Induced pluripotent stem cell technology: a decade of progress

[1]  Krishanu Saha,et al.  Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells , 2017, Stem cells.

[2]  Evgenios Neofytou,et al.  Potential Strategies to Address the Major Clinical Barriers Facing Stem Cell Regenerative Therapy for Cardiovascular Disease: A Review. , 2016, JAMA cardiology.

[3]  Michael P Snyder,et al.  Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. , 2016, Cell stem cell.

[4]  Yusuke Inoue,et al.  Current Public Support for Human-Animal Chimera Research in Japan Is Limited, Despite High Levels of Scientific Approval. , 2016, Cell stem cell.

[5]  T. Townes,et al.  Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction , 2016, Scientific Reports.

[6]  Zayd M. Khaliq,et al.  A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism , 2016, The Journal of Neuroscience.

[7]  Mackenzie W. Mathis,et al.  ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks , 2016, Nature Neuroscience.

[8]  A. Riggs,et al.  Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes , 2016, Cell reports.

[9]  F. Gage,et al.  Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain , 2016, Neuron.

[10]  F. Gage,et al.  Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience , 2016, Nature Reviews Neuroscience.

[11]  G. Gintant,et al.  Evolution of strategies to improve preclinical cardiac safety testing , 2016, Nature Reviews Drug Discovery.

[12]  Megan Scudellari.  How iPS cells changed the world , 2016, Nature.

[13]  David W. Nauen,et al.  Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure , 2016, Cell.

[14]  P. Garcez,et al.  Zika virus impairs growth in human neurospheres and brain organoids , 2016, Science.

[15]  Amadou A. Sall,et al.  The Brazilian Zika virus strain causes birth defects in experimental models , 2016, Nature.

[16]  M. Deleidi,et al.  Genome editing in pluripotent stem cells: research and therapeutic applications. , 2016, Biochemical and biophysical research communications.

[17]  R. Jaenisch,et al.  Induced Pluripotent Stem Cells Meet Genome Editing. , 2016, Cell stem cell.

[18]  Marc Tessier-Lavigne,et al.  Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9 , 2016, Nature.

[19]  J. Rapoport,et al.  Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. , 2016, Cell reports.

[20]  M. Dehouck,et al.  Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery. , 2016, Trends in biotechnology.

[21]  Jason R Spence,et al.  Organoid Models of Human Gastrointestinal Development and Disease. , 2016, Gastroenterology.

[22]  Nazish Sayed,et al.  Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine. , 2016, Journal of the American College of Cardiology.

[23]  R. W. Hansen,et al.  Journal of Health Economics , 2016 .

[24]  David R. Liu,et al.  Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage , 2016, Nature.

[25]  Nevan J Krogan,et al.  CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. , 2016, Cell stem cell.

[26]  F. Gage,et al.  2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size , 2016, Cell stem cell.

[27]  Yonatan Stelzer,et al.  Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression , 2016, Nature.

[28]  G. Howell,et al.  Toward more predictive genetic mouse models of Alzheimer's disease , 2016, Brain Research Bulletin.

[29]  Giulia Fragola,et al.  Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration , 2016, Nature Communications.

[30]  A. Riggs,et al.  The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model , 2016, Nature Communications.

[31]  A. Trounson,et al.  Pluripotent stem cells progressing to the clinic , 2016, Nature Reviews Molecular Cell Biology.

[32]  S. Yamanaka,et al.  A decade of transcription factor-mediated reprogramming to pluripotency , 2016, Nature Reviews Molecular Cell Biology.

[33]  N. Benvenisty,et al.  Pluripotent stem cells in disease modelling and drug discovery , 2016, Nature Reviews Molecular Cell Biology.

[34]  Nick Barker,et al.  Organoids as an in vitro model of human development and disease , 2016, Nature Cell Biology.

[35]  A. Hyman,et al.  CPAP promotes timely cilium disassembly to maintain neural progenitor pool , 2016, The EMBO journal.

[36]  J. C. Love,et al.  Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes , 2016, The Journal of Neuroscience.

[37]  Praveen Shukla,et al.  Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies. , 2016, Advanced drug delivery reviews.

[38]  M. Eiraku,et al.  Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells , 2016, Nature Communications.

[39]  A. Connolly,et al.  Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas , 2016, Stem Cell Reports.

[40]  Jeffrey M Karp,et al.  Engineering Stem Cell Organoids. , 2016, Cell stem cell.

[41]  F. Pereyra-Bonnet,et al.  iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System , 2016, Stem cells international.

[42]  David A. Scott,et al.  Rationally engineered Cas9 nucleases with improved specificity , 2015, Science.

[43]  K. Eggan,et al.  10 Questions: Clinical Outlook for iPSCs. , 2016, Cell stem cell.

[44]  Lei S. Qi,et al.  Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation , 2016, Nature Reviews Molecular Cell Biology.

[45]  Madeline A. Lancaster,et al.  Human cerebral organoids recapitulate gene expression programs of fetal neocortex development , 2015, Proceedings of the National Academy of Sciences.

[46]  Jürgen Winkler,et al.  Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. , 2015, Cell stem cell.

[47]  S. Yamanaka,et al.  From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing. , 2015, Annual review of genetics.

[48]  Jian Xu,et al.  Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges , 2015, International journal of molecular sciences.

[49]  Yoshiki Sasai,et al.  Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue , 2015, Nature Communications.

[50]  J. Nurnberger,et al.  Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder , 2015, Nature.

[51]  Beau R. Webber,et al.  In Vitro T‐Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination , 2015, Stem cells.

[52]  Huan Wang,et al.  Transdifferentiation via transcription factors or microRNAs: Current status and perspective. , 2015, Differentiation; research in biological diversity.

[53]  A. Consiglio,et al.  Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients , 2015, EMBO molecular medicine.

[54]  S. Lopes,et al.  Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis , 2015, Nature.

[55]  Robert Lanza,et al.  Current status of pluripotent stem cells: moving the first therapies to the clinic , 2015, Nature Reviews Drug Discovery.

[56]  C. David Page,et al.  Human pluripotent stem cell-derived neural constructs for predicting neural toxicity , 2015, Proceedings of the National Academy of Sciences.

[57]  Bon-Kyoung Koo,et al.  Modeling mouse and human development using organoid cultures , 2015, Development.

[58]  Chia-wei Chang,et al.  Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting. , 2015, Cell reports.

[59]  D. Clegg,et al.  Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. , 2015, Cell stem cell.

[60]  F. Gage,et al.  Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. , 2015, Cell reports.

[61]  Yusheng Qu,et al.  Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[62]  Asher Mullard.  Stem-cell discovery platforms yield first clinical candidates , 2015, Nature Reviews Drug Discovery.

[63]  N. Fujii,et al.  Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells , 2015, Scientific Reports.

[64]  E. Tartour,et al.  Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report. , 2015, European heart journal.

[65]  Jin-Soo Kim,et al.  Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9. , 2015, Cell stem cell.

[66]  R. Jaenisch,et al.  Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation , 2015, Nature Communications.

[67]  M. Gerstein,et al.  FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders , 2015, Cell.

[68]  Shinichiro Ogawa,et al.  Directed differentiation of cholangiocytes from human pluripotent stem cells , 2015, Nature Biotechnology.

[69]  T. Karlsen,et al.  Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation , 2015, Nature Biotechnology.

[70]  Kevin Eggan,et al.  From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. , 2015, Cell stem cell.

[71]  Wenwei Huang,et al.  High‐Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient‐Derived Induced Pluripotent Stem Cells , 2015, Stem cells translational medicine.

[72]  Larry A Couture,et al.  Hurdles to clinical translation of human induced pluripotent stem cells. , 2015, The Journal of clinical investigation.

[73]  D. Geschwind,et al.  Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture , 2015, Nature Methods.

