Optical imaging of brain activation in Gambian infants.

We used optical topography (OT) to investigate cognitive function in infants in rural Gambia. Images of changes in oxyhaemoglobin and deoxyhaemoglobin concentrations were reconstructed using a multispectral algorithm which uses the finite element method (FEM) to model the propagation of light through scattering tissue using the diffusion equation. High quality OT data enabled us to reconstruct images with robust representation of haemodynamic changes. OT is a feasible neuroimage technology for this resource-poor setting.

[1]  C. Elwell,et al.  Oscillations in Cerebral Haemodynamics in Patients with Falciparum Malaria , 2012, Advances in experimental medicine and biology.

[2]  Mark H Johnson,et al.  Cortical mapping of 3D optical topography in infants. , 2013, Advances in experimental medicine and biology.

[3]  Nick Everdell,et al.  Three-dimensional optical topography of brain activity in infants watching videos of human movement , 2012, Physics in medicine and biology.

[4]  Mark H. Johnson,et al.  Investigation of depth dependent changes in cerebral haemodynamics during face perception in infants , 2007, Physics in medicine and biology.

[5]  J. Hellwig,et al.  State of the World's Mothers: New Report From Save the Children , 2013 .

[6]  T. Charman,et al.  Reduced neural sensitivity to social stimuli in infants at risk for autism , 2013, Proceedings of the Royal Society B: Biological Sciences.

[7]  Clare E. Elwell,et al.  Cortical Activation to Action Perception is Associated with Action Production Abilities in Young Infants , 2013, Cerebral cortex.

[8]  Adam P. Gibson,et al.  A frequency multiplexed near infrared topography system for imaging functional activity in the brain , 2005 .

[9]  Clare E Elwell,et al.  Making light work: illuminating the future of biomedical optics , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[10]  Mark H. Johnson,et al.  The emergence of cerebral specialization for the human voice over the first months of life , 2012, Social neuroscience.

[11]  Simon R. Arridge,et al.  A method for three‐dimensional time‐resolved optical tomography , 2000 .

[12]  Mark H. Johnson,et al.  Early Specialization for Voice and Emotion Processing in the Infant Brain , 2011, Current Biology.

[13]  David A. Boas,et al.  Tetrahedral mesh generation from volumetric binary and grayscale images , 2009, 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro.