Guidelines for Improving Entry Into and Retention in Care and Antiretroviral Adherence for Persons With HIV: Evidence-Based Recommendations From an International Association of Physicians in AIDS Care Panel

DESCRIPTION After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). Adherence to ART is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of drug resistance. The International Association of Physicians in AIDS Care convened a panel to develop evidence-based recommendations to optimize entry into and retention in care and ART adherence for people with HIV. METHODS A systematic literature search was conducted to produce an evidence base restricted to randomized, controlled trials and observational studies with comparators that had at least 1 measured biological or behavioral end point. A total of 325 studies met the criteria. Two reviewers independently extracted and coded data from each study using a standardized data extraction form. Panel members drafted recommendations based on the body of evidence for each method or intervention and then graded the overall quality of the body of evidence and the strength for each recommendation. RECOMMENDATIONS Recommendations are provided for monitoring entry into and retention in care, interventions to improve entry and retention, and monitoring of and interventions to improve ART adherence. Recommendations cover ART strategies, adherence tools, education and counseling, and health system and service delivery interventions. In addition, they cover specific issues pertaining to pregnant women, incarcerated individuals, homeless and marginally housed individuals, and children and adolescents, as well as substance use and mental health disorders. Recommendations for future research in all areas are also provided.

[1]  C. Kemper,et al.  Effect of a Brief Antiretroviral Adherence Intervention Delivered by HIV Care Providers , 2005, Journal of acquired immune deficiency syndromes.

[2]  Ahnalee M. Brincks,et al.  A randomized controlled trial of Structural Ecosystems Therapy for HIV medication adherence and substance abuse relapse prevention. , 2010, Drug and alcohol dependence.

[3]  N. Petry,et al.  Group-based randomized trial of contingencies for health and abstinence in HIV patients. , 2010, Journal of consulting and clinical psychology.

[4]  David Huh,et al.  Peer Support and Pager Messaging to Promote Antiretroviral Modifying Therapy in Seattle: A Randomized Controlled Trial , 2009, Journal of acquired immune deficiency syndromes.

[5]  Charles Abraham,et al.  Standard care impact on effects of highly active antiretroviral therapy adherence interventions: A meta-analysis of randomized controlled trials. , 2010, Archives of internal medicine.

[6]  D. Bangsberg,et al.  Multiple Validated Measures of Adherence Indicate High Levels of Adherence to Generic HIV Antiretroviral Therapy in a Resource-Limited Setting , 2004, Journal of acquired immune deficiency syndromes.

[7]  Gary Marks,et al.  Efficacy of Interventions in Improving Highly Active Antiretroviral Therapy Adherence and HIV-1 RNA Viral Load: A Meta-Analytic Review of Randomized Controlled Trials , 2006, Journal of acquired immune deficiency syndromes.

[8]  David V Glidden,et al.  Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. , 2010, The New England journal of medicine.

[9]  Blair T. Johnson,et al.  Efficacy of Antiretroviral Therapy Adherence Interventions: A Research Synthesis of Trials, 1996 to 2004 , 2006, Journal of acquired immune deficiency syndromes.

[10]  K. Squires,et al.  A randomized trial of directly administered antiretroviral therapy and adherence case management intervention. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  Diane P. Martin,et al.  Randomized Control Trial of Peer-Delivered, Modified Directly Observed Therapy for HAART in Mozambique , 2007, Journal of acquired immune deficiency syndromes.

[12]  G. Kok,et al.  Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among HIV-infected patients in the Netherlands: a pilot study. , 2005, AIDS patient care and STDs.

[13]  M. Brady,et al.  Directly observed highly active antiretroviral therapy for HIV-infected children in Cambodia. , 2007, American Journal of Public Health.

[14]  S. Boswell,et al.  Use of an on-line pager system to increase adherence to antiretroviral medications , 2003, AIDS care.

[15]  Richard D Moore,et al.  Clinic-Based Treatment of Opioid-Dependent HIV-Infected Patients Versus Referral to an Opioid Treatment Program , 2010, Annals of Internal Medicine.

[16]  D. Rao,et al.  Stigma and social barriers to medication adherence with urban youth living with HIV , 2007, AIDS care.

[17]  Michael Rayment,et al.  Prevention of HIV-1 infection with early antiretroviral therapy , 2012, Journal of Family Planning and Reproductive Health Care.

[18]  R. Chaisson,et al.  Highly Active Antiretroviral Therapy in a Large Urban Clinic: Risk Factors for Virologic Failure and Adverse Drug Reactions , 1999, Annals of Internal Medicine.

[19]  J. Fleishman,et al.  Disparities in Antiretroviral Treatment: A Comparison of Behaviorally HIV-Infected Youth and Adults in the HIV Research Network , 2011, Journal of acquired immune deficiency syndromes.

[20]  A. Webel Testing a peer-based symptom management intervention for women living with HIV/AIDS , 2010, AIDS care.

[21]  J. Rich,et al.  Successful linkage of medical care and community services for HIV-positive offenders being released from prison , 2001, Journal of Urban Health.

[22]  B G Gazzard,et al.  Switching from twice‐daily abacavir and lamivudine to the once‐daily fixed‐dose combination tablet of abacavir and lamivudine improves patient adherence and satisfaction with therapy , 2008, HIV medicine.

[23]  D. Ellis,et al.  Use of multisystemic therapy to improve antiretroviral adherence and health outcomes in HIV-infected pediatric patients: evaluation of a pilot program. , 2006, AIDS patient care and STDs.