[74]  P. Loria,et al.  Developing predictive assays: The phenotypic screening “rule of 3” , 2015, Science Translational Medicine.

[75]  A. Palmeri,et al.  Rodent models for Alzheimer’s disease drug discovery , 2015, Expert opinion on drug discovery.

[76]  Shinya Yamanaka,et al.  Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches. , 2015, Cell stem cell.

[77]  Elsa Vera,et al.  Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. , 2015, Cell stem cell.

[78]  T. Bouwmeester,et al.  High-Throughput Screening Using iPSC-Derived Neuronal Progenitors to Identify Compounds Counteracting Epigenetic Gene Silencing in Fragile X Syndrome , 2015, Journal of biomolecular screening.

[79]  Jerry Avorn,et al.  The $2.6 billion pill--methodologic and policy considerations. , 2015, The New England journal of medicine.

[80]  K. Blennow,et al.  APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons , 2015, Cell reports.

[81]  F. Gage,et al.  Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro , 2015, Proceedings of the National Academy of Sciences.

[82]  Steven D. Edland,et al.  Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. , 2015, Cell stem cell.

[83]  M. Rao,et al.  Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines , 2015, Stem cell reports.

[84]  Gail H Deutsch,et al.  In vitro generation of human pluripotent stem cell derived lung organoids , 2015, eLife.

[85]  James Adjaye,et al.  Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks , 2015, BMC Genomics.

[86]  Hideshi Kawakami,et al.  Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. , 2015, Cell reports.

[87]  G. Parry,et al.  Human secreted tau increases amyloid-beta production , 2015, Neurobiology of Aging.

[88]  J. D. Foster,et al.  Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability , 2015, Nature Communications.

[89]  S. Ge,et al.  Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC‐Derived Human Neurons , 2015, Stem cells.

[90]  F. Gage,et al.  Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia , 2014, Molecular Psychiatry.

[91]  C. Bravery.  Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense? , 2015, Stem cells and development.

[92]  Rudolph E. Tanzi,et al.  Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. , 2014, JAMA neurology.

[93]  David W. Nauen,et al.  Synaptic dysregulation in a human iPS cell model of mental disorders , 2014, Nature.

[94]  Eric E Schadt,et al.  iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. , 2014, Cell reports.

[95]  Ying Sun,et al.  An in vivo model of human small intestine using pluripotent stem cells , 2014, Nature Medicine.

[96]  S. Ikegawa,et al.  Statin treatment rescues FGFR3 skeletal dysplasia phenotypes , 2014, Nature.

[97]  Carlos Cruchaga,et al.  Identification of rare variants in Alzheimer’s disease , 2014, Front. Genet..

[98]  Michael Schumacher,et al.  Modeling human development and disease in pluripotent stem cell-derived gastric organoids , 2014, Nature.

[99]  Anirvan Ghosh,et al.  SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy , 2014, Science.

[100]  H. Nakauchi,et al.  Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease , 2014 .

[101]  Juergen A. Knoblich,et al.  Organogenesis in a dish: Modeling development and disease using organoid technologies , 2014, Science.

[102]  Elias T. Zambidis,et al.  Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties. , 2014, Stem cells and development.

[103]  Kun Zhang,et al.  Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs. , 2014, Cell stem cell.

[104]  David W. Nauen,et al.  Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. , 2014, Cell stem cell.

[105]  Chad A. Cowan,et al.  Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. , 2014, Cell stem cell.

[106]  D. Selkoe,et al.  The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. , 2014, Human molecular genetics.

[107]  S. Gygi,et al.  iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis , 2014, Nature Communications.

[108]  H. Goodridge.  Induced pluripotent stem cell-derived myeloid phagocytes: disease modeling and therapeutic applications. , 2014, Drug discovery today.

[109]  Daniel T. Montoro,et al.  Transplanted Terminally Differentiated Induced Pluripotent Stem Cells Are Accepted By Immune Mechanisms Similar To Self-Tolerance , 2014, Nature Communications.

