Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease
暂无分享,去创建一个
M. Gorospe | S. Schneeweiss | J. Segal | S. Sajikumar | Sheeja Navakkode | M. Thambisetty | R. Desai | Seoyoung C. Kim | V. Varma | T. Gerhard | D. Horton | C. Anerillas | I. Schilcher | M. Mahesri | Lik-Wei Wong | T. Loeffler | Kristyn Chin | Sreedharan Sajikumar
[1] S. Schneeweiss,et al. Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Disease-Modifying Antirheumatic Agents , 2022, JAMA network open.
[2] Toshiko Tanaka,et al. A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets , 2021, Science advances.
[3] M. Link,et al. American College of Rheumatology White Paper on Antimalarial Cardiac Toxicity , 2021, Arthritis & rheumatology.
[4] G. Cutter,et al. Hydroxychloroquine for Primary Progressive Multiple Sclerosis , 2021, Annals of neurology.
[5] Archana Mishra,et al. Role of JAK/STAT in the Neuroinflammation and its Association with Neurological Disorders , 2021, Annals of neurosciences.
[6] Mohammad Zaki Bin Ibrahim,et al. Long‐term plasticity in the hippocampus: maintaining within and ‘tagging’ between synapses , 2021, The FEBS journal.
[7] John F. Ouyang,et al. Transcriptional signature in microglia associated with Aβ plaque phagocytosis , 2021, Nature Communications.
[8] S. Schneeweiss,et al. Conducting Real-world Evidence Studies on the Clinical Outcomes of Diabetes Treatments , 2021, Endocrine reviews.
[9] A. Brickman,et al. Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis , 2021, BMJ.
[10] D. Wang,et al. Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications , 2020, Molecular neurobiology.
[11] George Hripcsak,et al. Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study , 2020, The Lancet Rheumatology.
[12] F. Reggiori,et al. Hydroxychloroquine in rheumatic autoimmune disorders and beyond , 2020, EMBO molecular medicine.
[13] S. Sajikumar,et al. Regulation of aberrant proteasome activity re‐establishes plasticity and long‐term memory in an animal model of Alzheimer's disease , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[14] S. Schneeweiss,et al. Measuring Frailty in Administrative Claims Data: Comparative Performance of Four Claims-Based Frailty Measures in the United States Medicare Data. , 2019, The journals of gerontology. Series A, Biological sciences and medical sciences.
[15] Guoan Chen,et al. Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation. , 2020, Life sciences.
[16] Moonseok Choi,et al. Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease. , 2020, Journal of pharmacological sciences.
[17] S. Schneeweiss,et al. Targeting abnormal metabolism in Alzheimer's disease: The Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study , 2020, Alzheimer's & dementia.
[18] V. Zachariou,et al. Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research , 2019, Biomedicines.
[19] S. Lai,et al. Chronic hydroxychloroquine exposure and the risk of Alzheimer’s disease , 2019, Annals of the Rheumatic Diseases.
[20] D. Mango,et al. Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease , 2019, Front. Pharmacol..
[21] S. Schneeweiss,et al. Using Real-World Data to Predict Findings of an Ongoing Phase IV Cardiovascular Outcome Trial: Cardiovascular Safety of Linagliptin Versus Glimepiride , 2019, Diabetes Care.
[22] S. Sajikumar,et al. The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation , 2019, The Journal of Neuroscience.
[23] S. Lovestone,et al. Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer’s Disease Therapeutic Development , 2019, Cells.
[24] A. Halle,et al. Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model , 2019, EMBO molecular medicine.
[25] M. Mattson,et al. Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons , 2018, Cell Death & Differentiation.
[26] E. Perfetto,et al. Predicting Diagnosis of Alzheimer’s Disease and Related Dementias Using Administrative Claims , 2018, Journal of managed care & specialty pharmacy.
[27] I. Petersen,et al. Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer’s disease: a population-based cohort study , 2018, Annals of the rheumatic diseases.
[28] N. Reynolds,et al. Steady-state pharmacokinetics of hydroxychloroquine in patients with cutaneous lupus erythematosus , 2018, Lupus.
[29] S. Sajikumar,et al. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer’s disease , 2017, Proceedings of the National Academy of Sciences.
[30] JA Rassen,et al. Transparency and Reproducibility of Observational Cohort Studies Using Large Healthcare Databases. , 2016, Clinical pharmacology and therapeutics.
