Clearance of Particles Deposited in the Lungs

[1]  W Stahlhofen,et al.  Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. , 1980, American Industrial Hygiene Association journal.

[2]  B. Muggenburg,et al.  The role of macrophages in particle translocation from lungs to lymph nodes. , 1985, Science.

[3]  P. Gallé,et al.  Role of alveolar macrophages in precipitation of mineral elements inhaled as soluble aerosols. , 1992, Environmental health perspectives.

[4]  A. Brody,et al.  Pulmonary macrophages are attracted to inhaled particles through complement activation. , 1988, Experimental lung research.

[5]  D. Luchtel.  Mucociliary interactions in rabbit intrapulmonary airways. , 1982, Progress in clinical and biological research.

[6]  A. Churg,et al.  Association of lung cancer and airway particle concentration. , 1988, Environmental research.

[7]  P. Morrow,et al.  Possible mechanisms to explain dust overloading of the lungs. , 1988, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[8]  W. Foster,et al.  Supramicron-sized particle clearance from alveoli: route and kinetics. , 1990, Journal of applied physiology.

[9]  E. Weibel,et al.  Extracellular lining of bronchioles after perfusion‐fixation of rat lungs for electron microscopy , 1971, The Anatomical record.

[10]  E. Marafante,et al.  Dissolution of two arsenic compounds by rabbit alveolar macrophages in vitro. , 1987, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[11]  M. R. Bailey,et al.  Respiratory tract retention of relatively insoluble particles in rodents , 1985 .

[12]  G. Oberdörster,et al.  Lung Dosimetry: Pulmonary Clearance of Inhaled Particles , 1993 .

[13]  H. Métivier,et al.  In vitro dissolution of uranium oxide by baboon alveolar macrophages. , 1992, Environmental health perspectives.

[14]  P. Morrow,et al.  Association of 59iron oxide with alveolar macrophages during alveolar clearance. , 1985, Experimental lung research.

[15]  H. Muhle,et al.  Overloading of Lung Clearance During Chronic Exposure of Experimental Animals to Particles , 1988 .

[16]  A. James,et al.  The Effect of Alpha Irradiation on Retention of Particles in the Rat Lung , 1988 .

[17]  A. Bailey,et al.  Human Bronchiolar Deposition and Retention of 6-, 8-, and 10-µm Particles , 1997 .

[18]  M. R. Bailey,et al.  Measurement of the Tracheobronchial Clearance of Particles after Aerosol Bolus Inhalation , 1994 .

[19]  A. Hilding,et al.  Ciliary streaming in the lower respiratory tract. , 1957, The American journal of physiology.

[20]  J. Brain,et al.  Lung macrophages: how many kinds are there? What do they do? , 1988, The American review of respiratory disease.

[21]  Y Ikada,et al.  Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage. , 1988, Biomaterials.

[22]  W. Foster,et al.  Determining deposition sites of inhaled lung particles and their effect on clearance. , 1990, Journal of applied physiology.

[23]  R. McClellan,et al.  Retention and distribution of 244 Cm following inhalation of 244 CmCl 3 and 244 CmO 1.73 by beagle dogs. , 1971, Health physics.

[24]  W. Kreyling,et al.  Particle Transport from the Lower Respiratory Tract , 1987 .

[25]  H. Ayhan,et al.  Phagocytosis of monosize polystyrene-based microspheres having different size and surface properties. , 1995, Journal of biomaterials science. Polymer edition.

[26]  Gerhard Scheuch,et al.  Measurement of lung clearance with pulses of radioactively-labelled aerosols , 1986 .

[27]  W. Kreyling,et al.  Metabolic fate of inhaled Co aerosols in beagle dogs. , 1986, Health physics.

[28]  M. Feldstein,et al.  Pulmonary clearance and hilar lymph node content in rats after particle exposure. , 1978, Environmental research.

[29]  Marianne Geiser,et al.  The Fate of Particles Deposited in the Intrapulmonary Conducting Airways , 1991 .

[30]  P Camner,et al.  Estimation of pH in individual alveolar macrophage phagolysosomes. , 1989, Experimental lung research.