[110]  Christine A. Wells,et al.  Single-Cell Gene Expression Profiles Define Self-Renewing, Pluripotent, and Lineage Primed States of Human Pluripotent Stem Cells , 2014, Stem cell reports.

[111]  Robert H. Brown,et al.  Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. , 2014, Cell reports.

[112]  Chunhui Xu,et al.  In vitro organogenesis from pluripotent stem cells , 2014, Organogenesis.

[113]  K. Sekiguchi,et al.  Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation , 2014, Stem cell reports.

[114]  Shinya Yamanaka,et al.  iPS cells: a game changer for future medicine , 2014, The EMBO journal.

[115]  Yilong Li,et al.  Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library , 2013, Nature Biotechnology.

[116]  Richard Wade-Martins,et al.  Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons , 2014, PloS one.

[117]  Nobutaka Hattori,et al.  Cerebral organoids model human brain development and microcephaly , 2014, Movement disorders : official journal of the Movement Disorder Society.

[118]  A. Robin,et al.  Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma , 2014, Journal of stem cell research & therapy.

[119]  Jin-Soo Kim,et al.  Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases , 2014, Bioinform..

[120]  G. Pan,et al.  Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response , 2014, Science China Life Sciences.

[121]  Neville E. Sanjana,et al.  Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells , 2014, Science.

[122]  J. Kessler,et al.  Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death , 2014, Molecular Neurodegeneration.

[123]  Luke A. Gilbert,et al.  Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System , 2013, Cell.

[124]  D. Krainc,et al.  Human iPSC-based modeling of late-onset disease via progerin-induced aging. , 2013, Cell stem cell.

[125]  J. Mertens,et al.  APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation , 2013, Stem cell reports.

[126]  John R. Yates,et al.  Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription , 2013, Cell.

[127]  Kun Zhang,et al.  The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. , 2013, Cell reports.

[128]  M. Eiraku,et al.  Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex , 2013, Proceedings of the National Academy of Sciences.

[129]  T. Ichisaka,et al.  Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells , 2013, Proceedings of the National Academy of Sciences.

[130]  David A. Scott,et al.  Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity , 2013, Cell.

[131]  James W Kramer,et al.  Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. , 2013, Toxicology and applied pharmacology.

[132]  Michael D. Pluth,et al.  Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons , 2013, Science.

[133]  R. Martinez,et al.  A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells , 2013, Molecular and Cellular Neuroscience.

[134]  H. Deng,et al.  Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds , 2013, Science.

[135]  S. Moon,et al.  Inhibition of pluripotent stem cell-derived teratoma formation by small molecules , 2013, Proceedings of the National Academy of Sciences.

[136]  N. McMahon,et al.  Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[137]  I. Weissman,et al.  Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies , 2013, Nature Medicine.

[138]  Christopher M. Vockley,et al.  RNA-guided gene activation by CRISPR-Cas9-based transcription factors , 2013, Nature Methods.

[139]  Takanori Takebe,et al.  Vascularized and functional human liver from an iPSC-derived organ bud transplant , 2013, Nature.

[140]  J. Keith Joung,et al.  High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells , 2013, Nature Biotechnology.

[141]  Y. Sasai.  Next-generation regenerative medicine: organogenesis from stem cells in 3D culture. , 2013, Cell stem cell.

[142]  N. Fujii,et al.  Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro , 2013, PloS one.

[143]  Katsuhiro Yoshikawa,et al.  Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. , 2013, Cell stem cell.

[144]  Torsten Kluba,et al.  Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. , 2013, Cell stem cell.

[145]  Zhong Zhong,et al.  Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events. , 2013, Stem cell research.

[146]  Seung Woo Cho,et al.  Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease , 2013, Nature Biotechnology.

[147]  James E. DiCarlo,et al.  RNA-Guided Human Genome Engineering via Cas9 , 2013, Science.

