GPR43/FFA2: physiopathological relevance and therapeutic prospects.
暂无分享,去创建一个
[1] Patrice D Cani,et al. Evaluation of the relationship between GPR43 and adiposity in human , 2013, Nutrition & Metabolism.
[2] B. Hudson,et al. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[3] W. D. de Vos,et al. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women , 2012, Gut.
[4] B. Hudson,et al. Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3* , 2012, The Journal of Biological Chemistry.
[5] T. Ulven. Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets , 2012, Front. Endocrin..
[6] O. Feron,et al. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver , 2012, British Journal of Cancer.
[7] S. Offermanns,et al. G protein-coupled receptors for energy metabolites as new therapeutic targets , 2012, Nature Reviews Drug Discovery.
[8] F. Duca,et al. Increased Oral Detection, but Decreased Intestinal Signaling for Fats in Mice Lacking Gut Microbiota , 2012, PloS one.
[9] Brian K Shoichet,et al. Structure-based drug screening for G-protein-coupled receptors. , 2012, Trends in pharmacological sciences.
[10] D. Donnelly,et al. The structure and function of the glucagon‐like peptide‐1 receptor and its ligands , 2012, British journal of pharmacology.
[11] A. M. Habib,et al. Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 , 2012, Diabetes.
[12] M. Gänzle,et al. Inulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic rats , 2012, British Journal of Nutrition.
[13] R. Curi,et al. Regulation of Inflammation by Short Chain Fatty Acids , 2011, Nutrients.
[14] Jacques Schrenzel,et al. Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice , 2011, Diabetes.
[15] J. Olefsky,et al. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. , 2011, Trends in pharmacological sciences.
[16] L. Deldicque,et al. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. , 2011, The Journal of nutritional biochemistry.
[17] Patrice D Cani,et al. Interaction between obesity and the gut microbiota: relevance in nutrition. , 2011, Annual review of nutrition.
[18] Leigh A. Stoddart,et al. Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator , 2011, Molecular Pharmacology.
[19] P. Hawkins,et al. SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor , 2011, PloS one.
[20] M. Noakes,et al. Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch. , 2011, The Journal of nutrition.
[21] D. Nie,et al. Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death , 2011, Cell Death and Differentiation.
[22] D. Nie,et al. G‐protein‐coupled receptor for short‐chain fatty acids suppresses colon cancer , 2011, International journal of cancer.
[23] R. Lindberg,et al. Mutational analysis of G-protein coupled receptor--FFA2. , 2011, Biochemical and biophysical research communications.
[24] I. Kaji,et al. Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide , 2011, Journal of Molecular Histology.
[25] J. Darzi,et al. Do SCFA have a role in appetite regulation? , 2011, Proceedings of the Nutrition Society.
[26] B. Hudson,et al. Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists , 2011, The Journal of Biological Chemistry.
[27] R. Lindberg,et al. Allosteric rescuing of loss‐of‐function FFAR2 mutations , 2010, FEBS letters.
[28] Nathalie M. Delzenne,et al. Prebiotic effects: metabolic and health benefits , 2010, British Journal of Nutrition.
[29] M. Cawthorne,et al. Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids , 2010, FEBS letters.
[30] P. Bork,et al. A human gut microbial gene catalogue established by metagenomic sequencing , 2010, Nature.
[31] T. Wolever,et al. The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. , 2010, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
[32] S. Wong,et al. The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators. , 2010, Bioorganic & medicinal chemistry letters.
[33] N. Sata,et al. Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening , 2010, Cancer science.
[34] F. Monsma,et al. Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines. , 2009 .
[35] R. Xavier,et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 , 2009, Nature.
[36] T. Wolever,et al. Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α , 2009, British Journal of Nutrition.
[37] I. Rowland. The role of the gastrointestinal microbiota in colorectal cancer. , 2009, Current pharmaceutical design.
[38] T. van de Wiele,et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability , 2009, Gut.
[39] Leigh A. Stoddart,et al. International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions , 2008, Pharmacological Reviews.
[40] Yang Li,et al. Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2 , 2008, Molecular Pharmacology.
[41] Leigh A. Stoddart,et al. Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids* , 2008, Journal of Biological Chemistry.
[42] Masashi Yanagisawa,et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 , 2008, Proceedings of the National Academy of Sciences.
[43] Yang Li,et al. Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. , 2008, Endocrinology.
[44] I. Kaji,et al. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. , 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[45] S. Karaki,et al. Expression of the short-chain fatty acid receptor, GPR43, in the human colon , 2008, Journal of Molecular Histology.
[46] C. Knauf,et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia , 2007, Diabetologia.
[47] W. Shehee,et al. The relationship between the effects of short‐chain fatty acids on intestinal motility in vitro and GPR43 receptor activation , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
[48] T. Iwanaga,et al. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine , 2006, Cell and Tissue Research.
[49] Ki-Choon Choi,et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. , 2005, Endocrinology.
[50] R. Kedzierski,et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[51] Darrell R. Abernethy,et al. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels , 2003, Pharmacological Reviews.
[52] M. Parmentier,et al. Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation* , 2003, Journal of Biological Chemistry.
[53] B. Olde,et al. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. , 2003, Biochemical and biophysical research communications.
[54] S. Dowell,et al. The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids* , 2003, The Journal of Biological Chemistry.
[55] J. Galmiche,et al. Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression , 2000, Gut.
[56] E. Anderson. Hudson et al. , 1977 .
[57] B. Hudson,et al. Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors. , 2011, Advances in pharmacology.
[58] M. Bohlooly-y,et al. Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. , 2011, American journal of physiology. Endocrinology and metabolism.
[59] P. Rosenstiel,et al. Inflammationfor Neutrophil Recruitment during Intestinal G Protein-Coupled Receptor 43 Is Essential , 2009 .