2011, Glia.

[80]  A. Tsirigos,et al.  Ketones and lactate “fuel” tumor growth and metastasis , 2010, Cell cycle.

[81]  B. Delage,et al.  Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer , 2010, International journal of cancer.

[82]  David S. Wishart,et al.  MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data , 2010, Nucleic Acids Res..

[83]  A. Vingrys,et al.  Glutamate metabolic pathways and retinal function , 2009, Journal of neurochemistry.

[84]  O. Feron,et al.  Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[85]  A. Bordey,et al.  GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches. , 2009, Physiology.

[86]  David S. Wishart,et al.  MetaboAnalyst: a web server for metabolomic data analysis and interpretation , 2009, Nucleic Acids Res..

[87]  Martin Wilson,et al.  High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours , 2009, Molecular Cancer.

[88]  J. Sage,et al.  Cellular mechanisms of tumour suppression by the retinoblastoma gene , 2008, Nature Reviews Cancer.

[89]  K. Knudsen,et al.  Tailoring to RB: tumour suppressor status and therapeutic response , 2008, Nature Reviews Cancer.

[90]  David S. Wishart,et al.  Quantitative metabolomics using NMR , 2008 .

[91]  J. H. Kim,et al.  Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma. , 2007, Oncology reports.

[92]  M. C. Angulo,et al.  Target cell-specific modulation of neuronal activity by astrocytes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[93]  A. Smilde,et al.  Centering, scaling, and transformations: improving the biological information content of metabolomics data , 2006, BMC Genomics.

[94]  J. Lindon,et al.  Scaling and normalization effects in NMR spectroscopic metabonomic data sets. , 2006, Analytical chemistry.

[95]  M. Kalloniatis,et al.  Creatine transporter localization in developing and adult retina: importance of creatine to retinal function. , 2005, American journal of physiology. Cell physiology.

[96]  H. Lim,et al.  Production of GABA by cultured hippocampal glial cells , 2004, Neurochemistry International.

[97]  D. Wheatley,et al.  Arginine deiminase: a potential inhibitor of angiogenesis and tumour growth , 2003, British Journal of Cancer.

[98]  R. Schipper,et al.  Distribution Patterns of Ornithine Decarboxylase in Cells and Tissues: Facts, Problems, and Postulates , 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[99]  Dragan Maric,et al.  Persistent Activation of GABAAReceptor/Cl− Channels by Astrocyte-Derived GABA in Cultured Embryonic Rat Hippocampal Neurons , 2000 .

[100]  B. S. Winkler.  Glycolytic and oxidative metabolism in relation to retinal function , 1981, The Journal of general physiology.

[101]  A. Knudson.  Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[102]  OUP accepted manuscript , 2021, Nucleic Acids Research.

[103]  António S. Barros,et al.  NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma. , 2015, Carcinogenesis.

[104]  Wei Liu,et al.  Proline metabolism and cancer. , 2012, Frontiers in bioscience.

[105]  J. Steyaert,et al.  PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: a mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment. , 2008, International journal of oncology.