[148]  O. Yanuka,et al.  Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. , 2013, Cell stem cell.

[149]  Le Cong,et al.  Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.

[150]  Jennifer Doudna,et al.  RNA-programmed genome editing in human cells , 2013, eLife.

[151]  Yoshiki Sasai,et al.  Cytosystems dynamics in self-organization of tissue architecture , 2013, Nature.

[152]  R. Vaughan,et al.  Strategy for the creation of clinical grade hESC line banks that HLA-match a target population , 2012, EMBO molecular medicine.

[153]  Mark M. Davis,et al.  Pluripotent Stem Cells: Immune to the Immune System? , 2012, Science Translational Medicine.

[154]  L. Studer,et al.  Identification of Compounds that Rescue IKBKAP Expression in Familial Dysautonomia-iPS Cells , 2012, Nature Biotechnology.

[155]  Alexander Böcker,et al.  Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay. , 2012, Cell stem cell.

[156]  H. Okano,et al.  Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue , 2012, Molecular Brain.

[157]  R. Lahesmaa,et al.  Genetic and epigenetic stability of human pluripotent stem cells , 2012, Nature Reviews Genetics.

[158]  J. Yates,et al.  Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 , 2012, Nature.

[159]  J. Doudna,et al.  A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , 2012, Science.

[160]  H. Hioki,et al.  Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells , 2012, Science Translational Medicine.

[161]  K. Moore,et al.  Reprogramming cell fates: insights from combinatorial approaches , 2012, Annals of the New York Academy of Sciences.

[162]  Christine Klein,et al.  Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease , 2012, Science Translational Medicine.

[163]  N. Benvenisty,et al.  Expanding the boundaries of embryonic stem cells. , 2012, Cell stem cell.

[164]  Yoshiki Sasai,et al.  Self-formation of optic cups and storable stratified neural retina from human ESCs. , 2012, Cell stem cell.

[165]  S. Yamanaka.  Induced pluripotent stem cells: past, present, and future. , 2012, Cell stem cell.

[166]  M. Memo,et al.  Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease , 2012, EMBO molecular medicine.

[167]  Zhen Yan,et al.  Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells , 2012, Nature Communications.

[168]  Kristopher L. Nazor,et al.  Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells , 2012, Nature.

[169]  H. Okano,et al.  [Modeling familial Alzheimer's disease with induced pluripotent stem cells]. , 2012, Rinsho shinkeigaku = Clinical neurology.

[170]  Takao Hayakawa,et al.  Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[171]  Neville E Sanjana,et al.  A transcription activator-like effector toolbox for genome engineering , 2012, Nature Protocols.

[172]  Andrew P. Feinberg,et al.  Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells , 2011, Nature Biotechnology.

[173]  Fred H. Gage,et al.  Modelling schizophrenia using human induced pluripotent stem cells , 2011, Nature.

[174]  Shinya Yamanaka,et al.  Immunogenicity of induced pluripotent stem cells. , 2011, Circulation research.

[175]  D. Zheng,et al.  RNA-Seq of Human Neurons Derived from iPS Cells Reveals Candidate Long Non-Coding RNAs Involved in Neurogenesis and Neuropsychiatric Disorders , 2011, PloS one.

[176]  Patrick A. Lewis,et al.  Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus , 2011, Nature communications.

[177]  J. Mendell,et al.  Astrocytes from Familial and Sporadic ALS Patients are Toxic to Motor Neurons , 2011, Nature Biotechnology.

[178]  N. Benvenisty,et al.  Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. , 2011, Cell stem cell.

[179]  Mitsugu Sekimoto,et al.  Reprogramming of mouse and human cells to pluripotency using mature microRNAs. , 2011, Cell stem cell.

[180]  S. Yamanaka,et al.  The Use of Induced Pluripotent Stem Cells in Drug Development , 2011, Clinical pharmacology and therapeutics.

[181]  Jun S. Song,et al.  Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells , 2011, Nature Cell Biology.

