Efficacy of oral corticosteroids in the treatment of acute wheezing episodes in asthmatic preschoolers: Systematic review with meta‐analysis

Systemic corticosteroids (SCS) are used for treat preschoolers with acute asthma or wheezing exacerbations, with conflicting results.

[1]  P. Gosset,et al.  Airway Remodeling in Preschool Children with Severe Recurrent Wheeze. , 2015, American journal of respiratory and critical care medicine.

[2]  W. Teague Prednisone for acute virus-associated wheeze in children: Panacea or one more brick in the wall? , 2015, The Journal of allergy and clinical immunology.

[3]  P. Shekelle,et al.  Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation , 2015, BMJ : British Medical Journal.

[4]  T. To,et al.  Trends in the age of diagnosis of childhood asthma. , 2014, The Journal of allergy and clinical immunology.

[5]  A. D. Collins,et al.  An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children , 2014, Therapeutic advances in respiratory disease.

[6]  L. Bacharier,et al.  The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing. , 2014, The Journal of allergy and clinical immunology.

[7]  C. Lemière,et al.  Determinants Of Oral corticosteroid Responsiveness in Wheezing Asthmatic Youth (DOORWAY): protocol for a prospective multicentre cohort study of children with acute moderate-to-severe asthma exacerbations , 2014, BMJ Open.

[8]  Tonya S. King,et al.  Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? , 2013, The Journal of allergy and clinical immunology.

[9]  G. Burke,et al.  Corticosteroid Timing and Length of Stay for Children with Asthma in the Emergency Department , 2012, The Journal of asthma : official journal of the Association for the Care of Asthma.

[10]  N. Barrowman,et al.  Triage Nurse Initiation of Corticosteroids in Pediatric Asthma Is Associated With Improved Emergency Department Efficiency , 2012, Pediatrics.

[11]  G. Joyce,et al.  Out-of-pocket medication costs and use of medications and health care services among children with asthma. , 2012, JAMA.

[12]  J. Sterne,et al.  The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials , 2011, BMJ : British Medical Journal.

[13]  R. Goldman,et al.  Single-dose dexamethasone for mild-to-moderate asthma exacerbations: effective, easy, and acceptable. , 2011, Canadian family physician Medecin de famille canadien.

[14]  P. Camargos,et al.  Oral and inhaled corticoid treatment for wheezing in the first year of life. , 2011, Jornal de pediatria.

[15]  P. Lambert,et al.  Oral prednisolone for preschool children with acute virus-induced wheezing. , 2009, The New England journal of medicine.

[16]  O. Simell,et al.  Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study , 2009, Respiratory research.

[17]  S. Minatoguchi,et al.  Effect of Intermittent Systemic Corticosteroid on Bone Metabolism in Bronchial Asthma Patients , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[18]  B. Volovitz Inhaled corticosteroids as rescue medication in asthma exacerbations in children , 2008, Expert review of clinical immunology.

[19]  D. Kohen,et al.  Changes in the prevalence of asthma among Canadian children. , 2008, Health reports.

[20]  Douglas G. Altman,et al.  Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta‐Analysis , 2008 .

[21]  M. Mäkelä,et al.  Atopic characteristics of wheezing children and responses to prednisolone , 2007, Pediatric pulmonology.

[22]  M. Mäkelä,et al.  Efficacy of prednisolone in children hospitalized for recurrent wheezing , 2007, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[23]  M. Mäkelä,et al.  Evaluation of the Efficacy of Prednisolone in Early Wheezing Induced by Rhinovirus or Respiratory Syncytial Virus , 2006, The Pediatric infectious disease journal.

[24]  T. To,et al.  The Ontario Asthma Regional Variation Study: emergency department visit rates and the relation to hospitalization rates. , 2006, Chest.

[25]  Ich Harmonised,et al.  INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE , 2006 .

[26]  Stefano Guerra,et al.  Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. , 2005, American journal of respiratory and critical care medicine.

[27]  A. Milner,et al.  Treatment of recurrent acute wheezing episodes in infancy with oral salbutamol and prednisolone , 1996, European Journal of Pediatrics.

[28]  Feng Li,et al.  An Introduction to Metaanalysis , 2005 .

[29]  P. Lambert,et al.  Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1–5 years: randomised controlled trial , 2003, The Lancet.

[30]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[31]  F. Glorieux,et al.  Safety profile of frequent short courses of oral glucocorticoids in acute pediatric asthma: impact on bone metabolism, bone density, and adrenal function. , 2003, Pediatrics.

[32]  U. Frey,et al.  Age-related differences in perceived asthma control in childhood: guidelines and reality , 2002, European Respiratory Journal.

[33]  Third Expert Panel on theDiagnosis,et al.  Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma , 1997 .

[34]  C. Grant,et al.  Independent parental administration of prednisone in acute asthma: a double-blind, placebo-controlled, crossover study. , 1995, Pediatrics.

[35]  S. Fuchs,et al.  Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. , 1993, Pediatrics.

[36]  Alfred O. Berg,et al.  Clinical Guidelines And Primary Care Guidelines For The Diagnosis And Management Of Asthma , 2012 .

[37]  J. G. Gleeson,et al.  Placebo Controlled Trial of Systemic Corticosteroids in Acute Childhood Asthma , 1990, Acta paediatrica Scandinavica.

[38]  A. Tal,et al.  Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial. , 1990, Pediatrics.

[39]  W. Lenney,et al.  EFFECT OF A SINGLE ORAL DOSE OF PREDNISOLONE IN ACUTE CHILDHOOD ASTHMA , 1987, The Lancet.

[40]  A. Milner,et al.  Oral corticosteroids for wheezing attacks under 18 months. , 1986, Archives of disease in childhood.