Numerical optimal control of a size-structured PDE model for metastatic cancer treatment.

In this paper, we propose a unified size-structured PDE model for the growth of metastatic tumors, which extends a well-known coupled ODE-PDE dynamical model developed and studied in the literature. A treatment model based on the proposed unified PDE model is investigated via optimal control theory, where its first-order necessary optimality system characterizing the optimal control is derived. We prove that the uniqueness of the optimal control depends on the chosen objective functional, and the optimal control is of bang-bang type when it is unique. For obtaining its efficient numerical solutions, a projection gradient descent algorithm based on the characteristic scheme is developed for solving the established optimal treatment model. Several numerical examples are provided to validate our mathematical analysis and numerical algorithm, and also illustrate the biologically interesting treatment outcomes of different models and control strategies. Our simple model reveals that: (i) only the total drug dosage matters if one just cares about the final treatment output; (ii) given the same total drug dosage, the optimal bang-bang treatment plan outperforms the others in the sense that it maximally reduces the total tumor sizes during the whole period of treatment, although their final tumor sizes are the same.