[24]  C. Cunningham,et al.  Strategies to Improve Access to and Utilization of Health Care Services and Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users , 2011, Substance use & misuse.

[25]  Mark J van der Laan,et al.  Pillbox organizers are associated with improved adherence to HIV antiretroviral therapy and viral suppression: a marginal structural model analysis. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[26]  J. Cramer,et al.  Improved adherence with contingency management. , 2007, AIDS patient care and STDs.

[27]  Heather Ribaudo,et al.  A randomized study of serial telephone call support to increase adherence and thereby improve virologic outcome in persons initiating antiretroviral therapy. , 2005, The Journal of infectious diseases.

[28]  N. Schneiderman,et al.  Randomized Clinical Trial of Cognitive Behavioral Stress Management on Human Immunodeficiency Virus Viral Load in Gay Men Treated With Highly Active Antiretroviral Therapy , 2006, Psychosomatic medicine.

[29]  William Coady,et al.  Provider-Focused Intervention Increases Adherence-Related Dialogue but Does Not Improve Antiretroviral Therapy Adherence in Persons With HIV , 2010, Journal of acquired immune deficiency syndromes.

[30]  R. Hogg,et al.  Food Insecurity is Associated with Incomplete HIV RNA Suppression Among Homeless and Marginally Housed HIV-infected Individuals in San Francisco , 2008, Journal of General Internal Medicine.

[31]  D. Bangsberg,et al.  100% Adherence Study: Educational Workshops vs. Video Sessions to Improve Adherence Among ART-Naïve Patients in Salvador, Brazil , 2008, AIDS and Behavior.

[32]  Sonya S. Shin,et al.  Community-based DOT-HAART Accompaniment in an Urban Resource-Poor Setting , 2010, AIDS and Behavior.

[33]  Thomas P Giordano,et al.  Accessing antiretroviral therapy following release from prison. , 2009, JAMA.

[34]  C. Flexner,et al.  Comparison of once-daily versus twice-daily combination antiretroviral therapy in treatment-naive patients: results of AIDS clinical trials group (ACTG) A5073, a 48-week randomized controlled trial. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[35]  C. Rayner,et al.  Multidisciplinary HIV adherence intervention: a randomized study. , 2004, AIDS patient care and STDs.

[36]  J. Sankalé,et al.  Direct observation therapy-highly active antiretroviral therapy in a resource-limited setting: the use of community treatment support can be effective , 2007, International journal of STD & AIDS.

[37]  R. Haubrich,et al.  Four Measures of Antiretroviral Medication Adherence and Virologic Response in AIDS Clinical Trials Group Study 359 , 2005, Journal of acquired immune deficiency syndromes.

[38]  Cristian Pop-Eleches,et al.  Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders , 2011, AIDS.

[39]  M. Johnson,et al.  A lopinavir/ritonavir-based once-daily regimen results in better compliance and is non-inferior to a twice-daily regimen through 96 weeks. , 2007, AIDS research and human retroviruses.

[40]  F. Altice,et al.  Effectiveness of antiretroviral therapy among HIV-infected prisoners: reincarceration and the lack of sustained benefit after release to the community. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[41]  A. DeMaria,et al.  Adherence to medication regimens among children with human immunodeficiency virus infection , 2000, The Pediatric infectious disease journal.

[42]  D. Harris,et al.  Improving health outcomes for youth living with the human immunodeficiency virus: a multisite randomized trial of a motivational intervention targeting multiple risk behaviors. , 2009, Archives of pediatrics & adolescent medicine.

[43]  Lynn Morris,et al.  Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women , 2010, Science.

[44]  D. Glikman,et al.  Hospital-Based Directly Observed Therapy for HIV-Infected Children and Adolescents to Assess Adherence to Antiretroviral Medications , 2007, Pediatrics.

[45]  F. Altice,et al.  Medication persistence in the treatment of HIV infection: a review of the literature and implications for future clinical care and research , 2011, AIDS.

[46]  R. Badaró,et al.  Lack of effect of motivation on the adherence of HIV-positive/AIDS patients to antiretroviral treatment. , 2005, The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.

[47]  E. Hockman,et al.  Retaining Women in HIV Medical Care , 2007, The Journal of the Association of Nurses in AIDS Care : JANAC.

[48]  Dean Wantland,et al.  Testing a Nurse-Tailored HIV Medication Adherence Intervention , 2006, Nursing research.

[49]  T. Quinn,et al.  Effect of Peer Health Workers on AIDS Care in Rakai, Uganda: A Cluster-Randomized Trial , 2010, PloS one.

[50]  Ross J. Harris,et al.  Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[51]  F. Mostashari,et al.  Acceptance and adherence with antiretroviral therapy among HIV-infected women in a correctional facility. , 1998, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

[52]  F. Altice,et al.  Adaptation of an evidence-based intervention targeting HIV-infected prisoners transitioning to the community: the process and outcome of formative research for the Positive Living Using Safety (PLUS) intervention. , 2009, AIDS patient care and STDs.

[53]  M. Marcos,et al.  Adherence to highly active antiretroviral therapy in HIV-infected inmates. , 2008, Current HIV Research.

[54]  R. Gross,et al.  Antiretroviral Failure Despite High Levels of Adherence: Discordant Adherence-Response Relationship in Botswana , 2008, Journal of acquired immune deficiency syndromes.

