Human T regulatory cell therapy: take a billion or so and call me in the morning.
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[1] M. A. Curotto de Lafaille,et al. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? , 2009, Immunity.
[2] D. Littman,et al. Plasticity of CD4+ T cell lineage differentiation. , 2009, Immunity.
[3] E. Shevach. Mechanisms of foxp3+ T regulatory cell-mediated suppression. , 2009, Immunity.
[4] A. Rudensky,et al. Control of regulatory T cell lineage commitment and maintenance. , 2009, Immunity.
[5] E. Elinav,et al. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. , 2009, Gastroenterology.
[6] R. Friedline,et al. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance , 2009, The Journal of Experimental Medicine.
[7] G. Szot,et al. Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes , 2009, Diabetes.
[8] B. Malissen,et al. Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity , 2009, Proceedings of the National Academy of Sciences.
[9] G. Nepom,et al. Animal models of human type 1 diabetes , 2009, Nature Immunology.
[10] M. Ehrenstein,et al. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis , 2008, Proceedings of the National Academy of Sciences.
[11] J. Buckner,et al. The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells1 , 2008, The Journal of Immunology.
[12] R. Phillips,et al. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor , 2008, Nature Medicine.
[13] M. Bhasin,et al. Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice , 2008, Proceedings of the National Academy of Sciences.
[14] A. Churg,et al. α1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice , 2008, Proceedings of the National Academy of Sciences of the United States of America.
[15] T. Nomura,et al. CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.
[16] J. Wagner,et al. Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. , 2008, Blood.
[17] Erin L. Schenk,et al. Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo1 , 2008, The Journal of Immunology.
[18] B. Levine,et al. CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function1 , 2008, The Journal of Immunology.
[19] Chen Dong,et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. , 2008, Immunity.
[20] Yong‐jun Liu,et al. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. , 2008, Immunity.
[21] K. Scalapino,et al. CTLA‐4: a key regulatory point in the control of autoimmune disease , 2008, Immunological reviews.
[22] B. Schraven,et al. CD28 superagonists: what makes the difference in humans? , 2008, Immunity.
[23] M. Richer,et al. Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor-β , 2008, Diabetes.
[24] C. June,et al. Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin1 , 2008, The Journal of Immunology.
[25] B. '. ’t Hart,et al. Characterization of Naturally Occurring CD4+CD25+ Regulatory T Cells in Rhesus Monkeys , 2008, Transplantation.
[26] Qizhi Tang,et al. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation , 2008, Nature Immunology.
[27] A. Adjei,et al. Small cell lung cancer. , 2008, Mayo Clinic proceedings.
[28] Ke Chen,et al. T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren's syndrome. , 2007, The Journal of rheumatology.
[29] T. Yi,et al. In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. , 2007, Blood.
[30] D. Munn,et al. The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation. , 2007 .
[31] E. Olson,et al. Deacetylase inhibition promotes the generation and function of regulatory T cells , 2007, Nature Medicine.
[32] T. Gajewski. The expanding universe of regulatory T cell subsets in cancer. , 2007, Immunity.
[33] R. Noelle,et al. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation , 2007, The Journal of experimental medicine.
[34] Aarati R. Ranade,et al. Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice , 2007, Nature Biotechnology.
[35] P. Krammer,et al. Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis1 , 2007, The Journal of Immunology.
[36] W. Leonard,et al. CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation , 2007, The Journal of experimental medicine.
[37] C. June,et al. Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[38] C. June,et al. Principles of adoptive T cell cancer therapy. , 2007, The Journal of clinical investigation.
[39] V. Kuchroo,et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation , 2007, Nature Medicine.
[40] K. Pattanapanyasat,et al. The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. , 2007, Journal of autoimmunity.
[41] M. Atkinson,et al. No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes , 2007, Diabetes.
[42] P. Lipsky,et al. Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus1 , 2007, The Journal of Immunology.
[43] Dale L. Greiner,et al. Humanized mice in translational biomedical research , 2007, Nature Reviews Immunology.
[44] R. Steinman,et al. Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice , 2007, The Journal of experimental medicine.
[45] R. Andreesen,et al. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. , 2006, Blood.
[46] M. Battaglia,et al. Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 , 2006, The Journal of Immunology.
[47] John R. Mascola,et al. Gene transfer in humans using a conditionally replicating lentiviral vector , 2006, Proceedings of the National Academy of Sciences.
[48] Nicki Panoskaltsis,et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. , 2006, The New England journal of medicine.
[49] R. González-Amaro,et al. Regulatory T cells in patients with systemic lupus erythematosus. , 2006, Journal of autoimmunity.
[50] Shimon Sakaguchi,et al. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease , 2006, Immunological reviews.
[51] C. Baecher-Allan,et al. Human regulatory T cells and their role in autoimmune disease , 2006, Immunological reviews.
[52] W. Zou,et al. Regulatory T-cell compartmentalization and trafficking. , 2006, Blood.
