论文信息 - A very potent factor V inhibitor interferes with the levels of all coagulation factors and causes a fatal hemorrhagic syndrome

A very potent factor V inhibitor interferes with the levels of all coagulation factors and causes a fatal hemorrhagic syndrome

We report a very high factor V inhibitor affecting the measurement of all coagulation factors besides fibrinogen, all these factors being dramatically decreased. This inhibitor could be linked to antibiotic use. The patient died of massive hemorrhage before a plasma exchange could be initiated.

[1] G. Lippi,et al. Acquired factor V inhibitors: a systematic review , 2011, Journal of Thrombosis and Thrombolysis.

[2] D. Peetz,et al. Massive Blutungsneigung bei zwei Patienten mit Faktor-V-Hemmkörper und Anti-Phospholipid-Antikörpern nach Ciprofloxacin-Einnahme , 2003, Medizinische Klinik.

[3] J. Zehnder,et al. Development of antibodies to thrombin and factor V with recurrent bleeding in a patient exposed to topical bovine thrombin. , 1990, Blood.

[4] H. Glueck,et al. Hemorrhagic death associated with a high titer factor V inhibitor , 1978, American journal of hematology.

[5] S. Stenbjerg,et al. A circulating factor V inhibitor: possible side effect of treatment with streptomycin. , 2009, Scandinavian journal of haematology.