DNA methylation abnormalities induced by advanced maternal age in villi prime a high-risk state for spontaneous abortion

[1]  Liying Yan,et al.  The combination of DNA methylome and transcriptome revealed the intergenerational inheritance on the influence of advanced maternal age , 2022, Clinical and translational medicine.

[2]  J. Pollheimer,et al.  WNT and NOTCH signaling in human trophoblast development and differentiation , 2022, Cellular and Molecular Life Sciences.

[3]  V. Gladyshev,et al.  In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan , 2022, Nature Aging.

[4]  G. Coticchio,et al.  Oocyte aging: looking beyond chromosome segregation errors , 2022, Journal of Assisted Reproduction and Genetics.

[5]  D. Liebermann,et al.  Gadd45 in Senescence. , 2022, Advances in experimental medicine and biology.

[6]  K. Nho,et al.  Genome-wide association study of occupational attainment as a proxy for cognitive reserve. , 2021, Brain : a journal of neurology.

[7]  Alan Brown,et al.  De novo identification of mammalian ciliary motility proteins using cryo-EM , 2021, Cell.

[8]  M. Kilby,et al.  Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial−Mesenchymal Transition through an Increase in Vimentin Acetylation , 2021, Aging cell.

[9]  H. Neumann,et al.  Gne deletion in mice leads to lethal intracerebral hemorrhage during embryonic development. , 2021, Glycobiology.

[10]  M. Kilby,et al.  Advanced maternal age causes premature placental senescence and malformation via dysregulated α‐Klotho expression in trophoblasts , 2021, Aging cell.

[11]  Wuwen Zhang,et al.  Single‐cell transcriptome analysis of human oocyte ageing , 2021, Journal of cellular and molecular medicine.

[12]  Bin Wang,et al.  Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss , 2021, Genes & Genomics.

[13]  P. Leung,et al.  Roles of TGF-β Superfamily Proteins in Extravillous Trophoblast Invasion , 2021, Trends in Endocrinology & Metabolism.

[14]  Jing Qu,et al.  Aging Atlas: a multi-omics database for aging biology , 2020, Nucleic Acids Res..

[15]  OUP accepted manuscript , 2021, Human Reproduction Update.

[16]  Liying Yan,et al.  Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring , 2020, EBioMedicine.

[17]  A. Frick.  Advanced maternal age and adverse pregnancy outcomes. , 2020, Best practice & research. Clinical obstetrics & gynaecology.

[18]  Qi Zhou,et al.  Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. , 2020, Cell stem cell.

[19]  Guy C. Brown,et al.  Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration , 2020, Frontiers in Cellular Neuroscience.

[20]  G. Kelsey,et al.  A distinctive epigenetic ageing profile in human granulosa cells. , 2020, Human reproduction.

[21]  J. C. Belmonte,et al.  Single-cell omics in ageing: a young and growing field , 2020, Nature metabolism.

[22]  Y. Salameh,et al.  DNA Methylation Biomarkers in Aging and Age-Related Diseases , 2020, Frontiers in Genetics.

[23]  C. Hao,et al.  Advanced maternal age alters expression of maternal effect genes that are essential for human oocyte quality , 2020, Aging.

[24]  B. Mol,et al.  Risk of adverse pregnancy outcomes of late‐ and postterm pregnancies in advanced maternal age: A national cohort study , 2020, Acta obstetricia et gynecologica Scandinavica.

[25]  H. Neumann,et al.  Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice , 2020, Neurobiology of Aging.

[26]  Alison S Care,et al.  Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats , 2019, Scientific Reports.

[27]  E. Heard,et al.  Advances in epigenetics link genetics to the environment and disease , 2019, Nature.

[28]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[29]  V. Ashapkin,et al.  Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging? , 2019, Front. Genet..

[30]  Aaron M. Moore,et al.  Persistent epigenetic changes in adult daughters of older mothers , 2019, Epigenetics.

[31]  C. Weinberg,et al.  Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study , 2019, BMJ.

[32]  D. Balding,et al.  A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia , 2019, Nature Communications.

[33]  A. Kispert,et al.  Sialic acid is a critical fetal defense against maternal complement attack , 2018, The Journal of clinical investigation.

[34]  Michael J. T. Stubbington,et al.  Single-cell reconstruction of the early maternal–fetal interface in humans , 2018, Nature.

[35]  A. Prentice,et al.  Establishment of environmentally sensitive DNA methylation states in the very early human embryo , 2018, Science Advances.

[36]  L. Rienzi,et al.  Impact of Maternal Age on Oocyte and Embryo Competence , 2018, Front. Endocrinol..

[37]  I. Blickstein,et al.  Is forty the new thirty? Population based study of advanced maternal age , 2018, Journal of perinatal medicine.

[38]  Steve Horvath,et al.  DNA methylation-based biomarkers and the epigenetic clock theory of ageing , 2018, Nature Reviews Genetics.

[39]  C. Ekelund,et al.  Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age. , 2018, Obstetrics and gynecology.

[40]  M. Hemberger,et al.  Decidualisation and placentation defects are a major cause of age-related reproductive decline , 2017, Nature Communications.

[41]  A. Heazell,et al.  Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women , 2017, Scientific Reports.

[42]  Tsukasa Suzuki,et al.  Maternal H3K27me3 controls DNA methylation-independent genomic imprinting , 2017, Nature.

