Prevalence of periodontal diseases in a multicenter cohort of perinatally HIV‐infected and HIV‐exposed and uninfected youth

AIMS To compare the prevalence and severity of periodontal diseases between 180 perinatally HIV-infected (PHIV) and 118 perinatally HIV-exposed and uninfected (PHEU) youth in a cross-sectional study conducted at 11 clinical sites in the United States and Puerto Rico from the Adolescent Master Protocol study of the Pediatric HIV/AIDS cohort study (PHACS) network. METHODS Several analyses were conducted, employing the current CDC/AAP classification for periodontitis and incorporating a definition of gingivitis based on a bleeding on probing (BOP) threshold, and analyses based on more detailed whole-mouth, intra-oral regionally, site-based and tooth-based criteria of BOP, plaque levels, pockets depths and clinical attachment levels. RESULTS After adjusting for plaque control habits and behavioural and sociodemographic factors, there were no significant differences in periodontal diseases between the PHIV and PHEU youth using any of these criteria. For PHIV youth, there was no significant association between parameters of periodontal disease and current HIV status. CONCLUSIONS Although no significant differences in periodontal parameters were noted between the PHIV and PHEU youth, the influence of antiretroviral therapy merits further exploration in this cohort in a longitudinal study.

Victor Badner | Ram Yogev | Vivian Olivera | Kenneth Markowitz | A. Moscicki | C. Shiboski | E. Barr | T. Yao | M. Purswani | R. Yogev | M. Ryder | V. Badner | R. Gandhi | A. Vorachek | W. Shearer | E. McFarland | M. Paul | S. Burchett | K. Malee | Emily Barr | Ana Puga | K. Markowitz | Sandra Burchett | A. Wiznia | A. Puga | J. Russell | Mitzie Grant | Doyle Patton | Mark I. Ryder | Tzy‐Jyun Yao | Jonathan S. Russell | Anna‐Barbara Moscicki | Caroline H. Shiboski | Ester Yang | William Shearer | Mary Paul | Norma Cooper | Lynette Harris | Karen Kemp‐Posterman | Selene Wun | Murli Purswani | Mahboobullah Baig | Anna Cintron | Jennifer Zeni | Sandra Navarro | Deyana Leon | Man Wai Ng | Nancy Karthas | Betsy Kammerer | Ray Jurado | Johnny Kuttab | Ashlee Vorachek | Margaret Ann Sanders | Kathleen Malee | Scott Hunter | Ronald Garreett | Andrew Wiznia | Marlene Burey | Molly Nozyce | Susan Chialastri | Janet Chen | Latreca Ivey | Maria Garcia Bulkley | Ramon Gonzalez | Midnela Acevedo‐Flores | Heida Rios | Janice Townsend | Margarita Silio | Medea Jones | Patricia Sirois | Roopa Gandhi | Elizabeth McFarland | Robin McEvoy | Arry Dieudonne | Linda Bettica | Susan Adubato | P. Sirois | M. Grant | B. Kammerer | M. Silió | M. Nozyce | E. Yang | Scott Hunter | N. Cooper | Mahboobullah Baig | Anna Cintron | S. Navarro | N. Karthas | M. Burey | A. Dieudonne | L. Bettica | S. Adubato | Midnela Acevedo‐Flores | Heida Rios | Vivian Olivera | Medea Jones | S. Chialastri | R. McEvoy | R. Jurado | Janet S. Chen | L. Harris | Doyle E. Patton | Karen Kemp‐Posterman | S. Wun | Jennifer Zeni | D. Leon | Jonathan Kuttab | Ronald Garreett | L. Ivey | Ramón González | J. Townsend | Man Wai Ng | Margaret Ann Sanders

[1]  M. Glick,et al.  Necrotizing ulcerative periodontitis: a marker for immune deterioration and a predictor for the diagnosis of AIDS. , 1994, Journal of periodontology.

[2]  Prevalence of oral manifestations of HIV infection in Rio De Janeiro, Brazil from 1988 to 2004. , 2007, AIDS patient care and STDs.

[3]  J. Beck,et al.  Rethinking periodontal inflammation. , 2008, Journal of periodontology.

[4]  P. Eke,et al.  Update of the case definitions for population-based surveillance of periodontitis. , 2012, Journal of periodontology.

[5]  P. Eke,et al.  Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012. , 2015, Journal of periodontology.

[6]  J. Reddy.  Control of HIV/AIDS and AIDS-related conditions in Africa with special reference to periodontal diseases. , 2007, Journal of the International Academy of Periodontology.