[55]  Christa R. Nevin,et al.  From access to engagement: measuring retention in outpatient HIV clinical care. , 2010, AIDS patient care and STDs.

[56]  Julio S. G. Montaner,et al.  Dose-response effect of incarceration events on nonadherence to HIV antiretroviral therapy among injection drug users. , 2011, The Journal of infectious diseases.

[57]  Michelle E. Kho,et al.  AGREE II: advancing guideline development, reporting and evaluation in health care , 2010, Canadian Medical Association Journal.

[58]  W. Peetermans,et al.  Diagnostic value of different adherence measures using electronic monitoring and virologic failure as reference standards. , 2008, AIDS patient care and STDs.

[59]  J. Hogan,et al.  A randomized clinical trial of community-based directly observed therapy as an adherence intervention for HAART among substance users , 2007, AIDS.

[60]  V. Calvez,et al.  Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy. Trilège (Agence Nationale de Recherches sur le SIDA 072) Study Team). , 2000, JAMA.

[61]  Scott R. Smith,et al.  A medication self-management program to improve adherence to HIV therapy regimens. , 2003, Patient education and counseling.

[62]  R. Gross,et al.  A time-to-prescription-refill measure of antiretroviral adherence predicted changes in viral load in HIV. , 2004, Journal of clinical epidemiology.

[63]  D. Heckathorn,et al.  Increasing drug users' adherence to HIV treatment: results of a peer-driven intervention feasibility study. , 2002, Social science & medicine.

[64]  Traci Mann,et al.  Effects of future writing and optimism on health behaviors in HIV-infected women , 2001, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[65]  J. Prada,et al.  Prospective, randomized, two-arm controlled study to evaluate two interventions to improve adherence to antiretroviral therapy in Spain. , 2010, Enfermedades infecciosas y microbiologia clinica.

[66]  G. Bárbaro Cardiovascular manifestations of HIV infection. , 2002, Circulation.

[67]  Edward P Acosta,et al.  Comparison of Two Strategies for Administering Nevirapine to Prevent Perinatal HIV Transmission in High-Prevalence, Resource-Poor Settings , 2003, Journal of acquired immune deficiency syndromes.

[68]  G. Marks,et al.  Brief Strengths-Based Case Management Promotes Entry Into HIV Medical Care: Results of the Antiretroviral Treatment Access Study-II , 2008, Journal of acquired immune deficiency syndromes.

[69]  U. Ehlert,et al.  Effects of cognitive behavioral stress management on HIV-1 RNA, CD4 cell counts and psychosocial parameters of HIV-infected persons , 2008, AIDS.

[70]  P. Shekelle,et al.  The Development of Clinical Practice Guidelines and Guidance Statements of the American College of Physicians: Summary of Methods , 2010, Annals of Internal Medicine.

[71]  P. Barton,et al.  Antidepressant Treatment Improves Adherence to Antiretroviral Therapy Among Depressed HIV-Infected Patients , 2005, Journal of acquired immune deficiency syndromes.

[72]  R. D. Bruce,et al.  Persistence of Virological Benefits Following Directly Administered Antiretroviral Therapy Among Drug Users: Results From a Randomized Controlled Trial , 2009, Journal of acquired immune deficiency syndromes.

[73]  C. Porter,et al.  A 2-Arm, Randomized, Controlled Trial of a Motivational Interviewing-Based Intervention to Improve Adherence to Antiretroviral Therapy (ART) Among Patients Failing or Initiating ART , 2006, Journal of acquired immune deficiency syndromes.

[74]  F. Altice,et al.  Improved HIV and Substance Abuse Treatment Outcomes for Released HIV-Infected Prisoners: The Impact of Buprenorphine Treatment , 2010, Journal of Urban Health.

[75]  G. Luftman,et al.  Antiretroviral adherence issues among HIV-positive adolescents and young adults. , 1999, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[76]  Christine Laine,et al.  Trustworthy Clinical Guidelines , 2011, Annals of Internal Medicine.

[77]  Evan Wood,et al.  Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study , 2010, The Lancet.

[78]  M. Suarez‐Almazor,et al.  Retention in care: a challenge to survival with HIV infection. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[79]  K. Hawkins,et al.  A randomized clinical trial of a manual-guided risk reduction intervention for HIV-positive injection drug users. , 2003, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[80]  Nadia L. Dowshen,et al.  Health Care Transition for Youth Living With HIV/AIDS , 2011, Pediatrics.

[81]  N. Schneiderman,et al.  Enhancing adherence to combination antiretroviral therapy in non-adherent HIV-positive men , 2000, AIDS care.

[82]  P. de Truchis,et al.  Family nutritional support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country. , 2010, Asia Pacific journal of clinical nutrition.

[83]  F. Hecht,et al.  Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population , 2000, AIDS.

[84]  E. Morse,et al.  Sustained Benefit From a Long-Term Antiretroviral Adherence Intervention: Results of a Large Randomized Clinical Trial , 2006, Journal of acquired immune deficiency syndromes.

[85]  K. Resnicow,et al.  Using motivational interviewing to promote adherence to antiretroviral medications: a pilot study. , 2003, The Journal of the Association of Nurses in AIDS Care : JANAC.

[86]  A. Carballo-Diéguez,et al.  Couple-focused support to improve HIV medication adherence: a randomized controlled trial , 2005, AIDS.

