Human T regulatory cell therapy: take a billion or so and call me in the morning.

[1]  M. A. Curotto de Lafaille,et al.  Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? , 2009, Immunity.

[2]  D. Littman,et al.  Plasticity of CD4+ T cell lineage differentiation. , 2009, Immunity.

[3]  E. Shevach Mechanisms of foxp3+ T regulatory cell-mediated suppression. , 2009, Immunity.

[4]  A. Rudensky,et al.  Control of regulatory T cell lineage commitment and maintenance. , 2009, Immunity.

[5]  E. Elinav,et al.  Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. , 2009, Gastroenterology.

[6]  R. Friedline,et al.  CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance , 2009, The Journal of Experimental Medicine.

[7]  G. Szot,et al.  Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes , 2009, Diabetes.

[8]  B. Malissen,et al.  Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity , 2009, Proceedings of the National Academy of Sciences.

[9]  G. Nepom,et al.  Animal models of human type 1 diabetes , 2009, Nature Immunology.

[10]  M. Ehrenstein,et al.  Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis , 2008, Proceedings of the National Academy of Sciences.

[11]  J. Buckner,et al.  The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells1 , 2008, The Journal of Immunology.

[12]  R. Phillips,et al.  Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor , 2008, Nature Medicine.

[13]  M. Bhasin,et al.  Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice , 2008, Proceedings of the National Academy of Sciences.

[14]  A. Churg,et al.  α1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice , 2008, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Nomura,et al.  CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.

[16]  J. Wagner,et al.  Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. , 2008, Blood.

[17]  Erin L. Schenk,et al.  Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo1 , 2008, The Journal of Immunology.

[18]  B. Levine,et al.  CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function1 , 2008, The Journal of Immunology.

[19]  Chen Dong,et al.  Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. , 2008, Immunity.

[20]  Yong‐jun Liu,et al.  Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. , 2008, Immunity.

[21]  K. Scalapino,et al.  CTLA‐4: a key regulatory point in the control of autoimmune disease , 2008, Immunological reviews.

[22]  B. Schraven,et al.  CD28 superagonists: what makes the difference in humans? , 2008, Immunity.

[23]  M. Richer,et al.  Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor-β , 2008, Diabetes.

[24]  C. June,et al.  Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin1 , 2008, The Journal of Immunology.

[25]  B. '. ’t Hart,et al.  Characterization of Naturally Occurring CD4+CD25+ Regulatory T Cells in Rhesus Monkeys , 2008, Transplantation.

[26]  Qizhi Tang,et al.  The Foxp3+ regulatory T cell: a jack of all trades, master of regulation , 2008, Nature Immunology.

[27]  A. Adjei,et al.  Small cell lung cancer. , 2008, Mayo Clinic proceedings.

[28]  Ke Chen,et al.  T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren's syndrome. , 2007, The Journal of rheumatology.

[29]  T. Yi,et al.  In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. , 2007, Blood.

[30]  D. Munn,et al.  The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation. , 2007 .

[31]  E. Olson,et al.  Deacetylase inhibition promotes the generation and function of regulatory T cells , 2007, Nature Medicine.

[32]  T. Gajewski The expanding universe of regulatory T cell subsets in cancer. , 2007, Immunity.

[33]  R. Noelle,et al.  All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation , 2007, The Journal of experimental medicine.

[34]  Aarati R. Ranade,et al.  Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice , 2007, Nature Biotechnology.

[35]  P. Krammer,et al.  Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis1 , 2007, The Journal of Immunology.

[36]  W. Leonard,et al.  CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation , 2007, The Journal of experimental medicine.

[37]  C. June,et al.  Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

[38]  C. June,et al.  Principles of adoptive T cell cancer therapy. , 2007, The Journal of clinical investigation.

[39]  V. Kuchroo,et al.  Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation , 2007, Nature Medicine.

[40]  K. Pattanapanyasat,et al.  The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. , 2007, Journal of autoimmunity.

[41]  M. Atkinson,et al.  No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes , 2007, Diabetes.

[42]  P. Lipsky,et al.  Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus1 , 2007, The Journal of Immunology.

[43]  Dale L. Greiner,et al.  Humanized mice in translational biomedical research , 2007, Nature Reviews Immunology.

[44]  R. Steinman,et al.  Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice , 2007, The Journal of experimental medicine.

[45]  R. Andreesen,et al.  Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. , 2006, Blood.

[46]  M. Battaglia,et al.  Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 , 2006, The Journal of Immunology.

[47]  John R. Mascola,et al.  Gene transfer in humans using a conditionally replicating lentiviral vector , 2006, Proceedings of the National Academy of Sciences.

[48]  Nicki Panoskaltsis,et al.  Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. , 2006, The New England journal of medicine.

[49]  R. González-Amaro,et al.  Regulatory T cells in patients with systemic lupus erythematosus. , 2006, Journal of autoimmunity.

[50]  Shimon Sakaguchi,et al.  Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease , 2006, Immunological reviews.

[51]  C. Baecher-Allan,et al.  Human regulatory T cells and their role in autoimmune disease , 2006, Immunological reviews.

[52]  W. Zou,et al.  Regulatory T-cell compartmentalization and trafficking. , 2006, Blood.

