BRAF (V600E) mutation in isthmic malignant thyroid nodules

Thyroid cancers occur in approximately 2-5% of all nodules, with an incidence of about 3.8% of all new cancer diagnosis in 2014. Differentiated thyroid cancer (DTC) is the most common thyroid cancer type. Incidence has been increasing in the last few decades, mainly due to incidental detection of small, low-risk, cancers (i.e. ≤ 2 cm) by neck ultrasound. Accordingly, DTC related mortality has not increased and, to date, it is reported at about 0.5 cases per 100.000 persons. This article is protected by copyright. All rights reserved.