[7]  L. Patton,et al.  Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy. , 2000, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[8]  L. Gonçalves,et al.  Clinical and microbiological profiles of human immunodeficiency virus (HIV)-seropositive Brazilians undergoing highly active antiretroviral therapy and HIV-seronegative Brazilians with chronic periodontitis. , 2007, Journal of periodontology.

[9]  M. Katz,et al.  Prevalence of HIV-associated periodontitis and gingivitis in HIV-infected patients attending an AIDS clinic. , 1992, Journal of acquired immune deficiency syndromes.

[10]  V. Baelum,et al.  Classifying periodontitis among adolescents: implications for epidemiological research. , 2003, Community dentistry and oral epidemiology.

[11]  L. Mofenson,et al.  Antiretroviral Treatment of US Children With Perinatally Acquired HIV Infection: Temporal Changes in Therapy Between 1991 and 2009 and Predictors of Immunologic and Virologic Outcomes , 2011, Journal of acquired immune deficiency syndromes.

[12]  C. Williams,et al.  HIV-associated periodontitis complicated by necrotizing stomatitis. , 1990, Oral surgery, oral medicine, and oral pathology.

[13]  Z. Shey,et al.  Oral soft tissue manifestations and CD4 lymphocyte counts in HIV-infected children. , 1996, Pediatric dentistry.

[14]  J. Albandar,et al.  Global epidemiology of periodontal diseases in children and young persons. , 2002, Periodontology 2000.

[15]  A. Tappuni,et al.  The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. , 2001, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[16]  T. Eigner,et al.  Rapidly progressive periodontal disease associated with HIV infection: report of case. , 1989, Journal of the American Dental Association.

[17]  Castro Gf,et al.  Oral manifestations related to immunosuppression degree in HIV-positive children. , 2001 .

[18]  M. Correnti,et al.  Periodontal conditions and distribution of Prevotella intermedia, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in HIV-infected patients undergoing anti-retroviral therapy and in an HIV-seronegative group of the Venezuelan population. , 2008, Acta odontologica latinoamericana : AOL.

[19]  G. T. Jones,et al.  Classification and diagnostic criteria for oral lesions in HIV infection , 1994 .

[20]  H. Löe,et al.  PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY. , 1963, Acta odontologica Scandinavica.

[21]  J. Pogoda,et al.  The effect of HAART on salivary microbiota in the Women's Interagency HIV Study (WIHS). , 2005, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[22]  W. M. Jenkins,et al.  Epidemiology of periodontal disease in children and adolescents. , 2001, Periodontology 2000.

[23]  M. Grassi,et al.  Diagnosis and management of HIV-associated periodontal lesions. , 1989, Journal of the American Dental Association.

[24]  Anna-Barbara Moscicki,et al.  The Burden of Oral Disease among Perinatally HIV-Infected and HIV-Exposed Uninfected Youth , 2016, PloS one.

[25]  A. Ritter,et al.  Periodontal Disease , 2005 .

[26]  H. Löe,et al.  PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. , 1964, Acta odontologica Scandinavica.

[27]  I. P. D. de Souza,et al.  Oral manifestations related to immunosuppression degree in HIV-positive children. , 2001, Brazilian dental journal.

[28]  Emily S. Charlson,et al.  Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals. , 2015, American journal of respiratory and critical care medicine.

[29]  T. Derouen,et al.  A Covariance Estimator for GEE with Improved Small‐Sample Properties , 2001, Biometrics.

[30]  T. Derouen,et al.  Concise Review: Statistical Issues in Periodontal Research , 1995, Journal of dental research.

[31]  M. G. Magalhães,et al.  Oral manifestations of HIV positive children. , 2001, The Journal of clinical pediatric dentistry.

[32]  Davoodi Poorandokht,et al.  Oral Manifestations Related To CD4 Lymphocyte Count in HIV-Positive Patients , 2010 .

[33]  J. Burmeister,et al.  Periodontal health in 200 HIV-positive patients. , 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[34]  C. Kozinetz,et al.  Longitudinal Study of the Prevalence and Prognostic Implications of Oral Manifestations in Romanian Children Infected with Human Immunodeficiency Virus Type 1 , 2005, The Pediatric infectious disease journal.

[35]  M. Lederman,et al.  A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults. , 2011, AIDS research and human retroviruses.

[36]  M. Ryder,et al.  Periodontal disease in HIV/AIDS. , 2012, Periodontology 2000.

[37]  V. Ramírez-Amador,et al.  The Changing Clinical Spectrum of Human Immunodeficiency Virus (HIV)-Related Oral Lesions in 1,000 Consecutive Patients: A 12-Year Study in a Referral Center in Mexico , 2003, Medicine.