[87]  B. Zomer,et al.  Assessment of Adherence to HIV Protease Inhibitors: Comparison and Combination of Various Methods, Including MEMS (Electronic Monitoring), Patient and Nurse Report, and Therapeutic Drug Monitoring , 2002, Journal of acquired immune deficiency syndromes.

[88]  G. Guyatt,et al.  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations , 2008, BMJ : British Medical Journal.

[89]  B. Agins,et al.  Retaining HIV-infected patients in care: Where are we? Where do we go from here? , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[90]  D. Ward,et al.  Simplification of Antiretroviral Therapy to a Single-Tablet Regimen Consisting of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate Versus Unmodified Antiretroviral Therapy in Virologically Suppressed HIV-1-Infected Patients , 2009, Journal of acquired immune deficiency syndromes.

[91]  Tania B. Huedo-Medina,et al.  Adherence to Highly Active Antiretroviral Therapy (HAART): A Meta-Analysis , 2011, AIDS and Behavior.

[92]  R. Walensky,et al.  Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[93]  M. Lee,et al.  A programme of symptom management for improving quality of life and drug adherence in AIDS/HIV patients. , 2006, Journal of advanced nursing.

[94]  Judith Chwalow,et al.  Impact of a patient education program on adherence to HIV medication: a randomized clinical trial. , 2003, Journal of acquired immune deficiency syndromes.

[95]  David R. Holtgrave,et al.  Randomized Trial of the Effects of Housing Assistance on the Health and Risk Behaviors of Homeless and Unstably Housed People Living with HIV , 2010, AIDS and Behavior.

[96]  Sydney Rosen,et al.  Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review , 2007, PLoS medicine.

[97]  J. Tolson,et al.  Impact of an educational program on efficacy and adherence with a twice-daily lamivudine/zidovudine/abacavir regimen in underrepresented HIV-infected patients. , 2003, Journal of acquired immune deficiency syndromes.

[98]  Jerome H. Carter,et al.  Distribution of health care expenditures for HIV-infected patients. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[99]  I. Wilson,et al.  Using Electronic Drug Monitor Feedback to Improve Adherence to Antiretroviral Therapy Among HIV-Positive Patients in China , 2009, AIDS and Behavior.

[100]  B. Gazzard,et al.  Better maintained adherence on switching from twice‐daily to once‐daily therapy for HIV: a 24‐week randomized trial of treatment simplification using stavudine prolonged‐release capsules , 2005, HIV medicine.

[101]  Julio S. G. Montaner,et al.  A simple, dynamic measure of antiretroviral therapy adherence predicts failure to maintain HIV-1 suppression. , 2006, The Journal of infectious diseases.

[102]  M. Chesney,et al.  Differential adherence to combination antiretroviral therapy is associated with virological failure with resistance , 2008, AIDS.

[103]  A. Westfall,et al.  Missed visits and mortality among patients establishing initial outpatient HIV treatment. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[104]  R. Wood,et al.  Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial , 2010, The Lancet.

[105]  S. Rosen,et al.  Retention in HIV Care between Testing and Treatment in Sub-Saharan Africa: A Systematic Review , 2011, PLoS medicine.

[106]  P. Harrigan,et al.  Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. , 2005, The Journal of infectious diseases.

[107]  S. Rai,et al.  Efficacy of a Pill-Swallowing Training Intervention to Improve Antiretroviral Medication Adherence in Pediatric Patients With HIV/AIDS , 2007, Pediatrics.

[108]  B. Clotet,et al.  Clinical implications of fixed-dose coformulations of antiretrovirals on the outcome of HIV-1 therapy , 2011, AIDS.

[109]  D. Bangsberg,et al.  Not All Missed Doses Are the Same: Sustained NNRTI Treatment Interruptions Predict HIV Rebound at Low-to-Moderate Adherence Levels , 2008, PloS one.

[110]  J. Hogan,et al.  The Use of Community-Based Modified Directly Observed Therapy for the Treatment of HIV-Infected Persons , 2005, Journal of acquired immune deficiency syndromes.

[111]  O. Kirk,et al.  Class of antiretroviral drugs and the risk of myocardial infarction. , 2007, The New England journal of medicine.

[112]  T. Neilands,et al.  Improving Coping Skills for Self-management of Treatment Side Effects Can Reduce Antiretroviral Medication Nonadherence among People Living with HIV , 2010, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[113]  L. D. Saunders,et al.  Results of a community-based antiretroviral treatment program for HIV-1 infection in Western Uganda. , 2010, Current HIV research.

[114]  Susan Swindells,et al.  Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection , 2000, Annals of Internal Medicine.

[115]  Patrick A Ryscavage,et al.  Clinical Outcomes of Adolescents and Young Adults in Adult HIV Care , 2011, Journal of acquired immune deficiency syndromes.

[116]  R. Hays,et al.  Measuring Adherence to Antiretroviral Medications in Clinical Trials , 2000, HIV clinical trials.

[117]  K. Resnicow,et al.  Using motivational interviewing to promote adherence to antiretroviral medications: A randomized controlled study , 2008, AIDS care.

[118]  Robert L. Johnson,et al.  Transitioning youths into care: linking identified HIV-infected youth at outreach sites in the community to hospital-based clinics and or community-based health centers. , 2003, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[119]  G. Kok,et al.  Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: a randomized controlled trial. , 2010, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[120]  K. Pallangyo,et al.  Enhancing adherence to antiretroviral therapy at the HIV clinic in resource constrained countries; the Tanzanian experience , 2009, Tropical medicine & international health : TM & IH.

