Inlets and sampling

Abstract When transferring an analytical method from one-dimensional to multidimensional gas chromatography (MDGC), certain parameters require special attention. Here, the sample preparation (SP) and sample introduction are usually the least considered. However, even the most advanced MDGC approach is incapable of compensating for poor SP and injection. Therefore, a reevaluation of these analytical steps is certainly useful when methods are transferred to MDGC. This chapter provides a brief overview of the basic principles and applications of SP and introduction techniques commonly applied in MDGC. In addition, the effects of these techniques on the chromatographic process and the analytical results are discussed. The considerations presented here are intended to provide helpful information for beginners in MDGC.