[31]  R. Frank,et al.  Alveolar macrophage adhesion: wash electrolyte composition and free cell yield. , 1973, Journal of applied physiology.

[32]  H. Métivier,et al.  Beryllium Metal Solubility in the Lung, Comparison of Metal and Hot-pressed Forms by in vivo and in vitro Dissolution Bioassays , 1987, Human toxicology.

[33]  W. Foster,et al.  Lung mucociliary function in man: interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjects. , 1982, The Annals of occupational hygiene.

[34]  R. McClellan,et al.  Retention of monodisperse or polydisperse aluminosilicate particles inhaled by dogs, rats, and mice. , 1983, Toxicology and applied pharmacology.

[35]  M. R. Bailey,et al.  Investigations of Retention of Inhaled Particles in the Human Bronchial Tree , 1995 .

[36]  H. Métivier,et al.  Interspecies comparison of lung clearance after inhalation of monodisperse, solid cobalt oxide aerosol particles , 1989 .

[37]  R. Schlesinger,et al.  Clearance from the respiratory tract. , 1985, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[38]  L. Kobzik,et al.  Selective down-regulation of alveolar macrophage oxidative response to opsonin-independent phagocytosis. , 1990, Journal of immunology.

[39]  J. C. Lay,et al.  Pulmonary clearance of inhaled particles 24 to 48 hours post deposition: Effect of beta-adrenergic stimulation , 1993 .

[40]  M. Svartengren,et al.  Tracheobronchial deposition and clearance in small airways in asthmatic subjects. , 1996, The European respiratory journal.

[41]  R. Kraft,et al.  Accumulation of anthracotic particles along lymphatics of the human lung: Relevance to “hot spot” formation after inhalation of poorly soluble radionuclides , 1987, Radiation and environmental biophysics.

[42]  L. J. Leach,et al.  The Clearance of Uranium Dioxide Dust from the Lungs Following Single and Multiple Inhalation Exposures , 1966 .

[43]  W. Kreyling,et al.  Intraphagolysosomal pH in canine and rat alveolar macrophages: flow cytometric measurements. , 1992, Environmental health perspectives.

[44]  B. Lehnert,et al.  Alveolar macrophage-particle relationships during lung clearance. , 1989, American journal of respiratory cell and molecular biology.

[45]  C. Stirling,et al.  The retention of particles in large airways of the respiratory tract , 1977, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[46]  G. Oberdörster,et al.  Pulmonary retention of ultrafine and fine particles in rats. , 1992, American journal of respiratory cell and molecular biology.

[47]  W G Kreyling,et al.  Lung clearance in Long-Evans rats after inhalation of porous, monodisperse cobalt oxide particles. , 1993, Experimental lung research.

[48]  W. Kreyling,et al.  Intracellular particle dissolution in macrophages isolated from the lung of the Fischer (F-344) rat. , 1994, Experimental lung research.

[49]  A. Eklund,et al.  Dissolution of metals by human and rabbit alveolar macrophages. , 1985, British journal of industrial medicine.

[50]  P. Morrow,et al.  An analysis of alveolar macrophage mobility kinetics at dust overloading of the lungs. , 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[51]  E. Ansoborlo,et al.  In vitro chemical and cellular tests applied to uranium trioxide with different hydration states. , 1992, Environmental Health Perspectives.

[52]  Marianne Geiser,et al.  Particle Retention in Airways by Surfactant , 1990 .

[53]  P. Camner,et al.  Intraphagosomal pH in alveolar macrophages studied with fluorescein-labeled amorphous silica particles. , 1989, Experimental lung research.

[54]  J. Brain,et al.  Pathways of clearance in mouse lungs exposed to iron oxide aerosols , 1975, The Anatomical record.

[55]  B. Lehnert,et al.  Migratory behaviors of alveolar macrophages during the alveolar clearance of light to heavy burdens of particles. , 1990, Experimental lung research.

[56]  W. Foster.  Editorial Is 24 Hour Lung Retention an Index of Alveolar Deposition , 1988 .

[57]  W. Kreyling.  Aerosol particle parameters maintaining lung clearance by intracellular dissolution and translocation , 1990 .