[121]  L. Kux OF HEALTH AND HUMAN SERVICES Food and Drug Administration , 2014 .

[122]  Lei Wang,et al.  Prevention of HIV-1 infection with early antiretroviral therapy. , 2011, The New England journal of medicine.

[123]  M. Petersen,et al.  A marginal structural model to estimate the causal effect of antidepressant medication treatment on viral suppression among homeless and marginally housed persons with HIV. , 2010, Archives of general psychiatry.

[124]  C. Latkin,et al.  Results From a Randomized Controlled Trial of a Peer-Mentoring Intervention to Reduce HIV Transmission and Increase Access to Care and Adherence to HIV Medications Among HIV-Seropositive Injection Drug Users , 2007, Journal of acquired immune deficiency syndromes.

[125]  Sylvie Naar-King,et al.  Psychosocial factors and medication adherence in HIV-positive youth. , 2006, AIDS patient care and STDs.

[126]  Sundhiya Mandalia,et al.  Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome , 2002, AIDS.

[127]  S. Kalra,et al.  Understanding diabetes in patients with HIV/AIDS , 2011, Diabetology & metabolic syndrome.

[128]  M. Heo,et al.  Directly observed antiretroviral therapy improves adherence and viral load in drug users attending methadone maintenance clinics: a randomized controlled trial. , 2011, Drug and alcohol dependence.

[129]  J. Farley,et al.  Assessment of adherence to antiviral therapy in HIV-infected children using the Medication Event Monitoring System, pharmacy refill, provider assessment, caregiver self-report, and appointment keeping. , 2003, Journal of acquired immune deficiency syndromes.

[130]  B. Chi,et al.  A Pilot Study of Food Supplementation to Improve Adherence to Antiretroviral Therapy Among Food-Insecure Adults in Lusaka, Zambia , 2008, Journal of acquired immune deficiency syndromes.

[131]  C. Rayner,et al.  Randomized trial of an adherence programme for clients with HIV , 2003, International journal of STD & AIDS.

[132]  J. Bradford,et al.  HIV System Navigation: an emerging model to improve HIV care access. , 2007, AIDS patient care and STDs.

[133]  C. Flexner,et al.  Modified directly observed antiretroviral therapy compared with self-administered therapy in treatment-naive HIV-1-infected patients: a randomized trial. , 2009, Archives of internal medicine.

[134]  Scott R. Smith,et al.  Using digital videos displayed on personal digital assistants (PDAs) to enhance patient education in clinical settings , 2007, Int. J. Medical Informatics.

[135]  J. Stringer,et al.  A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia , 2010, AIDS.

[136]  T. Gilmer,et al.  Evaluation of the First Year of a Pilot Program in Community Pharmacy: HIV/AIDS Medication Therapy Management for Medi-Cal Beneficiaries , 2009, Journal of managed care pharmacy : JMCP.

[137]  H. Günthard,et al.  Effect of Individual Cognitive Behaviour Intervention on Adherence to Antiretroviral Therapy: Prospective Randomized Trial , 2004, Antiviral therapy.

[138]  H. Palacio,et al.  Case management is associated with improved antiretroviral adherence and CD4+ cell counts in homeless and marginally housed individuals with HIV infection. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[139]  N. Schneiderman,et al.  Enhancing the health of women living with HIV: the SMART/EST Women’s Project , 2011, International journal of women's health.

[140]  R. Haubrich,et al.  Cognitive-behavioral intervention to enhance adherence to antiretroviral therapy: a randomized controlled trial (CCTG 578) , 2006, AIDS.

[141]  S. Zeichner,et al.  Patient, Caregiver and Regimen Characteristics Associated With Adherence to Highly Active Antiretroviral Therapy Among HIV-Infected Children and Adolescents , 2007, The Pediatric infectious disease journal.

[142]  M. Tyndall,et al.  Piloting a peer-driven intervention model to increase access and adherence to antiretroviral therapy and HIV care among street-entrenched HIV-positive women in Vancouver. , 2009, AIDS patient care and STDs.

[143]  R. Hogg,et al.  Methadone maintenance therapy promotes initiation of antiretroviral therapy among injection drug users. , 2010, Addiction.

[144]  B. Laurence,et al.  Efficacy of an Educational and Counseling Intervention on Adherence to Highly Active Antiretroviral Therapy: French Prospective Controlled Study , 2003 .

[145]  Becky White,et al.  Intensive Case Management Before and After Prison Release is No More Effective Than Comprehensive Pre-Release Discharge Planning in Linking HIV-Infected Prisoners to Care: A Randomized Trial , 2011, AIDS and Behavior.

[146]  P. Grant,et al.  The effect of a multidisciplinary program on HAART adherence. , 2006, AIDS patient care and STDs.

[147]  C. Sabin,et al.  Epidemiological evidence for cardiovascular disease in HIV-infected patients and relationship to highly active antiretroviral therapy. , 2008, Circulation.

[148]  M. Witt,et al.  Randomization to Once-Daily Stavudine Extended Release/Lamivudine/Efavirenz Versus a More Frequent Regimen Improves Adherence While Maintaining Viral Suppression , 2008, HIV clinical trials.

[149]  G. Marks,et al.  Entry and retention in medical care among HIV-diagnosed persons: a meta-analysis , 2010, AIDS.

