Photoacoustic tomography imaging using a 4f acoustic lens and peak-hold technology.

In this paper we present a new high-contrast photoacoustic tomography (PAT) imaging system using a 4f acoustic lens, a 64-element linear transducer array and peak-hold technology. This PAT imaging system has been developed to obtain three-dimensional (3D) PAT images of experimental samples. By utilizing a 4f acoustic lens, the photoacoustic (PA) signals generated from the sample are directly imaged on the imaging plane and collected by the 64-element linear transducer array, which changes them into the corresponding electronic signals. Then we can get one-dimensional (1D) images from the electronic signals using a peak detection-and-hold circuit. After vertical scanning with a stepping motor on the imaging plane, a 2D PA image of the sample is successfully obtained. Combined with the time-resolved technique, we can then get 3D PAT images. The results show that the reconstructed images agree well with the original samples.

[1]  Geng Ku,et al.  Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. , 2006, Journal of biomedical optics.

[2]  Erwin Hondebrink,et al.  Photoacoustic determination of blood vessel diameter. , 2004, Physics in medicine and biology.

[3]  The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system , 2007 .

[4]  Lihong V. Wang,et al.  Photoacoustic imaging in biomedicine , 2006 .

[5]  Zhilie Tang,et al.  Photoacoustic tomography imaging based on a 4f acoustic lens imaging system. , 2007, Optics express.

[6]  K. P. Köstli,et al.  Two-dimensional photoacoustic imaging by use of Fourier-transform image reconstruction and a detector with an anisotropic response. , 2003, Applied optics.

[7]  Da Xing,et al.  Photoacoustic imaging with deconvolution algorithm. , 2004, Physics in medicine and biology.

[8]  Da Xing,et al.  Fast photoacoustic imaging system based on 320-element linear transducer array. , 2004, Physics in medicine and biology.

[9]  Lihong V. Wang,et al.  In vivo volumetric imaging of subcutaneous microvasculature by photoacoustic microscopy. , 2006, Optics express.

[10]  Martin Frenz,et al.  Real-time three-dimensional optoacoustic imaging using an acoustic lens system , 2004 .

[11]  Ronald I. Siphanto,et al.  Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis. , 2005, Optics express.

[12]  Da Xing,et al.  Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm , 2005 .

[13]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[14]  Kwang Hyun Song,et al.  In vivo three-dimensional photoacoustic tomography of a whole mouse head. , 2006, Optics letters.

[15]  Alexander A. Oraevsky,et al.  Laser optoacoustic imaging of breast cancer in vivo , 2001, SPIE BiOS.

[16]  Minghua Xu,et al.  Time-domain reconstruction for thermoacoustic tomography in a spherical geometry , 2002, IEEE Transactions on Medical Imaging.

[17]  F. D. de Mul,et al.  Three-dimensional photoacoustic imaging of blood vessels in tissue. , 1998, Optics letters.