Lymphomas resembling lymphoid leukosis in chickens inoculated with reticuloendotheliosis virus

Chickens inoculated as embryos or at hatching with the chick syncytial strain of reticuloendo‐theliosis virus developed a high incidence of lymph‐oid neoplasms between the 17th and 43rd weeks of age, involving principally the liver and bursa of Fabricius. On the basis of organ distribution, latent period, pathology and surface IgM production, the lymphomas closely resembled those of lymphoid leukosis. One inoculated chicken developed a myxosarcoma. No tumors were observed in un‐inoculated controls. The tumor‐bearing chickens were free of infection with Marek's disease virus and exogenous avian leukosis virus (ALV) of subgroups A, B, C or D. However, the chickens were known to express endogenous ALV genes to varying degrees.

[1]  P. Neiman,et al.  Lymphoid neoplasms in chicken flocks free of infection with exogenous avian tumor viruses. , 1979, Journal of the National Cancer Institute.

[2]  R. Witter,et al.  Differential Diagnosis of Lymphoid Leukosis and Marek's Disease by Tumor-Associated Criteria , 1979 .

[3]  H. Bose,,et al.  Transformation by reticuloendotheliosis virus: development of a focus assay and isolation of a nontransforming virus. , 1979, Virology.

[4]  T. Bagust,et al.  Experimental infection of chickens with an australian strain of reticuloendotheliosis virus. I. Clinical, pathological and haematological effects. , 1979, Avian pathology : journal of the W.V.P.A.

[5]  P. Biggs,et al.  A leukosis in turkeys associated with infection with reticuloendotheliosis virus. , 1978, Avian pathology : journal of the W.V.P.A.

[6]  E. Hunter,et al.  Amino-terminal amino acid sequence of the major structural polypeptides of avian retroviruses: sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. Ianconescu,et al.  Persistent viraemia in chickens subsequent to in ovo inoculation of reticuloendotheliosis virus. , 1978, Avian pathology : journal of the W.V.P.A.

[8]  Y. Chien,et al.  High-molecular-weight RNAs of AKR, NZB, and wild mouse viruses and avian reticuloendotheliosis virus all have similar dimer structures , 1978, Journal of virology.

[9]  H. Hanafusa,et al.  Recovery of avian sarcoma virus from tumors induced by transformation- defective mutants , 1977, The Journal of experimental medicine.

[10]  E. Smith,et al.  Complement-fixation test for reticuloendotheliosis viruses: limits of sensitivity in infected avian cells. , 1977, Avian diseases.

[11]  H. Bose,,et al.  Contact-mediated suppression of mitogen-induced responsiveness by spleen cells in reticuloendotheliosis virus-induced tumorigenesis. , 1977, Cellular immunology.

[12]  S. E. Dunn,et al.  Proventriculitis, "nakanuke" and reticuloendotheliosis in chickens following vaccination with herpesvirus of turkeys (HVT) , 1977, Australian veterinary journal.

[13]  P. Vogt,et al.  Phenotypic mixing between reticuloendotheliosis virus and avian sarcoma viruses. , 1977, Virology.

[14]  H. Hanafusa,et al.  Formation of reticuloendotheliosis virus pseudotypes of Rous sarcoma virus , 1977, Journal of virology.

[15]  E. Smith.  Preparation of antisera to group-specific antigens of avian leukosis-sarcoma viruses: an alternate approach. , 1977, Avian diseases.

[16]  C. Muscoplat,et al.  Characteristics of two new reticuloendotheliosis virus isolates of turkeys. , 1977, American journal of veterinary research.

[17]  V. V. Bülow.  Immunological effects of reticuloendotheliosis virus as potential contaminant of Marek's disease vaccines. , 1977, Avian pathology : journal of the W.V.P.A.

[18]  R. Witter,et al.  Studies on the etiology of lymphomas in turkeys: isolation of reticuloendotheliosis in virus. , 1976, Avian diseases.

[19]  Y. Saito,et al.  Reticuloendotheliosis group virus pathogenic to chicken isolated from material infected with turkey herpesvirus (HVT). , 1976, Avian diseases.