[150]  J Darbyshire,et al.  CD4+ count-guided interruption of antiretroviral treatment. , 2006, The New England journal of medicine.

[151]  D. Swendeman,et al.  Prevention for Substance-Using HIV-Positive Young People: Telephone and In-Person Delivery , 2004, Journal of acquired immune deficiency syndromes.

[152]  J. J. Henning,et al.  Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents, January 28, 2000 , 1998, HIV clinical trials.

[153]  B. Yip,et al.  Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up , 2002, AIDS.

[154]  J. Cramer,et al.  Cue-dose training with monetary reinforcement: pilot study of an antiretroviral adherence intervention. , 2000, Journal of general internal medicine.

[155]  J. Parsons,et al.  Integration of motivational interviewing and cognitive behavioral therapy to improve HIV medication adherence and reduce substance use among HIV-positive men and women: results of a pilot project. , 2005, AIDS patient care and STDs.

[156]  Rhoda G. Sarnat The National Association of Social Workers. , 1956, American journal of public health and the nation's health.

[157]  E. Abrams,et al.  The Role of Psychosocial and Family Factors in Adherence to Antiretroviral Treatment in Human Immunodeficiency Virus-Infected Children , 2004, The Pediatric infectious disease journal.

[158]  R. D. Bruce,et al.  Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trial. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[159]  S. Kalichman,et al.  Nurse‐Delivered Antiretroviral Treatment Adherence Intervention for People With Low Literacy Skills and Living With HIV/AIDS , 2005, The Journal of the Association of Nurses in AIDS Care : JANAC.

[160]  D. Bangsberg,et al.  Adherence to highly active antiretroviral therapy in the homeless population in San Francisco: a prospective study. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[161]  E. Graviss,et al.  Factors associated with the use of highly active antiretroviral therapy in patients newly entering care in an urban clinic. , 2003, Journal of acquired immune deficiency syndromes.

[162]  Declan T. Barry,et al.  A trial of integrated buprenorphine/naloxone and HIV clinical care. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[163]  Richard D Moore,et al.  Directly administered antiretroviral therapy in an urban methadone maintenance clinic: a nonrandomized comparative study. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[164]  K. Jones,et al.  Early linkage and retention in care: findings from the outreach, linkage, and retention in care initiative among young men of color who have sex with men. , 2011, AIDS patient care and STDs.

[165]  B. Conway,et al.  Directly observed therapy for the management of HIV-infected patients in a methadone program. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[166]  Michele Tarsilla Cochrane Handbook for Systematic Reviews of Interventions , 2010, Journal of MultiDisciplinary Evaluation.

[167]  R. Remien,et al.  Effects of a Behavioral Intervention on Antiretroviral Medication Adherence Among People Living With HIV: The Healthy Living Project Randomized Controlled Study , 2007, Journal of acquired immune deficiency syndromes.

[168]  W. Duffus,et al.  The impact of retention in early HIV medical care on viro-immunological parameters and survival: a statewide study. , 2011, AIDS research and human retroviruses.

[169]  David R Bangsberg,et al.  Less than 95% adherence to nonnucleoside reverse-transcriptase inhibitor therapy can lead to viral suppression. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[170]  C. Farthing,et al.  Efficacy of an Individualized Adherence Support Program with Contingent Reinforcement Among Nonadherent HIV-Positive Patients , 2006, Journal of the International Association of Physicians in AIDS Care.

[171]  R. Haubrich,et al.  The Correlation between Plasma Concentrations of Protease Inhibitors, Medication Adherence and Virological Outcome in HIV-Infected Patients , 2004, Antiviral therapy.

[172]  G. Birkhead,et al.  Building an HIV continuum for inmates: New York State's criminal justice initiative. , 2002, AIDS education and prevention : official publication of the International Society for AIDS Education.

[173]  Ian M. Bennett,et al.  Medication Beliefs as Mediators of the Health Literacy–Antiretroviral Adherence Relationship in HIV-infected Individuals , 2007, AIDS and Behavior.

[174]  A. Kaplan,et al.  Availability of and Access to Medical Services Among HIV-Infected Inmates Incarcerated in North Carolina County Jails , 2004, Journal of health care for the poor and underserved.

[175]  R. D. Bruce,et al.  HIV Treatment Outcomes Among HIV-Infected, Opioid-Dependent Patients Receiving Buprenorphine/Naloxone Treatment within HIV Clinical Care Settings: Results From a Multisite Study , 2011, Journal of acquired immune deficiency syndromes.

[176]  H. Cabral,et al.  Program design and evaluation strategies for the Special Projects of National Significance Outreach Initiative. , 2007, AIDS patient care and STDs.

[177]  A. Mocroft,et al.  Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe , 2010, Journal of acquired immune deficiency syndromes.

[178]  J. Tolson,et al.  Efficacy, safety, and adherence with a twice-daily combination lamivudine/zidovudine tablet formulation, plus a protease inhibitor, in HIV infection , 2000, AIDS.

[179]  J. Baeten,et al.  Antiretroviral preexposure prophylaxis for HIV prevention. , 2013, The New England journal of medicine.

[180]  R. Chaisson,et al.  Adherence to Nonnucleoside Reverse Transcriptase InhibitorBased HIV Therapy and Virologic Outcomes , 2007, Annals of Internal Medicine.

[181]  F. Raffi,et al.  The detection of non-adherence by self-administered questionnaires can be optimized by protease inhibitor plasma concentration determination. , 2003, AIDS.

