The UCLA population studies of chronic obstructive respiratory disease: XI. Impact of air pollution and smoking on annual change in forced expiratory volume in one second.

We assessed the relative impact of residential exposure to community air pollution and habitual cigarette smoking on lung function by comparing the annualized rate of change in forced expiratory volume in 1 s (FEV1) in current, former, and never-smokers 25 to 59 yr of age residing in three demographically similar areas of the Southern California air basin who had been chronically exposed to (1) moderate levels of photochemical oxidants and very low levels of other pollutants (Lancaster); (2) very high levels of photochemical oxidants, sulfates, and particulate matter (Glendora); and (3) high levels of sulfates, oxides of nitrogen, and probably hydrocarbons (Long Beach), together with moderate levels of sulfur dioxide. Of the 621 to 763 nonsmokers, 317 to 479 former smokers and 472 to 691 continuing smokers residing in the three areas who were studied initially, 53 to 64, 49 to 59, and 43 to 54%, respectively, were retested. For male residents, area of residence and smoking category each had highly significant effects on FEV1 decline (two-way ANCOVA; p < 0.001) without significant interaction (p > 0.4). After adjustment for baseline FEV1, age, height, and a history of allergy, the mean decline in FEV1 attributable to living in Long Beach compared with living in Lancaster was 23.6 ml/yr, which was 71% of the rate of decline in FEV1 (33.3 ml/yr), attributable to smoking > 1 pack of cigarettes per day. For female residents, a significant interaction was noted between area and smoking (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

[1]  P. Quanjer,et al.  Decreases in VC and FEV1 with time: indicators for effects of smoking and air pollution. , 1981, Bulletin europeen de physiopathologie respiratoire.

[2]  R. Peto,et al.  The natural history of chronic airflow obstruction. , 1977, British medical journal.

[3]  B. Ferris,et al.  Chronic nonspecific respiratory disease in Berlin, New Hampshire, 1961 to 1967. A follow-up study. , 2015, The American review of respiratory disease.

[4]  N. Zamel,et al.  The respiratory effects of regular cigarette smoking in women. A five-year prospective study. , 1980, Chest.

[5]  E. Huhti,et al.  A 10-year follow-up study of respiratory symptoms and ventilatory function in a middle-aged rural population. , 1980 .

[6]  F. Massey,et al.  The UCLA population studies of chronic obstructive respiratory disease. I. Methodology and comparison of lung function in areas of high and low pollution. , 1979, American journal of epidemiology.

[7]  M. Lebowitz,et al.  Changes in the normal maximal expiratory flow-volume curve with growth and aging. , 1983, The American review of respiratory disease.

[8]  B. Ferris,et al.  Environmental epidemiology. IV. Chronic respiratory disease in an industrial town: a nine-year follow-up study. Preliminary report. , 1968, American journal of public health and the nation's health.

[9]  J. Lellouch,et al.  Twelve years spirometric changes among Paris area workers. , 1979, International journal of epidemiology.

[10]  M. Lebowitz,et al.  Longitudinal changes in forced expiratory volume in one second in adults. Effects of smoking and smoking cessation. , 1987, The American review of respiratory disease.

[11]  P. Costa,et al.  Cigarette smoking, aging, and decline in pulmonary function: A longitudinal study. , 1980, Archives of environmental health.

[12]  R. Bossé,et al.  Longitudinal effect of age and smoking cessation on pulmonary function. , 2015, The American review of respiratory disease.

[13]  M. Wysocki,et al.  Factors associated with the change in ventilatory function and the development of chronic obstructive pulmonary disease in a 13-year follow-up of the Cracow Study. Risk of chronic obstructive pulmonary disease. , 1986, The American review of respiratory disease.

[14]  R. Detels,et al.  The UCLA population studies of chronic obstructive respiratory disease. II. Determination of reliability and estimation of sensitivity and specificity. , 1979, Environmental research.

[15]  B. Rosner,et al.  The effect of occupational exposure on pulmonary function: a longitudinal evaluation of fire fighters and nonfire fighters. , 1982, The American review of respiratory disease.

[16]  T. Beaty,et al.  Risk factors associated with longitudinal change in pulmonary function. , 2015, The American review of respiratory disease.

[17]  D H Wegman,et al.  The UCLA population studies of CORD: X. A cohort study of changes in respiratory function associated with chronic exposure to SOx, NOx, and hydrocarbons. , 1991, American journal of public health.

[18]  A. Woolcock,et al.  Decline of lung function and development of chronic airflow limitation: a longitudinal study of non-smokers and smokers in Busselton, Western Australia. , 1990, Thorax.

[19]  C. Fletcher.  The Natural history of chronic bronchitis and emphysema: An eight-year study of early chronic obstructive lung disease in working men in London , 1976 .

[20]  F. Massey,et al.  The UCLA population studies of chronic obstructive respiratory disease. 9. Lung function changes associated with chronic exposure to photochemical oxidants; a cohort study among never-smokers. , 1987, Chest.

[21]  P. Schnohr,et al.  Effects of smoking and changes in smoking habits on the decline of FEV1. , 1989, The European respiratory journal.

[22]  F. Massey,et al.  The UCLA population studies of chronic obstructive respiratory disease. VI. Relationship of physiologic factors to rate of change in forced expiratory volume in one second and forced vital capacity. , 1984, The American review of respiratory disease.

[23]  J. Bloom,et al.  The course and prognosis of different forms of chronic airways obstruction in a sample from the general population. , 1987, The New England journal of medicine.

[24]  F. Massey,et al.  The UCLA population studies of chronic obstructive respiratory disease. IV. Respiratory effect of long-term exposure to photochemical oxidants, nitrogen dioxide, and sulfates on current and never smokers. , 1981, The American review of respiratory disease.

[25]  E. Schachter,et al.  A longitudinal study of respiratory health in a rural community. , 1982, The American review of respiratory disease.