Moonlighting proteins: old proteins learning new tricks.

Recently, several laboratories identifying proteins involved in the complex processes of replication, transcription and tumor suppression found that the 'new' protein they discovered had another, previously identified, function. A single protein with multiple functions might seem surprising, but there are actually many cases of proteins that 'moonlight', or have more than one role in an organism. As well as adding to the number and types of proteins that are known to moonlight, these new examples add to our understanding of the potential importance of moonlighting proteins.

[1]  A. Campbell,et al.  Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli. , 1981, Journal of molecular biology.

[2]  A. Paetau,et al.  Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer , 2002, Nature Genetics.

[3]  E S Husebye,et al.  Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. , 2001, American journal of human genetics.

[4]  P C Elwood,et al.  Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J D Beggs,et al.  Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. , 2000, Genetics.

[6]  N. Heintz,et al.  Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae. , 2002, Genetics.

[7]  I. Wool Extraribosomal functions of ribosomal proteins. , 1996, Trends in biochemical sciences.

[8]  Ulrich Müller,et al.  Mutations in SDHC cause autosomal dominant paraganglioma, type 3 , 2000, Nature Genetics.

[9]  Constance J Jeffery,et al.  Multifunctional proteins: examples of gene sharing , 2003, Annals of medicine.

[10]  J. Couchman,et al.  cDNA Cloning of the Basement Membrane Chondroitin Sulfate Proteoglycan Core Protein, Bamacan: A Five Domain Structure Including Coiled-Coil Motifs , 1997, The Journal of cell biology.

[11]  J D Beggs,et al.  Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. , 2000, RNA.

[12]  Thomas Kodadek,et al.  Recruitment of a 19S Proteasome Subcomplex to an Activated Promoter , 2002, Science.

[13]  A. Strunnikov,et al.  Characterization of the components of the putative mammalian sister chromatid cohesion complex. , 1999, Gene.

[14]  J. Piatigorsky Lens crystallins. Innovation associated with changes in gene regulation. , 1992, The Journal of biological chemistry.

[15]  Brian C. Rymond,et al.  Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition. , 1999, RNA.

[16]  M. Wabl,et al.  Mismatch repair co-opted by hypermutation. , 1998, Science.

[17]  H. Beinert,et al.  Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[18]  B. Devlin,et al.  Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. , 2000, Science.

[19]  G. Crabtree,et al.  Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Maloy,et al.  PutA protein, a membrane-associated flavin dehydrogenase, acts as a redox-dependent transcriptional regulator. , 1993, Proceedings of the National Academy of Sciences of the United States of America.