[182]  J. Simoni,et al.  A randomized controlled trial of a peer support intervention targeting antiretroviral medication adherence and depressive symptomatology in HIV-positive men and women. , 2007, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[183]  Pontali Emanuele Antiretroviral Treatment in Correctional Facilities , 2005 .

[184]  S. Marhefka,et al.  Caregiver psychosocial characteristics and children's adherence to antiretroviral therapy. , 2006, AIDS patient care and STDs.

[185]  J. Klausner,et al.  Using surveillance data to monitor entry into care of newly diagnosed HIV-infected persons: San Francisco, 2006–2007 , 2009, BMC public health.

[186]  R. Hogg,et al.  Antiretroviral adherence and HIV treatment outcomes among HIV/HCV co-infected injection drug users: the role of methadone maintenance therapy. , 2006, Drug and alcohol dependence.

[187]  Knut Dörmann,et al.  Working group 2 , 2005 .

[188]  T. Hammett,et al.  Document Title: National Survey of Infectious Diseases in Correctional Facilities: HIV and Sexually Transmitted Diseases , 2007 .

[189]  Kenneth H Mayer,et al.  A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. , 2009, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[190]  A. Zolopa,et al.  Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. , 2001, AIDS.

[191]  J. Rich,et al.  Limited Spending: An Analysis of Correctional Expenditures on Antiretrovirals for HIV-Infected Prisoners , 2007, Public health reports.

[192]  Elaine R Reynolds,et al.  Adherence to antiretroviral therapy in HIV-infected pediatric patients improves with home-based intensive nursing intervention. , 2004, AIDS patient care and STDs.

[193]  B. Stilwell,et al.  Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. 2006 revision. , 2006 .

[194]  R. Jürgens,et al.  HIV and incarceration: prisons and detention , 2011, Journal of the International AIDS Society.

[195]  V. Soriano,et al.  Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs , 2010, The Lancet.

[196]  J. Montaner,et al.  The impact of incarceration upon adherence to HIV treatment among HIV-positive injection drug users: a qualitative study , 2009, AIDS care.

[197]  H. Knobel,et al.  [Adherence to very active antiretroviral treatment: impact of individualized assessment]. , 1999, Enfermedades infecciosas y microbiologia clinica.

[198]  G. Friedland Infectious Disease Comorbidities Adversely Affecting Substance Users With HIV: Hepatitis C and Tuberculosis , 2010, Journal of acquired immune deficiency syndromes.

[199]  L. Myer,et al.  Electronic Measurement of Adherence to Pediatric Antiretroviral Therapy in South Africa , 2008, The Pediatric infectious disease journal.

[200]  J. Bradford,et al.  Retention in care of persons newly diagnosed with HIV: outcomes of the Outreach Initiative. , 2007, AIDS patient care and STDs.

[201]  A. Aceti,et al.  Directly observed therapy to treat HIV infection in prisoners. , 2000, JAMA.

[202]  E. Abrams,et al.  Pediatric HIV medication adherence: the views of medical providers from two primary care programs. , 2003, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[203]  R. Grant,et al.  Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: comparison of self-report and electronic monitoring. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[204]  L. D'Angelo,et al.  A family group approach to increasing adherence to therapy in HIV-infected youths: results of a pilot project. , 2003, AIDS patient care and STDs.

[205]  W. Hauck,et al.  Adherence to Antiretroviral Therapy by Pregnant Women Infected With Human Immunodeficiency Virus: A Pharmacy Claims‐Based Analysis , 2000, Obstetrics and gynecology.

[206]  G. V. van Servellen,et al.  Effects of a treatment adherence enhancement program on health literacy, patient-provider relationships, and adherence to HAART among low-income HIV-positive Spanish-speaking Latinos. , 2005, AIDS patient care and STDs.

[207]  A. Efron,et al.  Randomized controlled trial of trained patient-nominated treatment supporters providing partial directly observed antiretroviral therapy , 2010, AIDS.

[208]  Abigail W. Batchelder,et al.  Depression and HIV/AIDS Treatment Nonadherence: A Review and Meta-analysis , 2011, Journal of acquired immune deficiency syndromes.

[209]  S. Holmberg,et al.  Efficacy of a brief case management intervention to link recently diagnosed HIV-infected persons to care , 2005, AIDS.

[210]  Adeeba Kamarulzaman,et al.  AIDS Res Hum Retroviruses , 2006 .

[211]  Amalio Telenti,et al.  Antiretroviral Treatment of Adult HIV Infection2010 Recommendations of the International AIDS Society–USA Panel , 2010 .

[212]  Scott R. Smith,et al.  Telephone Support to Improve Antiretroviral Medication Adherence: A Multisite, Randomized Controlled Trial , 2008, Journal of acquired immune deficiency syndromes.

[213]  L. Koenig,et al.  Randomized controlled trial of an intervention to prevent adherence failure among HIV-infected patients initiating antiretroviral therapy. , 2008, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[214]  A. Moscicki,et al.  Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. , 2003, Archives of pediatrics & adolescent medicine.

[215]  L. Hurley,et al.  Effects of Depression and Selective Serotonin Reuptake Inhibitor Use on Adherence to Highly Active Antiretroviral Therapy and on Clinical Outcomes in HIV-Infected Patients , 2008, Journal of acquired immune deficiency syndromes.

