Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.

[1]  J. Mason,et al.  Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone. , 1984, Circulation research.

[2]  D H Singer,et al.  Amiodarone blocks calcium current in single guinea pig ventricular myocytes. , 1989, The Journal of pharmacology and experimental therapeutics.

[3]  D. Snyders,et al.  Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. , 1990, Circulation.

[4]  C. January,et al.  Triggered activity in the heart: cellular mechanisms of early after-depolarizations. , 1991, European heart journal.

[5]  D. Roden Early after-depolarizations and torsade de pointes: implications for the control of cardiac arrhythmias by prolonging repolarization. , 1993, European heart journal.

[6]  L. Hondeghem Computer Aided Development of Antiarrhythmic Agents with Class IIIa Properties , 1994, Journal of cardiovascular electrophysiology.

[7]  S. Hohnloser,et al.  Amiodarone-associated Proarrhythmic Effects: A Review with Special Reference to Torsade de Pointes Tachycardia , 1994, Annals of Internal Medicine.

[8]  S. Olsson,et al.  Monophasic Action Potentials: , 1994, Journal of cardiovascular electrophysiology.

[9]  C Antzelevitch,et al.  Cellular basis for the electrocardiographic J wave. , 1996, Circulation.

[10]  M. Sanguinetti,et al.  Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel , 1996, Nature.

[11]  A. Camm,et al.  Mortality in the Survival With ORal D-sotalol (SWORD) trial: why did patients die? , 1998, The American journal of cardiology.

[12]  S. Tang,et al.  QT prolongation and Torsades de Pointes associated with clarithromycin. , 1998, The American journal of medicine.

[13]  R. Woosley,et al.  Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence. , 1998, Journal of women's health.

[14]  S Nattel,et al.  The Molecular and Ionic Specificity of Antiarrhythmic Drug Actions , 1999, Journal of cardiovascular electrophysiology.

[15]  A. Garfinkel,et al.  Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation. , 1999, Circulation.

[16]  G. Hindricks,et al.  Clarithromycin-assoziierte Synkope als Erstmanifestation eines angeborenen langen QT-Syndroms? , 1999 .

[17]  P Smith,et al.  Concordance of the toxicity of pharmaceuticals in humans and in animals. , 2000, Regulatory toxicology and pharmacology : RTP.

[18]  J. Camm,et al.  Risk of torsades de pointes with non-cardiac drugs , 2000, BMJ : British Medical Journal.

[19]  A. Camm,et al.  The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. , 2000, Cardiovascular research.

[20]  T. Sacchi,et al.  QT Prolongation Associated with Azithromycin/Amiodarone Combination , 2001, Pacing and clinical electrophysiology : PACE.

[21]  G. Duker,et al.  Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic , 2001, Circulation.

[22]  T J Campbell,et al.  HERG K+ channels: friend and foe. , 2001, Trends in pharmacological sciences.

[23]  L. Hondeghem,et al.  Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia. , 2001, Cardiovascular research.

[24]  C. Nichols,et al.  Inward rectifiers in the heart: an update on I(K1). , 2001, Journal of molecular and cellular cardiology.

[25]  R. Kass,et al.  Molecular basis of the delayed rectifier current I(ks)in heart. , 2001, Journal of molecular and cellular cardiology.

[26]  Hua-rong Lu,et al.  Female Gender is a Risk Factor for Drug‐Induced Long QT and Cardiac Arrhythmias in an In Vivo Rabbit Model , 2001, Journal of cardiovascular electrophysiology.

[27]  Derek Leishman,et al.  Towards a drug concentration effect relationship for QT prolongation and torsades de pointes. , 2002, Current opinion in drug discovery & development.

[28]  G. Breithardt,et al.  Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes , 2002, Journal of Pharmacology and Experimental Therapeutics.

[29]  A. Camm,et al.  Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. , 2003, Cardiovascular research.

[30]  G. Gintant On a newly proposed in vitro proarrhythmia model. , 2003, Journal of cardiovascular pharmacology.

[31]  F. Marchlinski,et al.  Electrocardiographic Patterns of Superior Right Ventricular Outflow Tract Tachycardias: Distinguishing Septal and Free‐Wall Sites of Origin , 2003, Journal of cardiovascular electrophysiology.

[32]  P. Hoffmann,et al.  Blinded Test in Isolated Female Rabbit Heart Reliably Identifies Action Potential Duration Prolongation and Proarrhythmic Drugs: Importance of Triangulation, Reverse Use Dependence, and Instability , 2003, Journal of cardiovascular pharmacology.

[33]  Charles Antzelevitch,et al.  Assessing predictors of drug-induced torsade de pointes. , 2003, Trends in pharmacological sciences.

[34]  Hua-rong Lu,et al.  Detection of Proarrhythmia in the Female Rabbit Heart: , 2003, Journal of cardiovascular electrophysiology.

[35]  B. Katzung,et al.  Cardiac ventricular automaticity induced by current of injury , 1975, Pflügers Archiv European Journal of Physiology.

[36]  J. Mason,et al.  Amiodarone blocks inactivated cardiac sodium channels , 2004, Pflügers Archiv.

[37]  J. Valentin,et al.  Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes , 2004, Fundamental & clinical pharmacology.