Feline corneal sequestra: outcome of corneoconjunctival transposition in 97 cats (109 eyes)

Case series summary A retrospective study was undertaken to review outcomes of keratectomy and corneoconjunctival transposition in cats with superficial and deep corneal sequestra. Information including pertinent history, signalment, ophthalmological findings and postoperative outcome was collected from medical records. Follow-up was obtained by clinical examination, contact with the referring veterinarians and review of medical records or telephone contact with owners. Ninety-seven cats (109 eyes) were included from 2005–2015. The most commonly affected breeds included Persian, Burmese and Himalayan. The mean age at the time of surgery was 6.8 years (median 6.5 years; range 8.0 months–18.0 years). A corneal sequestrum in the contralateral eye was diagnosed in 28 cats (28.9%). Recurrent corneal sequestration was diagnosed in eight cats (nine eyes), with recurrence occurring a mean of 703 days after surgery (range 29–1750 days). Age, sex, breed, depth of sequestration and concurrent ocular disease in the contralateral eye were compared between cats with and without recurrence, with no risk factors for recurrence identified. Relevance and novel information Excellent surgical outcomes have previously been described in a series of 17 cats with superficial and mid-stromal corneal sequestra. This paper adds further information to the literature by describing a larger series of cats, with corneal sequestra affecting the full range of corneal thickness, and good long-term postoperative outcomes.

[1]  P. Kass,et al.  Reference values, intertest correlations, and test-retest repeatability of selected tear film tests in healthy cats. , 2015, Journal of the American Veterinary Medical Association.

[2]  P. Isard,et al.  Use of bovine pericardium (Tutopatch®) graft for surgical repair of deep melting corneal ulcers in dogs and corneal sequestra in cats. , 2014, Veterinary ophthalmology.

[3]  F. Goulle Use of porcine small intestinal submucosa for corneal reconstruction in dogs and cats: 106 cases. , 2012, The Journal of small animal practice.

[4]  C. Mortellaro,et al.  Amniotic membrane transplantation for the treatment of feline corneal sequestrum: pilot study. , 2010, Veterinary ophthalmology.

[5]  C. Reilly,et al.  Effects of feline herpesvirus type 1 on tear film break-up time, Schirmer tear test results, and conjunctival goblet cell density in experimentally infected cats. , 2009, American journal of veterinary research.

[6]  W. Townsend,et al.  Heterologous penetrating keratoplasty for treatment of a corneal sequestrum in a cat. , 2008, Veterinary ophthalmology.

[7]  B. Grahn,et al.  Qualitative tear film and conjunctival goblet cell assessment of cats with corneal sequestra. , 2005, Veterinary ophthalmology.

[8]  H. Featherstone,et al.  Feline corneal sequestra: a review of 64 cases (80 eyes) from 1993 to 2000. , 2004, Veterinary ophthalmology.

[9]  W. Townsend,et al.  Development of a reverse transcriptase-polymerase chain reaction assay to detect feline herpesvirus-1 latency-associated transcripts in the trigeminal ganglia and corneas of cats that did not have clinical signs of ocular disease. , 2004, American journal of veterinary research.

[10]  D. Brooks,et al.  Corneoconjunctival transposition for the treatment of feline corneal sequestra: a retrospective study of 17 cases (1990-1998). , 2001, Veterinary ophthalmology.

[11]  N. L. La Croix,et al.  Nonhealing corneal ulcers in cats: 29 cases (1991-1999). , 2001, Journal of the American Veterinary Medical Association.

[12]  H. Dua The conjunctiva in corneal epithelial wound healing , 1998, The British journal of ophthalmology.

[13]  C. P. Moore,et al.  Detection of feline herpesvirus 1 DNA in corneas of cats with eosinophilic keratitis or corneal sequestration. , 1998, American journal of veterinary research.

[14]  D. Wilkie,et al.  Surgery of the cornea. , 1997, The Veterinary clinics of North America. Small animal practice.

[15]  C. Greene,et al.  Use of nested polymerase chain reaction to identify feline herpesvirus in ocular tissue from clinically normal cats and cats with corneal sequestra or conjunctivitis. , 1997, American journal of veterinary research.

[16]  B. Sherry,et al.  High sensitivity polymerase chain reaction assay for active and latent feline herpesvirus- infections in domestic cats , 1997, Veterinary Record.

[17]  M. Nasisse Feline herpesvirus ocular disease. , 1990, The Veterinary clinics of North America. Small animal practice.

[18]  F. Startup Corneal necrosis and sequestration in the cat: a review and record of 100 cases , 1988 .

[19]  G. D. Vawer Corneal mummification in colourpoint cats , 1981, Veterinary Record.

[20]  E. Souri The feline corneal nigrum. , 1975, Veterinary medicine, small animal clinician : VM, SAC.