Association of Umbilical Cord Serum Oxidative Stress Markers, ADMA and Adiponectin with Adverse Fetal Outcomes in Hypertensive Disorders of Pregnancy

Abstract Background: Limited studies are available on fetal oxidative stress and endothelial dysfunction and their association with adverse fetal outcomes in hypertensive disorders of pregnancy (HDP). Method: Umbilical cord blood samples were collected at delivery from 134 pregnant women with HDP and 59 controls. Markers of oxidative stress, endothelial dysfunction and inflammation and adipokines were analyzed. Results were correlated with adverse fetal outcomes. Results: Malondialdehyde, total antioxidant status(TAS), ADMA and hsCRP levels were increased in late and early onset preeclampsia. Adiponectin levels were decreased in early onset preeclampsia. High ADMA levels were positively associated with preterm births and fetal mortality and high TAS, protein carbonyl content(PC), ADMA and low adiponectin levels were positively associated with low birth weight babies. Conclusion: Fetal systemic oxidative stress, endothelial dysfunction and inflammation were altered in early and late onset preeclampsia. High TAS, PC and ADMA levels and low adiponectin levels were positively associated with adverse fetal outcomes in HDP.

[1]  M. E. Moreira,et al.  Pregnancy-induced hypertension, preterm birth, and cord blood adipokine levels , 2020, European Journal of Pediatrics.

[2]  Yinglong Hou,et al.  Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis , 2020, BMC Cardiovascular Disorders.

[3]  Anuragini Gupta,et al.  Hypertensive Disorders of Pregnancy. , 2007, Cardiology clinics.

[4]  A. Taravati,et al.  Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia. , 2018, Taiwanese journal of obstetrics & gynecology.

[5]  W. H. Pearse,et al.  American College of Obstetricians and Gynecologists , 2018, Definitions.

[6]  Shruti Bharadwaj,et al.  Oxidative stress in preeclamptic mother – newborn dyads and its correlation with early neonatal outcome – a case control study , 2018, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[7]  Daniel Vaiman,et al.  Oxidative Stress in Preeclampsia and Placental Diseases , 2018, International journal of molecular sciences.

[8]  M. Owens,et al.  Pathophysiology and Current Clinical Management of Preeclampsia , 2017, Current Hypertension Reports.

[9]  M. Rodger,et al.  Comparison of risk factors and outcomes of gestational hypertension and pre-eclampsia , 2017, PloS one.

[10]  S. Kharb,et al.  Patterns of Biomarkers in Cord Blood During Pregnancy and Preeclampsia. , 2017, Current hypertension reviews.

[11]  M. A. Atalay,et al.  Possible role of asymmetric dimethylarginine (ADMA) in prediction of perinatal outcome in preeclampsia and fetal growth retardation related to preeclampsia , 2016, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[12]  L. Amaral,et al.  The role of inflammation in the pathology of preeclampsia. , 2016, Clinical science.

[13]  M. Christiansen,et al.  Adipokines in umbilical cord blood from children born large for gestational age , 2016, Journal of pediatric endocrinology & metabolism : JPEM.

[14]  S. Davidge,et al.  Molecular mechanisms of maternal vascular dysfunction in preeclampsia. , 2015, Trends in molecular medicine.

[15]  A. Shennan,et al.  Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. , 2015, Obstetrics and gynecology.

[16]  Joy Lawn,et al.  Born Too Soon: The global epidemiology of 15 million preterm births , 2013, Reproductive Health.

[17]  G. Kovacs,et al.  L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies , 2013, Scandinavian journal of clinical and laboratory investigation.

[18]  Aaron B. Caughey,et al.  Hypertensive disease of pregnancy and maternal mortality , 2013, Current opinion in obstetrics & gynecology.

[19]  K. Karki,et al.  Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation. , 2012, Clinical nutrition.

[20]  Y. Tain,et al.  Roles of Nitric Oxide and Asymmetric Dimethylarginine in Pregnancy and Fetal Programming , 2012, International journal of molecular sciences.

[21]  I. Rebelo,et al.  Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood , 2012, Journal of pregnancy.

[22]  Reem Mustafa,et al.  A Comprehensive Review of Hypertension in Pregnancy , 2012, Journal of pregnancy.

[23]  K. Hecher,et al.  Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia. , 2012, European journal of obstetrics, gynecology, and reproductive biology.

[24]  M. Fasshauer,et al.  Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre‐eclampsia , 2012, Clinical endocrinology.

[25]  Marcelo González,et al.  Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia , 2011, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[26]  Shufeng Zhou,et al.  Alternations of Maternal and Cord Plasma Hemostasis in Preeclampsia Before and After Delivery , 2011, Hypertension in pregnancy.

[27]  P. Legendre,et al.  Von Willebrand Factor and ADAMTS13: A Candidate Couple for Preeclampsia Pathophysiology , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[28]  K. Bharati,et al.  Von Willebrand Disease: An Overview , 2011, Indian journal of pharmaceutical sciences.

[29]  L. Vatten,et al.  Preeclampsia and Adiponectin in Cord Blood , 2010, Hormone Research in Paediatrics.

[30]  T. Khan,et al.  Oxidative stress and antioxidant status in neonates born to pre-eclamptic mother. , 2009, Journal of tropical pediatrics.

[31]  A. Malamitsi‐Puchner,et al.  Reviews: Adipocytokines in Normal and Complicated Pregnancies , 2009, Reproductive Sciences.

[32]  H. Tsukahara,et al.  Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood. , 2008, Metabolism: clinical and experimental.

[33]  H. Kim,et al.  Correlations between umbilical and maternal serum resistin levels and neonatal birth weight , 2006, Acta obstetricia et gynecologica Scandinavica.

[34]  E. Gozukara,et al.  Maternal and fetal plasma adenosine deaminase, xanthine oxidase and malondialdehyde levels in pre‐eclampsia , 2005, Cell biochemistry and function.

[35]  E. Kajantie,et al.  Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term. , 2004, The Journal of clinical endocrinology and metabolism.

[36]  D. Eichler,et al.  Correlates of Adiponectin and the Leptin/Adiponectin Ratio in Obese and Non-obese Children , 2004, Journal of pediatric endocrinology & metabolism : JPEM.

[37]  P. Wardas,et al.  [Malondialdehyde (MDA) as a lipid peroxidation marker]. , 2004, Wiadomosci lekarskie.

[38]  L. Magee,et al.  Subclassification of Preeclampsia , 2003, Hypertension in pregnancy.

[39]  N. Vitoratos,et al.  Alterations of maternal and fetal leptin concentrations in hypertensive disorders of pregnancy. , 2001, European journal of obstetrics, gynecology, and reproductive biology.

[40]  H. Kato,et al.  Fetal plasma lipid peroxide levels in pregnancies complicated by preeclampsia. , 1997, Gynecologic and obstetric investigation.

[41]  J J Strain,et al.  The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. , 1996, Analytical biochemistry.