Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort

Department of Genetics, CB#7264, Lineberger Comprehensive Cancer Center, Rm 11-109, University of North Carolina, Chapel Hill, North Carolina 27599, USA Laboratory of Population Genetics, DCEG/NCI/NIH, Bldg 41, Rm 702, 41 Library Drive, Bethesda, Maryland 20892, USA Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, 858 Madison Avenue, Rm 101A, Memphis, Tennessee 38163, USA

[1]  V. C. Bode.  Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17. , 1984, Genetics.

[2]  D. Simon,et al.  A high-resolution microsatellite map of the mouse genome. , 1998, Genome research.

[3]  Hans Lehrach,et al.  Functional Annotation of Mouse Genome Sequences , 2001, Science.

[4]  Klaus Schughart,et al.  Genome-wide, large-scale production of mutant mice by ENU mutagenesis , 2000, Nature Genetics.

[5]  J. Witte,et al.  Genetic dissection of complex traits. , 1994, Nature genetics.

[6]  E. Fisher,et al.  Mighty mice , 2000, Nature.

[7]  M. Festing.  Recombinant Inbred Strains , 1979 .

[8]  E. Lander,et al.  Analysing complex genetic traits with chromosome substitution strains , 2000, Nature Genetics.

[9]  Janan T. Eppig,et al.  Genealogies of mouse inbred strains , 2000, Nature Genetics.

[10]  P. Hunsicker,et al.  Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[11]  E. Fisher,et al.  Mighty mice - Clarence Little's brainwave gave biomedical researchers their best friend. , 2000 .

[12]  D. Bailey.  RECOMBINANT‐INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES , 1971, Transplantation.

[13]  David W. Melton,et al.  Targetted correction of a mutant HPRT gene in mouse embryonic stem cells , 1987, Nature.

[14]  Joseph H. Nadeau,et al.  The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs , 2000, Nature Genetics.

[15]  Steve D. M. Brown,et al.  A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse , 2000, Nature Genetics.

[16]  J. Nap,et al.  Genetical genomics : the added value from segregation , 2001 .

[17]  I. Kalcheva,et al.  Genome-tagged mice (GTM): two sets of genome-wide congenic strains. , 2001, Genomics.

[18]  F H Ruddle,et al.  Genetic transformation of mouse embryos by microinjection of purified DNA. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[19]  J. Witte,et al.  Genetic dissection of complex traits , 1996, Nature Genetics.

[20]  Janan T. Eppig,et al.  A mouse phenome project , 2000, Mammalian Genome.

[21]  T. Magnuson,et al.  Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells , 2000, Nature Genetics.

[22]  M. Capecchi,et al.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells , 1987, Cell.

[23]  P. L. Broadhurst.  Recombinant Inbred Strains , 1978 .

[24]  Francis S. Collins,et al.  Positional cloning moves from perditional to traditional , 1995, Nature Genetics.