Extinction in Human Fear Conditioning

Although most extinction research is conducted in animal laboratories, the study of extinction learning in human fear conditioning has gained increasing attention over the last decade. The most important findings from human fear extinction are reviewed in this article. Specifically, we review experimental investigations of the impact of conditioned inhibitors, conditioned exciters, context renewal, and reinstatement on fear extinction in human samples. We discuss data from laboratory studies of the extinction of aversively conditioned stimuli, as well as results from experimental clinical work with fearful or anxious individuals. We present directions for future research, in particular the need for further investigation of differences between animal and human conditioning outcomes, and research examining the role of both automatic and higher-order cognitive processes in human conditioning and extinction.

[1]  M. Craske,et al.  Mental reinstatement of context and return of fear in spider-fearful participants. , 2006, Behavior therapy.

[2]  S. Mineka,et al.  A modern learning theory perspective on the etiology of panic disorder. , 2001, Psychological review.

[3]  S. Klein,et al.  Handbook of contemporary learning theories , 2000 .

[4]  B. Vervliet,et al.  Generalization of extinguished skin conductance responding in human fear conditioning. , 2004, Learning & memory.

[5]  P. Salkovskis The Importance of Behaviour in the Maintenance of Anxiety and Panic: A Cognitive Account , 1991, Behavioural Psychotherapy.

[6]  M. Craske,et al.  Treatment context and return of fear in spider phobia , 2002 .

[7]  Bram Vervliet,et al.  Return of fear in a human differential conditioning paradigm caused by a stimulus change after extinction. , 2005, Behaviour research and therapy.

[8]  P. Lelliott,et al.  Alprazolam and Exposure Alone and Combined in Panic Disorder with Agoraphobia , 1993, British Journal of Psychiatry.

[9]  Joseph E LeDoux,et al.  Extinction Learning in Humans Role of the Amygdala and vmPFC , 2004, Neuron.

[10]  G. Crombez,et al.  Does imminent threat capture and hold attention? , 2004, Emotion.

[11]  Mark E. Bouton,et al.  Sources of relapse after extinction in Pavlovian and instrumental learning , 1991 .

[12]  D. Tolin,et al.  Disgust and disgust sensitivity in blood-injection-injury and spider phobia. , 1997, Behaviour research and therapy.

[13]  Steven M. Smith Remembering In and Out of Context , 1979 .

[14]  M. Bouton,et al.  Analysis of the associative and occasion-setting properties of contexts participating in a Pavlovian discrimination. , 1986 .

[15]  Laura L. Vernon,et al.  Changes in caffeine states enhance return of fear in spider phobia. , 2003, Journal of consulting and clinical psychology.

[16]  R. Richardson,et al.  Reinstatement of fear to an extinguished conditioned context , 1999 .

[17]  T. Nicholas,et al.  Blocking of inhibitory conditioning within a serial conditioned stimulus-conditioned inhibitor compound: Maintenance of acquired behavior without an unconditioned stimulus , 1983 .

[18]  A. Field,et al.  Associative learning of likes and dislikes , 2005 .

[19]  W. O’Donohue Learning and Behavior Therapy , 1997 .

[20]  D. Hermans,et al.  Reinstatement of extinguished conditioned responses and negative stimulus valence as a pathway to return of fear in humans. , 2004, Learning & memory.

[21]  P. Lovibond,et al.  Protection from extinction in human fear conditioning. , 2000, Behaviour research and therapy.

[22]  M. Dawson,et al.  Allocation of cognitive processing capacity during human autonomic classical conditioning. , 1982, Journal of experimental psychology. General.

[23]  Extinction: A review of theory and the evidence suggesting that memories are not erased with nonreinforcement. , 1998 .

[24]  R. Rescorla Protection from extinction , 2003, Learning & behavior.

[25]  Andy J. Wills,et al.  New Directions in Human Associative Learning , 2005 .

[26]  A. Delamater THE QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 2004, 57B (2), 97–132 Experimental extinction in Pavlovian , 2022 .

[27]  G. Crombez,et al.  Expectancy-learning and evaluative learning in human classical conditioning: affective priming as an indirect and unobtrusive measure of conditioned stimulus valence. , 2002, Behaviour research and therapy.

[28]  Elliot A. Stein,et al.  Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning , 2007 .

[29]  L. Michelson,et al.  Chronic life stress and treatment outcome in agoraphobia with panic attacks. , 1993, The American journal of psychiatry.

[30]  Christopher J. Mitchell,et al.  Backward and forward Blocking in Human Electrodermal Conditioning: Blocking Requires an Assumption of Outcome Additivity , 2002, The Quarterly journal of experimental psychology. B, Comparative and physiological psychology.

[31]  K. Mogg,et al.  Emotional conditioning to masked stimuli and modulation of visuospatial attention. , 2005, Emotion.

[32]  O. Lipp,et al.  No support for dual process accounts of human affective learning in simple Pavlovian conditioning , 2005, Cognition & emotion.

[33]  I. Pavlov,et al.  Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex. , 1929, Annals of neurosciences.

[34]  M. Bouton,et al.  A retrieval cue for extinction attenuates response recovery (renewal) caused by a return to the conditioning context. , 1994 .

[35]  Michael Davis,et al.  Behavioral and Neural Analysis of Extinction , 2002, Neuron.

[36]  T. Beckers,et al.  Return of fear in a human differential conditioning paradigm caused by a return to the original acquistion context. , 2005, Behaviour research and therapy.

[37]  P. Lovibond Causal beliefs and conditioned responses: retrospective revaluation induced by experience and by instruction. , 2003, Journal of experimental psychology. Learning, memory, and cognition.