[58]  M. Svartengren,et al.  Clearance of particles from small ciliated airways. , 1997, Experimental lung research.

[59]  A. Hodgson,et al.  Labeling Rat Alveolar Macrophages with Fluorescent Microspheres , 1995 .

[60]  K. Philipson,et al.  Long-term lung clearance of 195Au-labeled teflon particles in humans. , 1996, Experimental lung research.

[61]  L. Cruz-Orive,et al.  Histological and Stereological Analysis of Particle Retention in the Conducting Airways of Hamster Lungs , 1990 .

[62]  W. G. Kreyling,et al.  Interspecies Comparison of Lung Clearance of "Insoluble" Particles , 1990 .

[63]  Günter Oberdörster,et al.  Lung Clearance of Inhaled Insoluble and Soluble Particles , 1988 .

[64]  Marianne Geiser,et al.  Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator 1 , 1990, Journal of microscopy.

[65]  J. F. Park,et al.  Comparison of early mortality in baboons and dogs after inhalation of 239PuO2. , 1980, Radiation research.

[66]  N. Gillett,et al.  Translocation of Particles by Macrophages from Lung to Lymph Nodes in Rats , 1989 .

[67]  G. J. Newton,et al.  Cobalt-60 oxide aerosols: methods of production and short-term retention and distribution kinetics in the beagle dog. , 1976, Health physics.

[68]  Mewhinney Ja,et al.  Models of Am metabolism in beagles and humans. , 1982 .

[69]  J. Brain,et al.  Retention and clearance of 0.9-micron particles inhaled by hamsters during rest or exercise. , 1991, Journal of applied physiology.

[70]  D H Bowden,et al.  Adaptive responses of the pulmonary macrophagic system to carbon. II. Morphologic studies. , 1978, Laboratory investigation; a journal of technical methods and pathology.

[71]  T. Ahmed,et al.  Variability of hypoxic pulmonary vasoconstriction in sheep. Role of prostaglandins. , 2015, The American review of respiratory disease.

[72]  J. Steinkamp,et al.  Airway intra-luminal macrophages: evidence of origin and comparisons to alveolar macrophages. , 1990, American journal of respiratory cell and molecular biology.

[73]  S. Goodman,et al.  Effect of size, concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in vitro. , 1996, Journal of biomedical materials research.

[74]  Morton Lippmann,et al.  32 O 02 Aerosol recovery after bolus inhalations into an airway cast , 1993 .

[75]  G Scheuch,et al.  An approach to deposition and clearance measurements in human airways. , 1996, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[76]  Robert G. Thomas.  TRANSPORT OF RELATIVELY INSOLUBLE MATERIALS FROM LUNG TO LYMPH NODES. , 1968 .

[77]  T. Isawa,et al.  Mucociliary clearance mechanism in smoking and nonsmoking normal subjects. , 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[78]  R. Cuddihy,et al.  Inhalation exposures of beagle dogs to cerium aerosols: physical, chemical and mathematical analysis. , 1975, Health physics.

[79]  A Hodgson,et al.  Effect of bronchopulmonary lavage on lung retention and clearance of particulate material in hamsters. , 1992, Environmental health perspectives.

[80]  L. Leak.  Lymphatic removal of fluids and particles in the mammalian lung. , 1980, Environmental health perspectives.

[81]  S. Schürch,et al.  Surfactant displaces particles toward the epithelium in airways and alveoli. , 1990, Respiration physiology.

[82]  J. Heyder,et al.  Intercomparison of regional deposition of aerosol particles in the human respiratory tract and their long-term elimination. , 1981, Experimental lung research.

[83]  W. Kreyling,et al.  Interspecies Comparison of Phagolysosomal pH in Alveolar Macrophages , 1991 .

[84]  D. Bohning,et al.  Bronchial deposition and clearance of aerosols. , 1973, Archives of internal medicine.

[85]  P. Camner,et al.  Ability of rabbit alveolar macrophages to dissolve metals. , 1984, Experimental lung research.

[86]  M. Svartengren,et al.  Human deposition and clearance of 6-micron particles inhaled with an extremely low flow rate. , 1995, Experimental lung research.