[53] T. Gingeras,et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells , 2006, The Journal of experimental medicine.
[54] Mario Roederer,et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. , 2006, Blood.
[55] B. Fox,et al. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX® vaccine in advanced-stage non-small-cell lung cancer , 2006, Cancer Gene Therapy.
[56] C. June,et al. Clinical application of expanded CD4+25+ cells. , 2006, Seminars in immunology.
[57] P. Debré,et al. Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus1 , 2005, The Journal of Immunology.
[58] C. Benoist,et al. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes , 2005, The Journal of experimental medicine.
[59] P. Krammer,et al. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis , 2005, European journal of immunology.
[60] R. Gold,et al. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis , 2005, The Journal of experimental medicine.
[61] M. Battaglia,et al. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. , 2005, Blood.
[62] Jeffrey C. Miller,et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases , 2005, Nature.
[63] Megan Sykes,et al. Organ transplantation—how much of the promise has been realized? , 2005, Nature Medicine.
[64] J. Bluestone,et al. FOCIS abstract supplement , 2005, Clinical Immunology.
[65] T. Geiger,et al. Immunotherapy of autoimmune encephalomyelitis with redirected CD4+CD25+ T lymphocytes. , 2005, Blood.
[66] A. Rudensky,et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.
[67] A. Hanash,et al. Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. , 2005, Blood.
[68] J. Serody,et al. L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. , 2004, Blood.
[69] M. V. von Herrath,et al. Initiation of autoimmunity. , 2004, Current opinion in immunology.
[70] B. Levine,et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. , 2004, Blood.
[71] M. Shlomchik,et al. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. , 2004, Blood.
[72] B. Levine,et al. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. , 2004, Blood.
[73] R. Andreesen,et al. Large scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells , 2004, Cancer Cell International.
[74] Jeffrey A. Bluestone,et al. In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.
[75] O. Joffre,et al. Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. , 2004, Blood.
[76] Clare Baecher-Allan,et al. Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis , 2004, The Journal of experimental medicine.
[77] Li Li,et al. Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.
[78] D. Klatzmann,et al. Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. , 2003, The Journal of clinical investigation.
[79] T. Strom,et al. CD154 on the surface of CD4+CD25+ regulatory t cells contributes to skin transplant tolerance , 2003, Transplantation.
[80] J. Alcocer-Varela,et al. Quantification of regulatory T cells in patients with systemic lupus erythematosus. , 2003, Journal of autoimmunity.
[81] T. Hünig,et al. Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist , 2003, European journal of immunology.
[82] K. Wood,et al. Regulatory lymphocytes: Regulatory T cells in transplantation tolerance , 2003, Nature Reviews Immunology.
[83] T. Nomura,et al. Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .
[84] C. Fathman,et al. The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR71 , 2002, The Journal of Immunology.
[85] David Klatzmann,et al. CD4+CD25+ Immunoregulatory T Cells , 2002, The Journal of experimental medicine.
[86] C. Fathman,et al. Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation , 2002, The Journal of experimental medicine.
[87] Michael S. Kuhns,et al. CTLA-4: new insights into its biological function and use in tumor immunotherapy , 2002, Nature Immunology.
[88] A. Coutinho,et al. Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[89] B. Blazar,et al. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. , 2002, Blood.
[90] David F. Richards,et al. In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.
[91] T. Strom,et al. Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance1 , 2002, The Journal of Immunology.
[92] R. Noelle,et al. Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade , 2001, The Journal of experimental medicine.
[93] N. Sarvetnick,et al. CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection. , 1999, Journal of immunology.
[94] J. Lafaille,et al. Regulatory Cd4 Ϩ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis , 1998 .
[95] M. Toda,et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.
[96] B. Hall,et al. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action , 1990, The Journal of experimental medicine.
[97] Joseph Y. Halpern,et al. [Small-cell lung cancer]. , 1984, Harefuah.
[98] R. Gershon. A Disquisition on Suppressor T Cells , 1975, Transplantation reviews.
[99] C. Piccirillo. CD4 + Foxp3 + Regulatory T Cells in Immune Tolerance , 2008 .
[100] G. Galbraith. Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412Suntharalingam G, Perry MR, Ward S, et al (Northwick Park and St Mark's Hosp, London; Hammersmith Hosp, London; Imperial College, London) N Engl J Med 355:1018–1028, 2006§ , 2007 .
[101] Mark S. Anderson,et al. The NOD mouse: a model of immune dysregulation. , 2005, Annual review of immunology.
[102] C. June,et al. The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. , 2005, Blood.
[103] M. Peakman,et al. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. , 2005, Diabetes.
[104] Svetlana Ten,et al. Multiple immuno-regulatory defects in type-1 diabetes. , 2002, The Journal of clinical investigation.
[105] J. Kroepfl,et al. Myelin/Oligodendrocyte Glycoprotein , 1997 .
[106] A. Singer,et al. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. , 1992, Annual review of immunology.