of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis

The sensitivity of the fecal immunochemical test for occult human hemoglobin and its associated interval cancer rate are an important quality indicator of colorectal cancer screening programs. This study shows that, after two screening rounds, the Dutch colorectal cancer screening program has a high FIT-sensitivity with a low incidence of interval colorectal cancer. The probability of detecting interval colorectal cancer however increased as fecal hemoglobin concentrations rose below the cut-off value. The findings suggest there is potential for further optimizing colorectal cancer screening programs through the implementation of risk-stratified colorectal cancer screening based on prior fecal hemoglobin concentrations.