[182]  Yasuko Matsumura,et al.  A more efficient method to generate integration-free human iPS cells , 2011, Nature Methods.

[183]  D. Krainc,et al.  Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells , 2011, The Journal of Neuroscience.

[184]  Mark M. Davis,et al.  Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. , 2011, Cell stem cell.

[185]  Blake Byers,et al.  LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. , 2011, Cell stem cell.

[186]  Jarrett Rosenberg,et al.  Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. , 2011, The Journal of clinical investigation.

[187]  Elizabeth E. Hoskins,et al.  Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro , 2010, Nature.

[188]  Alexander Meissner,et al.  Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. , 2010, Cell stem cell.

[189]  Erin L. Doyle,et al.  Targeting DNA Double-Strand Breaks with TAL Effector Nucleases , 2010, Genetics.

[190]  Deepak M. Gupta,et al.  A nonviral minicircle vector for deriving human iPS cells , 2010, Nature Methods.

[191]  M. Hasegawa,et al.  Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome , 2009, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[192]  R. Jaenisch,et al.  Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases , 2009, Nature Biotechnology.

[193]  A. Viale,et al.  Modeling Pathogenesis and Treatment of Familial Dysautonomia using Patient Specific iPSCs , 2009, Nature.

[194]  Hideyuki Okano,et al.  Variation in the safety of induced pluripotent stem cell lines , 2009, Nature Biotechnology.

[195]  Prashant Mali,et al.  Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. , 2009, Cell stem cell.

[196]  Robert Lanza,et al.  Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. , 2009, Cell stem cell.

[197]  R. Stewart,et al.  Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences , 2009, Science.

[198]  Wei Wang,et al.  piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells , 2009, Nature.

[199]  Kai Chen,et al.  Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation. , 2009, Cancer research.

[200]  James A. Thomson,et al.  Induced pluripotent stem cells from a spinal muscular atrophy patient , 2009, Nature.

[201]  F. Gage,et al.  Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. , 2008, Cell stem cell.

[202]  J. Utikal,et al.  Induced Pluripotent Stem Cells Generated Without Viral Integration , 2008, Science.

[203]  Donald C. Chang,et al.  Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. , 2008, RNA.

[204]  Rutger-Jan Swijnenburg,et al.  Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts , 2008, Proceedings of the National Academy of Sciences.

[205]  R. Hawley.  Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells? , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[206]  H. R. Lu,et al.  Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines , 2008, British journal of pharmacology.

[207]  J. Platt,et al.  Immunosuppression by Embryonic Stem Cells , 2008, Stem cells.

[208]  B. Thiers.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2008 .

[209]  Russell A. Wilke,et al.  Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges , 2008, Nature Reviews Drug Discovery.

[210]  Marius Wernig,et al.  Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin , 2007, Science.

[211]  Shulan Tian,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[212]  Luigi Naldini,et al.  Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery , 2007, Nature Biotechnology.

[213]  Hynek Wichterle,et al.  Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons , 2007, Nature Neuroscience.

[214]  Kevin Eggan,et al.  Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model , 2007, Nature Neuroscience.

[215]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[216]  Jeffrey C. Miller,et al.  Highly efficient endogenous human gene correction using designed zinc-finger nucleases , 2005, Nature.

[217]  Maya Schuldiner,et al.  Characterization of the expression of MHC proteins in human embryonic stem cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[218]  Fred H. Gage,et al.  Astroglia induce neurogenesis from adult neural stem cells , 2002, Nature.

[219]  Y. Nakajima,et al.  In Vitro Differentiation of Embryonic Stem Cells into Hepatocyte‐Like Cells Identified by Cellular Uptake of Indocyanine Green , 2002, Stem cells.

[220]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[221]  T. Munsat,et al.  International SMA Consortium Meeting (26–28 June 1992, Bonn, Germany) , 1992, Neuromuscular Disorders.

[222]  T. Munsat.  International SMA consortium meeting , 1992 .