Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

[1]  C. Mackay,et al.  Diet, metabolites, and "western-lifestyle" inflammatory diseases. , 2014, Immunity.

[2]  Huidong Shi,et al.  Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. , 2014, Immunity.

[3]  C. Mackay,et al.  The role of short-chain fatty acids in health and disease. , 2014, Advances in immunology.

[4]  M. Tomita,et al.  Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells , 2013, Nature.

[5]  A. Rudensky,et al.  Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation , 2013, Nature.

[6]  W. Garrett,et al.  The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis , 2013, Science.

[7]  Omry Koren,et al.  AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition , 2013, Gut.

[8]  T. Schwartz,et al.  GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. , 2013, Endocrinology.

[9]  G. Núñez,et al.  K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. , 2013, Immunity.

[10]  S. Akira,et al.  Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance. , 2013, Biochimica et biophysica acta.

[11]  S. Shabala,et al.  Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx , 2012, Cell biochemistry and function.

[12]  E. Latz,et al.  The Inflammasome , 2013, Methods in Molecular Biology.

[13]  Belgin Dogan,et al.  Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota , 2012, Science.

[14]  Jiujiu Yu,et al.  Critical role for calcium mobilization in activation of the NLRP3 inflammasome , 2012, Proceedings of the National Academy of Sciences.

[15]  Robert W. Williams,et al.  Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits , 2012, PloS one.

[16]  J. Clemente,et al.  The Impact of the Gut Microbiota on Human Health: An Integrative View , 2012, Cell.

[17]  Richard A. Flavell,et al.  Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.

[18]  F. Bushman,et al.  Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes , 2011, Science.

[19]  Yikyung Park,et al.  Dietary fiber intake and mortality in the NIH-AARP diet and health study. , 2011, Archives of internal medicine.

[20]  J. Gordon,et al.  Human nutrition, the gut microbiome and the immune system , 2011, Nature.

[21]  Yan Li,et al.  NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis , 2011, Inflammatory bowel diseases.

[22]  Richard A. Flavell,et al.  NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis , 2011, Cell.

[23]  M. Chamaillard,et al.  Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury , 2011, Proceedings of the National Academy of Sciences.

[24]  M. Hattori,et al.  Bifidobacteria can protect from enteropathogenic infection through production of acetate , 2011, Nature.

[25]  S. Massart,et al.  Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa , 2010, Proceedings of the National Academy of Sciences.

[26]  M. Kastan,et al.  The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. , 2010, Immunity.

[27]  N. Beauchemin,et al.  Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. , 2010, Immunity.

[28]  A. Macpherson,et al.  Immune adaptations that maintain homeostasis with the intestinal microbiota , 2010, Nature Reviews Immunology.

[29]  S. Duncan,et al.  The Induction of Colitis and Ileitis in Mice Is Associated with Marked Increases in Intestinal Concentrations of Stimulants of TLRs 2, 4, and 5 , 2010, PloS one.

[30]  C. Mackay,et al.  Diet, gut microbiota and immune responses , 2010, Nature Immunology.

[31]  R. Knight,et al.  The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice , 2009, Science Translational Medicine.

[32]  R. Xavier,et al.  Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 , 2009, Nature.

[33]  G. Núñez,et al.  Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation1 , 2009, The Journal of Immunology.

[34]  Pat Baird,et al.  Health benefits of dietary fiber. , 2009, Nutrition reviews.

[35]  G. Cresci,et al.  GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. , 2009, Cancer research.

[36]  Doris M Jacobs,et al.  Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics. , 2009, Current drug metabolism.

[37]  H. Flint,et al.  Human colonic microbiota associated with diet, obesity and weight loss , 2008, International Journal of Obesity.

[38]  R. Ley,et al.  Innate immunity and intestinal microbiota in the development of Type 1 diabetes , 2008, Nature.

[39]  Takuya Suzuki,et al.  Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability , 2008, British Journal of Nutrition.

[40]  L. Fulton,et al.  Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. , 2008, Cell host & microbe.

[41]  M. Fey,et al.  Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A) , 2008, Cell Death and Differentiation.

[42]  D. Connolly,et al.  (d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G* , 2005, Journal of Biological Chemistry.

[43]  A. Zarzuelo,et al.  Effects of dietary fiber on inflammatory bowel disease. , 2005, Molecular nutrition & food research.

[44]  Ruslan Medzhitov,et al.  Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis , 2004, Cell.

[45]  M. Parmentier,et al.  Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation* , 2003, Journal of Biological Chemistry.

[46]  S. Tunaru,et al.  PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect , 2003, Nature Medicine.

[47]  T. Hibi,et al.  Dietary fiber fraction of germinated barley foodstuff attenuated mucosal damage and diarrhea, and accelerated the repair of the colonic mucosa in an experimental colitis , 2001, Journal of gastroenterology and hepatology.

[48]  G. Spindler,et al.  An Integrative View , 1992 .

[49]  P. Negulescu,et al.  Carbachol-activated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume. , 1992, Proceedings of the National Academy of Sciences of the United States of America.