A case of oral multiple primary carcinoma and a review of the Japanese literature of oral multiple primary carcinoma

We report a case of oral multiple carcinoma in a 59-year-old female. The first squamous cell carcinoma had grown on the right side upper molar region. We treated this carcinoma with operation and radiation therapy.Fourteen months after discharge, the second squamous cell carcinoma grew on the right side of under molar gingival region and this carcinoma was also excised under general anesthesia. No recurrence was seen at seventeen months follow up study.In addition, we reviewed the Japanese literature of oral multiple primary carcinoma from 1979 to 1990. 25 cases were reported and the most common histological type of neoplasms (98.5%) were squamous cell carcinoma. The ratio of males to females was about 2.1: 1. Both first and second carcinoma were most frequently found in tongues. The causes of oral multiple carcinoma such as radiation injury of oral mucous membrane at the radiation therapy to the first oral cancer were discussed.