[53]  T. Gingeras,et al.  CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells , 2006, The Journal of experimental medicine.

[54]  Mario Roederer,et al.  HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. , 2006, Blood.

[55]  B. Fox,et al.  Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX® vaccine in advanced-stage non-small-cell lung cancer , 2006, Cancer Gene Therapy.

[56]  C. June,et al.  Clinical application of expanded CD4+25+ cells. , 2006, Seminars in immunology.

[57]  P. Debré,et al.  Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus1 , 2005, The Journal of Immunology.

[58]  C. Benoist,et al.  Where CD4+CD25+ T reg cells impinge on autoimmune diabetes , 2005, The Journal of experimental medicine.

[59]  P. Krammer,et al.  Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis , 2005, European journal of immunology.

[60]  R. Gold,et al.  Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis , 2005, The Journal of experimental medicine.

[61]  M. Battaglia,et al.  Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. , 2005, Blood.

[62]  Jeffrey C. Miller,et al.  Highly efficient endogenous human gene correction using designed zinc-finger nucleases , 2005, Nature.

[63]  Megan Sykes,et al.  Organ transplantation—how much of the promise has been realized? , 2005, Nature Medicine.

[64]  J. Bluestone,et al.  FOCIS abstract supplement , 2005, Clinical Immunology.

[65]  T. Geiger,et al.  Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes. , 2005, Blood.

[66]  A. Rudensky,et al.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.

[67]  A. Hanash,et al.  Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. , 2005, Blood.

[68]  J. Serody,et al.  L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. , 2004, Blood.

[69]  M. V. von Herrath,et al.  Initiation of autoimmunity. , 2004, Current opinion in immunology.

[70]  B. Levine,et al.  Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. , 2004, Blood.

[71]  M. Shlomchik,et al.  Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. , 2004, Blood.

[72]  B. Levine,et al.  In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. , 2004, Blood.

[73]  R. Andreesen,et al.  Large scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells , 2004, Cancer Cell International.

[74]  Jeffrey A. Bluestone,et al.  In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.

[75]  O. Joffre,et al.  Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. , 2004, Blood.

[76]  Clare Baecher-Allan,et al.  Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis , 2004, The Journal of experimental medicine.

[77]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[78]  D. Klatzmann,et al.  Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. , 2003, The Journal of clinical investigation.

[79]  T. Strom,et al.  CD154 on the surface of CD4+CD25+ regulatory t cells contributes to skin transplant tolerance , 2003, Transplantation.

[80]  J. Alcocer-Varela,et al.  Quantification of regulatory T cells in patients with systemic lupus erythematosus. , 2003, Journal of autoimmunity.

[81]  T. Hünig,et al.  Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist , 2003, European journal of immunology.

[82]  K. Wood,et al.  Regulatory lymphocytes: Regulatory T cells in transplantation tolerance , 2003, Nature Reviews Immunology.

[83]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[84]  C. Fathman,et al.  The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR71 , 2002, The Journal of Immunology.

[85]  David Klatzmann,et al.  CD4+CD25+ Immunoregulatory T Cells , 2002, The Journal of experimental medicine.

[86]  C. Fathman,et al.  Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation , 2002, The Journal of experimental medicine.

[87]  Michael S. Kuhns,et al.  CTLA-4: new insights into its biological function and use in tumor immunotherapy , 2002, Nature Immunology.

[88]  A. Coutinho,et al.  Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[89]  B. Blazar,et al.  The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. , 2002, Blood.

[90]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[91]  T. Strom,et al.  Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance1 , 2002, The Journal of Immunology.

[92]  R. Noelle,et al.  Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade , 2001, The Journal of experimental medicine.

[93]  N. Sarvetnick,et al.  CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection. , 1999, Journal of immunology.

[94]  J. Lafaille,et al.  Regulatory Cd4 Ϩ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis , 1998 .

[95]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[96]  B. Hall,et al.  Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action , 1990, The Journal of experimental medicine.

[97]  Joseph Y. Halpern,et al.  [Small-cell lung cancer]. , 1984, Harefuah.

[98]  R. Gershon A Disquisition on Suppressor T Cells , 1975, Transplantation reviews.

[99]  C. Piccirillo CD4 + Foxp3 + Regulatory T Cells in Immune Tolerance , 2008 .

[100]  G. Galbraith Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412Suntharalingam G, Perry MR, Ward S, et al (Northwick Park and St Mark's Hosp, London; Hammersmith Hosp, London; Imperial College, London) N Engl J Med 355:1018–1028, 2006§ , 2007 .

[101]  Mark S. Anderson,et al.  The NOD mouse: a model of immune dysregulation. , 2005, Annual review of immunology.

[102]  C. June,et al.  The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. , 2005, Blood.

[103]  M. Peakman,et al.  Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. , 2005, Diabetes.

[104]  Svetlana Ten,et al.  Multiple immuno-regulatory defects in type-1 diabetes. , 2002, The Journal of clinical investigation.

[105]  J. Kroepfl,et al.  Myelin/Oligodendrocyte Glycoprotein , 1997 .

[106]  A. Singer,et al.  Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. , 1992, Annual review of immunology.