[20]  P. Duesberg,et al.  Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses , 1976, Journal of virology.

[21]  K. Schat,et al.  A lymphoproliferative disease in Japanese Quail. , 1976, Avian diseases.

[22]  S. Yamaguchi,et al.  Inoculation experiment of Marek's disease vaccine contaminated with a reticuloendotheliosis virus. , 1976, National Institute of Animal Health quarterly.

[23]  R. Witter,et al.  Demonstration of a tumor-associated surface antigen in Marek's disease. , 1975, Journal of immunology.

[24]  G. Pauli,et al.  A comparative study of the avian reticuloendotheliosis virus: relationship to murine leukemia virus and viruses of the avian sarcoma-leukosis complex. , 1975, Virology.

[25]  P. Paul,et al.  Isolation and characterization of viruses from natural outbreaks of reticuloendotheliosis in turkeys. , 1975, Journal of the National Cancer Institute.

[26]  M. Collett,et al.  Studies on the replication of reticuloendotheliosis virus: detection of viral-specific DNA sequences in infected chick cells. , 1975, Virology.

[27]  H. Temin,et al.  Reticuloendotheliosis Virus Nucleic Acid Sequences in Cellular DNA , 1974, Journal of virology.

[28]  H. C. Carlson,et al.  Reticuloendotheliosis in Japanese quail. , 1974, Avian pathology : journal of the W.V.P.A.

[29]  Robinson Fr,et al.  Isolation of tha avian reticuloendothelial virus (strain T). , 1974 .

[30]  H. Temin,et al.  Lack of Sequence Homology Among RNAs of Avian Leukosis-Sarcoma Viruses, Reticuloendotheliosis Viruses, and Chicken Endogenous RNA-Directed DNA Polymerase Activity , 1973, Journal of virology.

[31]  H. Purchase,et al.  Reticuloendotheliosis in a duck. , 1973, Australian veterinary journal.

[32]  S. Mizutani,et al.  Lack of Serological Relationship Among DNA Polymerases of Avian Leukosis-Sarcoma Viruses, Reticuloendotheliosis Viruses, and Chicken Cells , 1973, Journal of virology.

[33]  H. Purchase,et al.  A new group of oncogenic viruses: reticuloendotheliosis, chick syncytial, duck infectious anemia, and spleen necrosis viruses. , 1973, Journal of the National Cancer Institute.

[34]  M. Halpern,et al.  A study of the relationship of reticuloendotheliosis virus to the avian leukosis-sarcoma complex of viruses. , 1973, Virology.

[35]  Reynaldo L. Maldonado,et al.  Relationship of Reticuloendotheliosis Virus to the Avian Tumor Viruses: Nucleic Acid and Polypeptide Composition , 1973, Journal of virology.

[36]  H. Purchase,et al.  Duck infectious anemia virus associated with Plasmodium lophurae. , 1972, Experimental parasitology.

[37]  H. Bose,,et al.  Separation of Reticuloendotheliosis Virus from Avian Tumor Viruses , 1971, Journal of virology.

[38]  M. J. Twiehaus,et al.  Pathogenesis of reticuloendothelial virus disease in chicks--an acute runting syndrome. , 1971, Avian diseases.

[39]  R. Witter,et al.  Peripheral nerve lesions similar to those of Marek's disease in chickens inoculated with reticuloendotheliosis virus. , 1970, Journal of the National Cancer Institute.

[40]  M. Cook.  Cultivation of a filterable agent associated with Marek's disease. , 1969, Journal of the National Cancer Institute.

[41]  R. Zeigel,et al.  Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. , 1966, Journal of the National Cancer Institute.

[42]  R. Zeigel,et al.  Electron microscopic observations on RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. , 1966, Journal of the National Cancer Institute.

[43]  P. Vogt,et al.  Immunological relationships among envelope antigens of avian tumor viruses. , 1966, Virology.

[44]  H. Rubin,et al.  Tolerance and immunity in chickens after congenital and contact infection with an avian leukosis virus. , 1962, Virology.

[45]  W. Trager.  A New Virus of Ducks Interfering with Development of Malaria Parasite (Plasmodium lophurae). , 1959, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.