Induction of apoptosis in mammary gland by a pure anti-estrogen ICI 182780

[1]  J. Reed,et al.  Bcl-2 Gene Family and Related Proteins in Mammary Gland Involution and Breast Cancer , 1999, Journal of Mammary Gland Biology and Neoplasia.

[2]  J. Hickman,et al.  Apoptosis induced by anticancer drugs , 1992, Cancer and Metastasis Reviews.

[3]  M. Parker.  Action of “pure” antiestrogens in inhibiting estrogen receptor action , 2004, Breast Cancer Research and Treatment.

[4]  S. Hilsenbeck,et al.  The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth , 2004, Cancer Chemotherapy and Pharmacology.

[5]  R. Baxter,et al.  Growth Inhibition by Insulin-like Growth Factor-binding Protein-3 in T47D Breast Cancer Cells Requires Transforming Growth Factor-β (TGF-β) and the Type II TGF-β Receptor* , 2000, The Journal of Biological Chemistry.

[6]  M. King,et al.  Insulin-like Growth Factor-binding Protein-3 Modulates Expression of Bax and Bcl-2 and Potentiates p53-independent Radiation-induced Apoptosis in Human Breast Cancer Cells* , 2000, The Journal of Biological Chemistry.

[7]  R. Baserga.  The contradictions of the insulin-like growth factor 1 receptor , 2000, Oncogene.

[8]  R. Baxter,et al.  Growth inhibition by insulin-like growth factor-binding protein-3 in T47D breast cancer cells requires transforming growth factor-beta (TGF-beta ) and the type II TGF-beta receptor. , 2000, The Journal of biological chemistry.

[9]  G. Christofori,et al.  Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells. , 1998, Cancer research.

[10]  S. Lehar,et al.  Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells. , 1998, Cancer research.

[11]  H. Huynh,et al.  Castration-Induced Apoptosis in the Rat Ventral Prostate Is Associated with Increased Expression of Genes Encoding Insulin-Like Growth Factor Binding Proteins 2, 3, 4 and 5. , 1998, Endocrinology.

[12]  H. Huynh,et al.  Castration-induced apoptosis in the rat ventral prostate is associated with increased expression of genes encoding insulin-like growth factor binding proteins 2,3,4 and 5. , 1998, Endocrinology.

[13]  Y. Harima,et al.  Bax and Bcl-2 expressions predict response to radiotherapy in human cervical cancer , 1998, Journal of Cancer Research and Clinical Oncology.

[14]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[15]  H. Huynh,et al.  Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells. , 1997, Biochemical and biophysical research communications.

[16]  D. Leroith,et al.  Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product. , 1997, Endocrinology.

[17]  D. Leroith,et al.  Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product. , 1997, Endocrinology.

[18]  V. Dixit,et al.  Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins* , 1996, The Journal of Biological Chemistry.

[19]  H. Huynh,et al.  Regulation of insulin-like growth factor I receptor expression by the pure antiestrogen ICI 182780. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[20]  Elizabeth Yang,et al.  Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL , 1996, Cell.

[21]  T Takahashi,et al.  Overexpression of bax sensitizes human breast cancer MCF‐7 cells to radiation‐induced apoptosis , 1996, International journal of cancer.

[22]  J. Pink,et al.  Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. , 1996, Cancer research.

[23]  M. Mandal,et al.  Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[24]  M. Pollak,et al.  Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells (*) , 1996, The Journal of Biological Chemistry.

[25]  Z. Oltvai,et al.  Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Clarke,et al.  Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis. , 1995, Cancer research.

[27]  Thomas T. Y. Wang,et al.  Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. , 1995, Cancer research.

[28]  C. Larsson,et al.  Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor. , 1995, Cancer research.

[29]  J. Lotem,et al.  Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[30]  S. Hilsenbeck,et al.  Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. , 1995, Journal of the National Cancer Institute.

[31]  H. Steller.  Mechanisms and genes of cellular suicide , 1995, Science.

[32]  C. Thompson,et al.  Apoptosis in the pathogenesis and treatment of disease , 1995, Science.

[33]  E. Gelmann,et al.  Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells. , 1995, Cancer research.

[34]  A. Howell,et al.  Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer , 1995, The Lancet.

[35]  M. Caligiuri,et al.  The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[36]  H. Huynh,et al.  Uterotrophic actions of estradiol and tamoxifen are associated with inhibition of uterine insulin-like growth factor binding protein 3 gene expression. , 1994, Cancer research.

[37]  R. Henderson,et al.  Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. , 1994, Science.

[38]  A. Howell,et al.  Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer. , 1994, Cancer research.

[39]  M. Parker,et al.  The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. , 1993, Journal of cell science.

[40]  R. Sutherland,et al.  Circumvention of tamoxifen resistance by the pure anti‐estrogen ICI 182, 780 , 1993, International journal of cancer.

[41]  A. Wärri,et al.  Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro. , 1993, Journal of the National Cancer Institute.

[42]  S. Korsmeyer,et al.  Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death , 1993, Cell.

[43]  C. Thompson,et al.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death , 1993, Cell.

[44]  J. Hickman,et al.  bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. , 1993, Cancer research.

[45]  D. Carson,et al.  Apoptosis and disease , 1993, The Lancet.

[46]  S. Korsmeyer.  Bcl-2 initiates a new category of oncogenes: regulators of cell death. , 1992, Blood.

[47]  Anthony Howell,et al.  Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group. , 1992 .

[48]  A. D. Schryver,et al.  Systemic treatment of early breast-cancer by hormonal, cytotoxic, or immune therapy: 133 randomized trials involving 31000 recurrences and 24000 deaths among 75000 women: 1 , 1992 .

[49]  S. Korsmeyer,et al.  BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[50]  A. Wakeling,et al.  A potent specific pure antiestrogen with clinical potential. , 1991, Cancer research.

[51]  R. Schreiber,et al.  Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death , 1990, Nature.

[52]  S. Korsmeyer,et al.  Alternative promoters and exons, somatic mutation and deregulation of the Bcl‐2‐Ig fusion gene in lymphoma. , 1988, The EMBO journal.

[53]  H. Rochefort,et al.  Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens. , 1987, Biochemical and biophysical research communications.

[54]  H. Rochefort,et al.  Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells. , 1987, Cancer research.