[43]  S. Cnattingius,et al.  Advanced maternal age increases the risk of very preterm birth, irrespective of parity: a population‐based register study , 2017, BJOG : an international journal of obstetrics and gynaecology.

[44]  J. Li,et al.  Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion , 2016, The journal of obstetrics and gynaecology research.

[45]  Paola,et al.  Analysis of the machinery and intermediates of the 5 hmC ‐ mediated DNA demethylation pathway in aging on samples from the , 2016 .

[46]  Bonnie R. Joubert,et al.  Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults , 2016, PloS one.

[47]  Andrei L. Turinsky,et al.  Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction , 2016, Clinical Epigenetics.

[48]  Rui Hua,et al.  In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy , 2016, Proceedings of the National Academy of Sciences.

[49]  Florian Hahne,et al.  Visualizing Genomic Data Using Gviz and Bioconductor , 2016, Statistical Genomics.

[50]  Tin-Lap Lee,et al.  Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging. , 2015, The international journal of biochemistry & cell biology.

[51]  A. Guidotti,et al.  Gadd45b and N-methyl-D-aspartate induced DNA demethylation in postmitotic neurons. , 2015, Epigenomics.

[52]  M. Sauer.  Reproduction at an advanced maternal age and maternal health. , 2015, Fertility and sterility.

[53]  M. Kobor,et al.  DNA methylation and healthy human aging , 2015, Aging cell.

[54]  R. Krisher,et al.  Dysregulation of methylation and expression of imprinted genes in oocytes and reproductive tissues in mice of advanced maternal age , 2015, Journal of Assisted Reproduction and Genetics.

[55]  Stephen W. Hartley,et al.  DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3ʹ-end GC density , 2015, Oncotarget.

[56]  M. Huizing,et al.  UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis. , 2015, Topics in current chemistry.

[57]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[58]  Wei Shi,et al.  featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..

[59]  Thomas Craig,et al.  LongevityMap: a database of human genetic variants associated with longevity. , 2013, Trends in genetics : TIG.

[60]  M. Carolan.  Maternal age ≥45 years and maternal and perinatal outcomes: a review of the evidence. , 2013, Midwifery.

[61]  T. Ideker,et al.  Genome-wide methylation profiles reveal quantitative views of human aging rates. , 2013, Molecular cell.

[62]  R. Harris,et al.  Human metastable epiallele candidates link to common disorders , 2013, Epigenetics.

[63]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[64]  Shi-ling Chen,et al.  Aberrant DNA methylation of imprinted loci in human spontaneous abortions after assisted reproduction techniques and natural conception. , 2013, Human reproduction.

[65]  Francine E. Garrett-Bakelman,et al.  methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles , 2012, Genome Biology.

[66]  Peter A. Jones.  Functions of DNA methylation: islands, start sites, gene bodies and beyond , 2012, Nature Reviews Genetics.

[67]  Yunpeng Hou,et al.  Abnormal DNA methylation in oocytes could be associated with a decrease in reproductive potential in old mice , 2012, Journal of Assisted Reproduction and Genetics.

[68]  P. Schlag,et al.  Loss of UDP‐N‐acetylglucosamine 2‐epimerase/N‐acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[69]  A. Zhavoronkov,et al.  Gadd45 proteins: Relevance to aging, longevity and age-related pathologies , 2012, Ageing Research Reviews.

[70]  Felix Krueger,et al.  Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications , 2011, Bioinform..

[71]  R. Yuen,et al.  Review: A high capacity of the human placenta for genetic and epigenetic variation: implications for assessing pregnancy outcome. , 2011, Placenta.

[72]  Jian-Kang Zhu,et al.  Regulation and function of DNA methylation in plants and animals , 2011, Cell Research.

[73]  S. Apostolidou,et al.  Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction. , 2011, Placenta.

[74]  Julia Krushkal,et al.  Parental ages and levels of DNA methylation in the newborn are correlated , 2011, BMC Medical Genetics.

[75]  R. Saffery,et al.  DNA methylation profiling highlights the unique nature of the human placental epigenome. , 2010, Epigenomics.

[76]  D. Newgreen,et al.  Cadherins in the human placenta--epithelial-mesenchymal transition (EMT) and placental development. , 2010, Placenta.

[77]  E. Gibney,et al.  Epigenetics and gene expression , 2010, Heredity.

[78]  P. von Dadelszen,et al.  Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia. , 2010, Placenta.

[79]  J. Campisi,et al.  The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.

[80]  Gonçalo R. Abecasis,et al.  The Sequence Alignment/Map format and SAMtools , 2009, Bioinform..

[81]  Joachim Selbig,et al.  pcaMethods - a bioconductor package providing PCA methods for incomplete data , 2007, Bioinform..

[82]  D. Nelson,et al.  Advanced maternal age is an independent risk factor for intrauterine growth restriction. , 2006, American journal of perinatology.

[83]  V. Giordanengo,et al.  Epigenetic reprogramming of UDP‐N‐acetylglucosamine 2‐ epimerase/N‐acetylmannosamine kinase (GNE) in HIV‐1‐ infected CEM T cells , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[84]  L. Heffner.  Advanced maternal age--how old is too old? , 2004, The New England journal of medicine.

[85]  L. Simkens,et al.  Aging Blunts Remodeling of the Uterine Artery During Murine Pregnancy , 2004, The Journal of the Society for Gynecologic Investigation: JSGI.

[86]  K. Knobeloch,et al.  Sialylation is essential for early development in mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.