Circulating thrombospondin-2 in patients with moderate-to-severe chronic heart failure due to coronary artery disease

Abstract Chronic heart failure (CHF) remains a leading cause of morbidity and mortality. In the current study, we aimed to evaluate the predictive value of circulating thrombospondin-2 (TSP-2) for cumulative survival in patients with ischemic CHF due to coronary artery disease (CAD). The results showed that during a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repeatedly. The median circulating levels of TSP-2 in patients who survived and those who died were 0.63 ng/mL (95%CI = 0.55-0.64 ng/mL) and 1.03 ng/mL (95% CI = 0.97-1.07 ng/mL) (P<0.001). Circulating TSP-2 independently predicted all-cause mortality (OR = 1.27; 95%CI = 1.08–1.59; P = 0.002), CHF-related death (OR = 1.16; 95%CI = 1.02–1.50; P<0.001), and also CHF-related rehospitalization (OR = 1.12; 95%CI = 1.07–1.25; P<0.001). In conclusion, among CAD patients with symptomatic CHF, increased circulating TSP-2 is correlated with increased 3-year CHF-related death, all-cause mortality, and risk for recurrent hospitalization.

[1]  S. Umemura,et al.  Peripheral Endothelial Function and Cardiovascular Events in High‐Risk Patients , 2013, Journal of the American Heart Association.

[2]  H. Ogawa,et al.  Circulating Thrombospondin-2 Levels Correlate with Disease Severity and Predict Mortality in Patients with Diastolic Heart Failure , 2013 .

[3]  H. Ogawa,et al.  Thrombospondin-2 is a Useful Biomarker in Patients with Reduced Left Ventricular Ejection Fraction , 2013 .

[4]  J. Golledge,et al.  The role of thrombospondin-1 in cardiovascular health and pathology. , 2013, International journal of cardiology.

[5]  A. Lichtman.  The heart of the matter: protection of the myocardium from T cells. , 2013, Journal of autoimmunity.

[6]  L. A. Bonet,et al.  ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 , 2012, Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.

[7]  B. Aronow,et al.  A Thrombospondin-Dependent Pathway for a Protective ER Stress Response , 2012, Cell.

[8]  P. Carmeliet,et al.  Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. , 2011, Journal of molecular and cellular cardiology.

[9]  P. Villa,et al.  Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients. , 2008, International journal of cardiology.

[10]  W. Sessa,et al.  Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. , 2008, The American journal of pathology.

[11]  A. Foussat,et al.  Interactions between CD47 and Thrombospondin Reduce Inflammation1 , 2007, The Journal of Immunology.

[12]  R. Rebres,et al.  Novel CD47‐dependent intercellular adhesion modulates cell migration , 2005, Journal of cellular physiology.

[13]  M. Entman,et al.  Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts , 2005, Circulation.

[14]  R. Duisters,et al.  Thrombospondin-2 Is Essential for Myocardial Matrix Integrity: Increased Expression Identifies Failure-Prone Cardiac Hypertrophy , 2004, Circulation research.

[15]  C Veyrat,et al.  Tissue Doppler, strain, and strain rate echocardiography for the assessment of left and right systolic ventricular function , 2003, Heart.

[16]  P. Bornstein,et al.  Thrombospondin 2, a matricellular protein with diverse functions. , 2000, Matrix biology : journal of the International Society for Matrix Biology.

[17]  J. Lawler.  The functions of thrombospondin-1 and-2. , 2000, Current opinion in cell biology.

[18]  N. Reichek,et al.  Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. , 1989, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[19]  A. Foussat,et al.  Interactions between CD47 and Thrombospondin Reduce Inflammation , 2007 .

[20]  P. Bornstein,et al.  Thrombospondin 2 levels are increased in aged mice: consequences for cutaneous wound healing and angiogenesis. , 2004, Matrix biology : journal of the International Society for Matrix Biology.