[216]  W. Bilker,et al.  Effect of adherence to newly initiated antiretroviral therapy on plasma viral load , 2001, AIDS.

[217]  N. Ford,et al.  Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment , 2006, The Lancet.

[218]  J. Parienti,et al.  Effect of twice-daily nevirapine on adherence in HIV-1-infected patients: a randomized controlled study , 2007, AIDS.

[219]  M. Dubé,et al.  Inflammation and complications of HIV disease. , 2010, The Journal of infectious diseases.

[220]  Patrick M. M. Bossuyt,et al.  Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy , 2013 .

[221]  M. Carrieri,et al.  The impact of methadone or buprenorphine treatment and ongoing injection on highly active antiretroviral therapy (HAART) adherence: evidence from the MANIF2000 cohort study. , 2008, Addiction.

[222]  Shari Messinger,et al.  HIV transmission risk behaviors among HIV-infected persons who are successfully linked to care. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[223]  Richard D Moore,et al.  Directly administered antiretroviral therapy in methadone clinics is associated with improved HIV treatment outcomes, compared with outcomes among concurrent comparison groups. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[224]  E. Pontali Antiretroviral treatment in correctional facilities. , 2005, HIV Clinical Trials.

[225]  P. Bossuyt,et al.  BMC Medical Research Methodology , 2002 .

[226]  P. Tugwell,et al.  The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses , 2014 .

[227]  A. Wohl,et al.  A youth-focused case management intervention to engage and retain young gay men of color in HIV care , 2011, AIDS care.

[228]  A. Zolopa,et al.  High levels of adherence do not prevent accumulation of HIV drug resistance mutations , 2003, AIDS.

[229]  M. J. Cuevas González,et al.  A Prospective Study of Adherence and Virologic Failure in HIV-Infected Patients: Role of a Single Determination of Plasma Levels of Antiretroviral Medications , 2007, Journal of the International Association of Physicians in AIDS Care.

[230]  M. Otto,et al.  Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring. , 2001, Behaviour research and therapy.

[231]  A. Kaplan,et al.  Effect of Release from Prison and Re-Incarceration on the Viral Loads of HIV-Infected Individuals , 2005, Public health reports.

[232]  C. Zorrilla,et al.  Adherence to antiretroviral treatment among pregnant and postpartum HIV-infected women , 2008, AIDS care.

[233]  J. Davila,et al.  Centralization of HIV services in HIV-positive African-American and Hispanic youth improves retention in care , 2013, AIDS care.

[234]  S. Luchters,et al.  Short- and Long-Term Efficacy of Modified Directly Observed Antiretroviral Treatment in Mombasa, Kenya: A Randomized Trial , 2008, Journal of acquired immune deficiency syndromes.

[235]  Marilyn M. Wagener,et al.  Adherence to protease inhibitor therapy and outcomes in patients with HIV infection (vol 133, pg 21, 2000) , 2002 .

[236]  E. Kohli,et al.  Value of patient self-report and plasma human immunodeficiency virus protease inhibitor level as markers of adherence to antiretroviral therapy: relationship to virologic response. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[237]  T. Tripp,et al.  A Randomized Controlled Trial to Enhance Antiretroviral Therapy Adherence in Patients with a History of Alcohol Problems , 2005, Antiviral therapy.

[238]  C. Farthing,et al.  Results of an Antiretroviral Adherence Intervention: STAR (Staying Healthy: Taking Antiretrovirals Regularly) , 2007, Journal of the International Association of Physicians in AIDS Care.

[239]  D. Bangsberg,et al.  HIV seroprevalence among homeless and marginally housed adults in San Francisco. , 2004, American journal of public health.

[240]  J. Parsons,et al.  Situational temptation for HIV medication adherence in high-risk youth. , 2011, AIDS patient care and STDs.

[241]  M. Ryan,et al.  Directly observed antiretroviral therapy for injection drug users with HIV infection. , 2002, The AIDS reader.

[242]  Fujie Zhang,et al.  A Preliminary Randomized Controlled Trial of a Nurse-Delivered Medication Adherence Intervention Among HIV-Positive Outpatients Initiating Antiretroviral Therapy in Beijing, China , 2011, AIDS and Behavior.

[243]  R. Kronmal,et al.  Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study , 2009, AIDS.

[244]  S. Kalichman,et al.  Integrated behavioral intervention to improve HIV/AIDS treatment adherence and reduce HIV transmission. , 2011, American journal of public health.

[245]  D. Bangsberg,et al.  A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people , 2010, AIDS.

[246]  W. Jack,et al.  Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial , 2010, The Lancet.

[247]  B Clotet,et al.  Prospective Randomized Two‐Arm Controlled Study To Determine the Efficacy of a Specific Intervention To Improve Long‐Term Adherence to Highly Active Antiretroviral Therapy , 2000, Journal of acquired immune deficiency syndromes.

[248]  D. Seal HIV-related issues and concerns for imprisoned persons throughout the world , 2005, Current opinion in psychiatry.

[249]  Saad B Omer,et al.  Adherence to Highly Active Antiretroviral Therapy Assessed by Pharmacy Claims Predicts Survival in HIV-Infected South African Adults , 2006, Journal of acquired immune deficiency syndromes.

[250]  C. Bova,et al.  Home Visits to Improve Adherence to Highly Active Antiretroviral Therapy: A Randomized Controlled Trial , 2006, Journal of acquired immune deficiency syndromes.