R‐Ras promotes tumor growth of cervical epithelial cells

R‐Ras is 55% identical to H‐Ras. However, these two oncogenes seem to have different tumor‐transforming potential. R‐Ras induced cell transformation in fibroblasts but not in other cell types. R‐Ras also reportedly induces a more invasive phenotype in breast epithelial cells through integrin activation. The authors studied the mechanisms whereby R‐Ras induces a malignant phenotype.

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