Stress Response Proteins and Modulation of Cell Death

Severe environmental stress induces cell death. This is of ten associated with the upregulation of stress response proteins including endoplasmic reticulum (ER) stress proteins like the glucose regulated proteins (GRPs) GRP78 and GRP94. Upregulation of these proteins provides a tolerance phenotype against a variety of subsequent lethal conditions. The exact mechanism of the upregulation of these ER stress proteins, their role in protection against cell death and the mechanism of their protection will be discussed.

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