[31] Jason P. Fine,et al. Statistical Primer for Cardiovascular Research Introduction to the Analysis of Survival Data in the Presence of Competing Risks , 2022 .
[32] P. Cheah,et al. Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain , 2016, Neural plasticity.
[33] S. Sajikumar,et al. Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents , 2015, Journal of visualized experiments : JoVE.
[34] Sudha Seshadri,et al. Development and validation of a brief dementia screening indicator for primary care , 2014, Alzheimer's & Dementia.
[35] J. Cummings,et al. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures , 2014, Alzheimer's Research & Therapy.
[36] Jeremy A Rassen,et al. Metrics for covariate balance in cohort studies of causal effects , 2014, Statistics in medicine.
[37] H. Soininen,et al. Validity of dementia and Alzheimer's disease diagnoses in Finnish national registers , 2014, Alzheimer's & Dementia.
[38] D. Browning. Pharmacology of Chloroquine and Hydroxychloroquine , 2014, Hydroxychloroquine and Chloroquine Retinopathy.
[39] Richard Platt,et al. A tool for assessing the feasibility of comparative effectiveness research , 2013 .
[40] G. Collingridge,et al. The role of JAK-STAT signaling within the CNS , 2013, JAK-STAT.
[41] Abhi Shelat,et al. One‐to‐many propensity score matching in cohort studies , 2012, Pharmacoepidemiology and drug safety.
[42] Sebastian Schneeweiss,et al. Multivariate‐adjusted pharmacoepidemiologic analyses of confidential information pooled from multiple health care utilization databases , 2010, Pharmacoepidemiology and drug safety.
[43] G. Landreth,et al. The role of microglia in amyloid clearance from the AD brain , 2010, Journal of Neural Transmission.
[44] Zhenguo Wu,et al. Tyk2/STAT3 Signaling Mediates β-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease , 2010, The Journal of Neuroscience.
[45] J. Pontén,et al. The ultrastructure of human and murine astrocytes and of human fibroblasts in culture. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.
[46] Peter C Austin,et al. Some Methods of Propensity‐Score Matching had Superior Performance to Others: Results of an Empirical Investigation and Monte Carlo simulations , 2009, Biometrical journal. Biometrische Zeitschrift.
[47] J. Avorn,et al. Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect. , 2007, American journal of epidemiology.
[48] Hilkka Soininen,et al. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study , 2006, The Lancet Neurology.
[49] Sreedharan Sajikumar,et al. Protein synthesis-dependent long-term functional plasticity: methods and techniques , 2005, Current Opinion in Neurobiology.
[50] M. Bear,et al. LTP and LTD An Embarrassment of Riches , 2004, Neuron.
[51] Dominic M. Walsh,et al. Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease , 2004, Neuron.
[52] D. Selkoe. Alzheimer's Disease Is a Synaptic Failure , 2002, Science.
[53] W. K. Cullen,et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.
[54] M Maclure,et al. Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. , 2001, American journal of epidemiology.
[55] P. Scheltens,et al. Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study , 2001, The Lancet.
[56] R Brookmeyer,et al. Age-specific incidence rates of Alzheimer’s disease , 2000, Neurology.
[57] D. Borchelt,et al. Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins , 1997, Neuron.
[58] T. Bliss,et al. A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.
[59] R. Day,et al. Bioavailability of hydroxychloroquine tablets in healthy volunteers. , 1989, British journal of clinical pharmacology.
[60] A. Mackenzie,et al. Pharmacologic actions of 4-aminoquinoline compounds. , 1983, The American journal of medicine.
[61] D. Rubin,et al. The central role of the propensity score in observational studies for causal effects , 1983 .
[62] Guy B. Williams,et al. Genetic and Real-World Clinical Data , Combined with Empirical Validation , Nominate Jak-Stat Signaling as a Target for Alzheimer ’ s Disease Therapeutic Development , 2019 .
[63] Sebastian Schneeweiss,et al. Use of Health Care Databases to Support Supplemental Indications of Approved Medications , 2018, JAMA internal medicine.
[64] Truls Østbye,et al. The accuracy of Medicare claims as an epidemiological tool: the case of dementia revisited. , 2009, Journal of Alzheimer's disease : JAD.