[38]  M. Telch,et al.  The effects of safety-seeking behavior and guided threat reappraisal on fear reduction during exposure: an experimental investigation. , 2002, Behaviour research and therapy.

[39]  M. Bradley,et al.  Emotion, attention, and the startle reflex. , 1990, Psychological review.

[40]  Barbara O Rothbaum,et al.  Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. , 2004, Archives of general psychiatry.

[41]  S. Rauch,et al.  Context modulation of memory for fear extinction in humans. , 2005, Psychophysiology.

[42]  J. Gore,et al.  Activation of the left amygdala to a cognitive representation of fear , 2001, Nature Neuroscience.

[43]  S. Mineka,et al.  Context-specificity of relapse: effects of therapist and environmental context on return of fear. , 1999, Behaviour research and therapy.

[44]  S. Mineka,et al.  Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. , 2001, Psychological review.

[45]  O. Van den Bergh,et al.  Reinstatement of fear responses in human aversive conditioning. , 2005, Behaviour research and therapy.

[46]  Mark B Powers,et al.  Disentangling the effects of safety-behavior utilization and safety-behavior availability during exposure-based treatment: a placebo-controlled trial. , 2004, Journal of consulting and clinical psychology.

[47]  R. Rescorla,et al.  Reinstatement of fear to an extinguished conditioned stimulus. , 1975, Journal of experimental psychology. Animal behavior processes.

[48]  Effects of miscuing on pavlovian conditioned responding and on probe reaction time , 1993 .

[49]  G. Crombez,et al.  Expectancy-learning and evaluative learning in human classical conditioning: differential effects of extinction , 2003 .

[50]  D. Shanks,et al.  The role of awareness in Pavlovian conditioning: empirical evidence and theoretical implications. , 2002, Journal of experimental psychology. Animal behavior processes.

[51]  M. Bouton,et al.  Context and ambiguity in the extinction of emotional learning: implications for exposure therapy. , 1988, Behaviour research and therapy.

[52]  G. Davey,et al.  A test of a disease-avoidance model of animal phobias. , 1991, Behaviour research and therapy.

[53]  M. Bouton Context, Ambiguity, and Classical Conditioning , 1994 .

[54]  E. Phelps,et al.  Reinstatement of conditioned fear in humans is context dependent and impaired in amnesia. , 2005, Behavioral neuroscience.

[55]  C. Koch,et al.  Working memory and fear conditioning , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[56]  A. Columbus Advances in Psychology Research , 2005 .

[57]  Erik W. Moody,et al.  Counteracting the Context-Dependence of Extinction: Relapse and Tests of Some Relapse Prevention Methods. , 2006 .

[58]  M. Bouton,et al.  Time and context effects on performance in a Pavlovian discrimination reversal , 1993 .

[59]  Effects of extinction context and retrieval cues on alcohol cue reactivity among nonalcoholic drinkers. , 2002 .

[60]  G. Steketee Social Support and Treatment Outcome of Obsessive Compulsive Disorder at 9-Month Follow-up , 1993, Behavioural Psychotherapy.

[61]  Joseph E LeDoux,et al.  Human Amygdala Activation during Conditioned Fear Acquisition and Extinction: a Mixed-Trial fMRI Study , 1998, Neuron.

[62]  D. Hermans,et al.  Learning Perspectives on Anxiety Disorders , 2001 .

[63]  Lisa M. Shin,et al.  Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future , 2006, Biological Psychiatry.

[64]  R. Rescorla,et al.  A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement , 1972 .

[65]  A. Delamater Effects of several extinction treatments upon the integrity of Pavlovian stimulus-outcome associations , 1996 .

[66]  P. Lachenbruch Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[67]  P. Lovibond Cognitive processes in extinction. , 2004, Learning & memory.

[68]  B. Vervliet,et al.  Renewal and reinstatement of fear: Evidence from human conditioning research , 2006 .

[69]  Justin A. Harris,et al.  Reinstatement of fear to an extinguished conditioned stimulus: two roles for context. , 2002, Journal of experimental psychology. Animal behavior processes.

[70]  S. Mineka Animal Models of Anxiety-Based Disorders , 2019, Anxiety and the Anxiety Disorders.

[71]  S. Mineka,et al.  The effects of changing contexts on return of fear following exposure therapy for spider fear. , 1999, Journal of consulting and clinical psychology.

[72]  M. Craske,et al.  Fear and learning: From basic processes to clinical implications. , 2006 .

[73]  M. Bouton Context and behavioral processes in extinction. , 2004, Learning & memory.

[74]  J. Ayres,et al.  Use of the ABA fear renewal paradigm to assess the effects of extinction with co-present fear inhibitors or excitors: Implications for theories of extinction and for treating human fears and phobias , 2004 .

[75]  T. Beckers,et al.  On the role of controlled cognitive processes in human associative learning. , 2005 .

[76]  J. Maser,et al.  Anxiety and the Anxiety Disorders , 2019 .

[77]  M. Bouton,et al.  Renewal of extinguished responding in a second context , 1994 .

[78]  J. de Houwer,et al.  Associative learning of likes and dislikes: a review of 25 years of research on human evaluative conditioning. , 2001, Psychological bulletin.

[79]  R. Rescorla Extinction can be enhanced by a concurrent excitor. , 2000, Journal of experimental psychology. Animal behavior processes.

[80]  P. Salkovskis,et al.  Social Phobia: The Role of In-Situation Safety Behaviors in Maintaining Anxiety and Negative Beliefs , 1995 .

[81]  R. Clark,et al.  Classical conditioning and brain systems: the role of awareness. , 1998, Science.