The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate.

The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.

[1]  V. Turk,et al.  Human cystatin, a new protein inhibitor of cysteine proteinases. , 1984, Biochemical and biophysical research communications.

[2]  A. Grubb,et al.  Human gamma-trace. Structure, function and clinical use of concentration measurements. , 1985, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[3]  A. Grubb,et al.  Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[4]  F. Karlsson,et al.  beta 2-Microglobulin in clinical medicine. , 1980, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[5]  M. Pagano,et al.  A heat stable low molecular weight inhibitor of lysosomal cysteine proteinases in human serum. , 1983, Biochemical and biophysical research communications.

[6]  R. Cohen,et al.  Microglobulinaemia in Renal Failure , 1968, Nature.

[7]  D. Heinegård,et al.  Determination of serum creatinine by a direct colorimetric method. , 1973, Clinica chimica acta; international journal of clinical chemistry.

[8]  D. S. Goodman.  Vitamin A and retinoids in health and disease. , 1984, The New England journal of medicine.

[9]  U. Ravnskov,et al.  Renal extraction of 2 -microglobulin. , 1972, Scandinavian journal of clinical and laboratory investigation.

[10]  F. R. Smith,et al.  The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. , 1971, The Journal of clinical investigation.

[11]  A. Fredriksson.  Renal handling of beta2-microglobulin in experimental renal disease. , 1975, Scandinavian journal of clinical and laboratory investigation.

[12]  A. Grubb,et al.  Quantitation of gamma-trace in human biological fluids: indications for production in the central nervous system. , 1979, Scandinavian journal of clinical and laboratory investigation.

[13]  H. Hotelling.  The Selection of Variates for Use in Prediction with Some Comments on the General Problem of Nuisance Parameters , 1940 .

[14]  R. Norrby,et al.  Estimation of glomerular filtration rate by serum creatinine and serum beta 2-microglobulin. , 1981, Nephron.

[15]  D. Mikhailidis,et al.  PLASMA CREATININE AND CREATININE CLEARANCE IN NUTRITIONAL OSTEOMALACIA , 1984, The Lancet.

[16]  P. Evrin,et al.  Serum 2 -microglobulin in renal disease. , 1973, Nephron.

[17]  F. Kiil,et al.  Influence of plasma potassium concentration on the capacity for sodium reabsorption in the diluting segment of the kidney. , 1980, Scandinavian journal of clinical and laboratory investigation.

[18]  A. Barrett,et al.  The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors , 1984 .

[19]  O. Nived,et al.  Is serum creatinine concentration a reliable index of renal function in rheumatic diseases? , 1983, British medical journal.

[20]  J. Helderman,et al.  Noninvasive monitoring of renal transplant function by analysis of beta2-microglobulin. , 1983, Kidney international.

[21]  P. A. Peterson,et al.  Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of beta-2-macroglobulin, albumin, and total protein. , 1969, The Journal of clinical investigation.

[22]  P. Attman,et al.  Renal hemodynamics and limitations of creatinine clearance in determining filtration rate in glomerular disease. , 1971, Scandinavian journal of urology and nephrology.

[23]  P. A. Peterson,et al.  Metabolism of the Vitamin A Transporting Protein Complex , 1973, Scandinavian journal of clinical and laboratory investigation.

[24]  J. Bröchner-Mortensen.  A simple method for the determination of glomerular filtration rate. , 1972, Scandinavian journal of clinical and laboratory investigation.

[25]  N. S. Heilskov,et al.  Pronounced increase in serum creatinine concentration after eating cooked meat. , 1979, British medical journal.

[26]  P. Evrin,et al.  The serum levels and urinary excretion of 2 -microglobulin in apparently healthy subjects. , 1972, Scandinavian journal of clinical and laboratory investigation.

[27]  L. Truedsson,et al.  Serum level of complement factor D in systemic lupus erythematosus--an indicator of glomerular filtration rate. , 2009, Acta medica Scandinavica.