Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells.

[1]  J. Kos,et al.  Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X , 2008, Journal of leukocyte biology.

[2]  Janko Kos,et al.  The role of cathepsin X in the migration and invasiveness of T lymphocytes , 2008, Journal of Cell Science.

[3]  J. Kos,et al.  Cysteine protease cathepsin X modulates immune response via activation of β2 integrins , 2008, Immunology.

[4]  E. Plow,et al.  Histone H2B as a functionally important plasminogen receptor on macrophages. , 2007, Blood.

[5]  H. Luebbert,et al.  Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells , 2007, Neurobiology of Aging.

[6]  C. Stichel,et al.  Differential expression of cathepsin X in aging and pathological central nervous system of mice , 2007, Experimental Neurology.

[7]  S. Zahler,et al.  RGD-dependent Binding of Procathepsin X to Integrin αvβ3 Mediates Cell-adhesive Properties* , 2006, Journal of Biological Chemistry.

[8]  J. Kos,et al.  Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells. , 2006, Experimental cell research.

[9]  J. Kos,et al.  Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. , 2005, Experimental cell research.

[10]  L. Juliano,et al.  Cathepsin X binds to cell surface heparan sulfate proteoglycans. , 2005, Archives of biochemistry and biophysics.

[11]  E. Purisima,et al.  Carboxy-monopeptidase substrate specificity of human cathepsin X. , 2005, Biochemical and biophysical research communications.

[12]  H. Nagasawa,et al.  Localization of enolase in synaptic plasma membrane as an αγ heterodimer in rat brain , 2004, Neuroscience Research.

[13]  Bonnie F. Sloane,et al.  Pericellular cathepsin B and malignant progression , 2003, Cancer and Metastasis Reviews.

[14]  Jordi Félez,et al.  Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against α‐Enolase , 2003, American journal of hematology.

[15]  F. Zhong,et al.  Neuritogenesis and the Nerve Growth Factor-induced Differentiation of PC-12 Cells Requires Annexin II-mediated Plasmin Generation* , 2001, The Journal of Biological Chemistry.

[16]  S. L. Gonias,et al.  Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells. , 2001, Frontiers in bioscience : a journal and virtual library.

[17]  E. Purisima,et al.  Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities. , 2001, Biochemistry.

[18]  D. Turk,et al.  Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase. , 2000, European journal of biochemistry.

[19]  D. Turk,et al.  Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. , 2000, Structure.

[20]  E. Purisima,et al.  Human cathepsin X: A cysteine protease with unique carboxypeptidase activity. , 1999, Biochemistry.

[21]  L. Devi,et al.  Inflammatory Mediators Regulate Cathepsin S in Macrophages and Microglia: A Role in Attenuating Heparan Sulfate Interactions , 1999, Molecular medicine.

[22]  P. Ganz,et al.  ENDOTHELIAL CELL SURFACE ACTIN SERVES AS A BINDING SITE FOR PLASMINOGEN, TISSUE PLASMINOGEN ACTIVATOR AND LIPOPROTEIN(a) , 1996, British journal of haematology.

[23]  N. Takei,et al.  Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain , 1995, Neuroscience Research.

[24]  Kanefusa Kato,et al.  Plasminogen Binds Specifically to α‐Enolase on Rat Neuronal Plasma Membrane , 1994 .

[25]  K. Hajjar,et al.  An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. , 1994, The Journal of biological chemistry.

[26]  Y. Mizuno,et al.  Synthetic peptide corresponding to 30 amino acids of the C-terminal of neuron-specific enolase promotes survival of neocortical neurons in culture. , 1994, Biochemical and biophysical research communications.

[27]  H. Saito,et al.  Microglia-derived plasminogen enhances neurite outgrowth from explant cultures of rat brain , 1993, International Journal of Developmental Neuroscience.

[28]  Y. Saito,et al.  Isolation and characterization of possible target proteins responsible for neurite outgrowth induced by a tripeptide aldehyde in PC12H cells. , 1992, Biochemical and biophysical research communications.

[29]  L. Greene,et al.  Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity , 1991, The Journal of cell biology.

[30]  Y. Saito,et al.  The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells. , 1989, Journal of biochemistry.

[31]  Yumiko Saito,et al.  Enhancement of neurite outgrowth in PC12h cells by a protease inhibitor , 1988, Neuroscience Letters.

[32]  E. Ginns,et al.  Localization of neuron-specific enolase (NSE) mRNA in human brain , 1987, Neuroscience Letters.

[33]  E. Johnson,et al.  Experimental autoimmune model of nerve growth factor deprivation: effects on developing peripheral sympathetic and sensory neurons. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[34]  L. Greene,et al.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[35]  S. Zahler,et al.  RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties. , 2006, The Journal of biological chemistry.

[36]  D. Turk,et al.  Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L , 2005, Biological chemistry.

[37]  服部 達哉.  Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain , 1995 .

[38]  Y. Saito,et al.  Possible involvement of a novel protease in neurite outgrowth of PC12 cells. , 1990, Neuroscience research. Supplement : the official journal of the Japan Neuroscience Society.