Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus

[1]  Andrea Di Gioacchino,et al.  Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape , 2023, bioRxiv.

[2]  A. Sandelin,et al.  Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression , 2022, Molecular cell.

[3]  T. Mustelin,et al.  IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus , 2021, Arthritis Research & Therapy.

[4]  J. Boeke,et al.  RIP-seq reveals LINE-1 ORF1p association with p-body enriched mRNAs , 2021, Mobile DNA.

[5]  T. Mustelin,et al.  Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus , 2021, Journal of clinical medicine.

[6]  Helen M. Rowe,et al.  The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s , 2020, Nature Communications.

[7]  M. Pasparakis,et al.  Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation , 2020, Nature.

[8]  T. Mustelin,et al.  High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus , 2020, Arthritis & rheumatology.

[9]  J. Boeke,et al.  Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function , 2019, Genetics.

[10]  J. Boeke,et al.  Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function , 2019, Genetics.

[11]  Jinchuan Xing,et al.  SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina , 2019, Nucleic acids research.

[12]  J. Boeke,et al.  LINE-1 derepression in senescent cells triggers interferon and inflammaging , 2018, Nature.

[13]  Y. Crow,et al.  Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome , 2018, The New England journal of medicine.

[14]  H. Shu,et al.  ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response , 2018, Nature Communications.

[15]  Helen M. Rowe,et al.  The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes , 2018, Genome research.

[16]  B. Chait,et al.  Dissection of affinity captured LINE-1 macromolecular complexes , 2018, eLife.

[17]  T. Kanneganti,et al.  ZBP1: Innate Sensor Regulating Cell Death and Inflammation. , 2017, Trends in immunology.

[18]  M. Crow,et al.  Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes. , 2017, Journal of autoimmunity.

[19]  A. Muotri,et al.  Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. , 2017, Cell stem cell.

[20]  P. Jagodziński,et al.  Decreased mRNA expression levels of DNA methyltransferases type 1 and 3A in systemic lupus erythematosus , 2017, Rheumatology International.

[21]  H. Kazazian,et al.  Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion , 2017, Nucleic acids research.

[22]  M. Crow,et al.  Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease , 2016, Arthritis & rheumatology.

[23]  P. Gaffney,et al.  Expression and methylation data from SLE patient and healthy control blood samples subdivided with respect to ARID3a levels , 2016, Data in brief.

[24]  Ying Jin,et al.  TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets , 2015, Bioinform..

[25]  Gene W. Yeo,et al.  The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression , 2015, Science.

[26]  Zhijian J. Chen,et al.  Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases , 2015, Proceedings of the National Academy of Sciences.

[27]  Xiaoqin Xu,et al.  Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome , 2015, eLife.

[28]  Jian Li,et al.  SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation , 2015, PLoS genetics.

[29]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[30]  S. Ohms,et al.  LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer? , 2014, Front. Genet..

[31]  Anthony J. Geneva,et al.  SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age , 2014, Nature Communications.

[32]  Martin S. Taylor,et al.  Expression and detection of LINE-1 ORF-encoded proteins , 2014, Mobile genetic elements.

[33]  Martin S. Taylor,et al.  Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition , 2013, Cell.

[34]  J. B. Díaz-lópez,et al.  Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus , 2013, TheScientificWorldJournal.

[35]  X. Li,et al.  Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity. , 2013, Journal of dermatological science.

[36]  H. Kazazian,et al.  Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition , 2013, Nucleic acids research.

[37]  A. Bowie,et al.  Cytosolic DNA sensors regulating type I interferon induction. , 2011, Trends in immunology.

[38]  R. Ghirlando,et al.  Polymerization and nucleic acid-binding properties of human L1 ORF1 protein , 2011, Nucleic acids research.

[39]  Steffen Schmidt,et al.  Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition , 2011, Nature Structural &Molecular Biology.

[40]  T. Jensen,et al.  Interaction profiling identifies the human nuclear exosome targeting complex. , 2011, Molecular cell.

[41]  J. Boeke,et al.  Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition , 2011, BMC Biochemistry.

[42]  Sandra L. Martin,et al.  Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1 , 2010, RNA biology.

[43]  J. V. Moran,et al.  Characterization of LINE-1 Ribonucleoprotein Particles , 2010, PLoS genetics.

[44]  H. Kazazian,et al.  Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion. , 2010, Human molecular genetics.

[45]  D. Nixon,et al.  Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition , 2008, PloS one.

[46]  H. Kazazian,et al.  LINE-1 ORF1 Protein Localizes in Stress Granules with Other RNA-Binding Proteins, Including Components of RNA Interference RNA-Induced Silencing Complex , 2007, Molecular and Cellular Biology.

[47]  Ivan N. Shatsky,et al.  Efficient Translation Initiation Directed by the 900-Nucleotide-Long and GC-Rich 5′ Untranslated Region of the Human Retrotransposon LINE-1 mRNA Is Strictly Cap Dependent Rather than Internal Ribosome Entry Site Mediated , 2007, Molecular and Cellular Biology.

[48]  Sandra L. Martin,et al.  The ORF1 Protein Encoded by LINE-1: Structure and Function During L1 Retrotransposition , 2006, Journal of biomedicine & biotechnology.

[49]  J. V. Moran,et al.  Unconventional translation of mammalian LINE-1 retrotransposons. , 2006, Genes & development.

[50]  H. Shin,et al.  Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus , 2004, Journal of Human Genetics.

[51]  M. Crow,et al.  Microarray Analysis of Interferon-regulated Genes in SLE , 2003, Autoimmunity.

[52]  J. V. Moran,et al.  Hot L1s account for the bulk of retrotransposition in the human population , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Virginia Pascual,et al.  Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood , 2003, The Journal of experimental medicine.

[54]  G. Karypis,et al.  Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[55]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[56]  E. Ostertag,et al.  Biology of mammalian L1 retrotransposons. , 2001, Annual review of genetics.

[57]  P. Dhakephalkar,et al.  Ro60 Peptides Induce Antibodies to Similar Epitopes Shared Among Lupus-Related Autoantigens1 , 2000, The Journal of Immunology.

[58]  Thierry Heidmann,et al.  Human LINE retrotransposons generate processed pseudogenes , 2000, Nature Genetics.

[59]  M. Singer,et al.  The human LINE-1 reverse transcriptase:effect of deletions outside the common reverse transcriptase domain. , 1998, Nucleic acids research.

[60]  H. Hohjoh,et al.  Cytoplasmic ribonucleoprotein complexes containing human LINE‐1 protein and RNA. , 1996, The EMBO journal.

[61]  T. Eickbush,et al.  Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: A mechanism for non-LTR retrotransposition , 1993, Cell.

[62]  J. Boeke,et al.  Reverse transcriptase encoded by a human transposable element. , 1991, Science.

[63]  S. Hanash,et al.  Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. , 1988, Journal of immunology.

[64]  R. Palmiter,et al.  Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation , 1983, Cell.

[65]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[66]  International Human Genome Sequencing Consortium.  Initial sequencing and analysis of the human genome , 2001, Nature.