Synthesis of a Hydrindenone in Rings C and D of YW3699

A hydrindenone in rings C and D of YW3699 was synthesized starting from (-)-isocarvone. The stereochemical requirement in this ring was successfully achieved by Eschenmoser–Claisen rearrangement followed by alkylation and the aldol reaction to afford the desired hydrindenone which can be used for further elaboration of YW3699.

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