Topical antiinflammatory dehydroabietylamine derivatives. IV

Abstract Four derivatives of dehydroabietylamine were synthesized as potential phospholipase-A 2 (PLA 2 ) inhibitors and found to be active as topical antiinflammatory as demonstrated in the tetradecanoyl phorbol acetate induced ear edema assay (TPA Ear). An attempt has been made to explain the antiinflammatory activity of these compounds based on their biochemical profiles.

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