[87]  H. Ohshima,et al.  Effect of particle size on phagocytosis of latex particles by guinea-pig polymorphonuclear leucocytes. , 1991, Journal of biomaterials science. Polymer edition.

[88]  Icrp.  Human Respiratory Tract Model for Radiological Protection , 1994 .

[89]  S. Takenaka,et al.  Alveolar distribution of fly ash and of titanium dioxide after long-term inhalation by Wistar rats , 1986 .

[90]  E. Lorenz.  Radioactivity and Lung Cancer; A Critical Review of Lung Cancer in the Miners of Schneeberg and Joachimsthal , 1944 .

[91]  W G Kreyling,et al.  In vitro dissolution of uniform cobalt oxide particles by human and canine alveolar macrophages. , 1990, American journal of respiratory cell and molecular biology.

[92]  W. Bennett,et al.  Cough-enhanced mucus clearance in the normal lung. , 1990, Journal of applied physiology.

[93]  C. Cox,et al.  Intratracheal instillation versus intratracheal-inhalation of tracer particles for measuring lung clearance function. , 1997, Experimental lung research.

[94]  B. Lehnert,et al.  Mechanisms Underlying the "Particle Redistribution Phenomenon" , 1992 .

[95]  A. van As,et al.  Mucus transport in the tracheobronchial tree of normal and bronchitic rats , 1972, The Journal of pathology.

[96]  B. Muggenburg,et al.  Migration of Neutrophils From Lung to Tracheobronchial Lymph Node , 1987, Journal of leukocyte biology.

[97]  M. R. Bailey,et al.  An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles—Part V: Lung clearance of inhaled cobalt oxide particles in hamsters, rats and guinea-pigs , 1989 .

[98]  Robert Gelein,et al.  Pulmonary Tissue Access of Ultrafine Particles , 1991 .

[99]  Robert Gelein,et al.  Increased pulmonary toxicity of ultrafine particles? I. Particle clearance, translocation, morphology , 1990 .

[100]  R. Perry,et al.  Interpretation of "24 Hour Lung Retention" in Studies of Mucociliary Clearance , 1988 .

[101]  B. Lehnert,et al.  Translocation of particles to the tracheobronchial lymph nodes after lung deposition: kinetics and particle-cell relationships. , 1986, Experimental lung research.

[102]  C. Garrard,et al.  Characteristics of tracheobronchial deposition and clearance in man. , 1982, The Annals of occupational hygiene.

[103]  Shinji Takenaka,et al.  Early Response of the Canine Respiratory Tract Following Long-Term Exposure to a Sulfur(IV) Aerosol at low Concentration. III. Macrophage-Mediated Long-Term Particle Clearance , 1992 .

[104]  Mercer Tt.  On the role of particle size in the dissolution of lung burdens. , 1967 .

[105]  P. Morrow,et al.  Reversibility of clearance impairment after subchronic test toner inhalation. , 1989, Experimental pathology.

[106]  Cuddihy Rg,et al.  A biological model describing tissue distribution and whole-body retention of barium and lanthanum in beagle dogs after inhalation and gavage. , 1972 .

[107]  M. R. Bailey,et al.  An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles - part I: objectives and summary of results , 1989 .

[108]  J. A. Mewhinney,et al.  The influence of aerosol size on retention and translocation of 241Am following inhalation of 241AmO2 by beagles. , 1982, Health physics.

[109]  W. Kreyling,et al.  An interspecies comparison of the lung clearance of inhaled monodisperse cobalt oxide particles—Part IV: Lung clearance of inhaled cobalt oxide particles in Beagle dogs , 1989 .

[110]  R. Snyderman,et al.  Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. , 1985, Laboratory investigation; a journal of technical methods and pathology.

[111]  G. Patrick,et al.  The localisation of particles retained in the trachea of the rat , 1980, The Journal of pathology.

[112]  P. Camner,et al.  Phagolysosomal pH in alveolar macrophages. , 1992, Environmental health perspectives.

[113]  M. Clem,et al.  Retention of microspheres in the rat lung after intratracheal instillation. , 1981, Environmental research.