Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling
暂无分享,去创建一个
[1] Yong Chen,et al. Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination , 2013, Proceedings of the National Academy of Sciences.
[2] R. Xavier,et al. Cutting Edge: Cell-Autonomous Control of IL-7 Response Revealed in a Novel Stage of Precursor B Cells , 2013, The Journal of Immunology.
[3] J. Manis,et al. Focal Adhesion Kinase Regulates the Localization and Retention of Pro-B Cells in Bone Marrow Microenvironments , 2013, The Journal of Immunology.
[4] R. Rickert,et al. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression , 2012, The Journal of experimental medicine.
[5] P. Ward,et al. Signaling in control of cell growth and metabolism. , 2012, Cold Spring Harbor perspectives in biology.
[6] Y. Kluger,et al. IL-7 Functionally Segregates the Pro-B Cell Stage by Regulating Transcription of Recombination Mediators across Cell Cycle , 2012, The Journal of Immunology.
[7] N. Minato,et al. E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin κ Locus , 2012, The Journal of Immunology.
[8] C. Paige,et al. The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation. , 2012, Seminars in immunology.
[9] H. D. Liggitt,et al. Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. , 2012, Immunity.
[10] R. Plenge,et al. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. , 2012, Immunity.
[11] E. Liu,et al. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. , 2012, Genes & development.
[12] Chi V Dang,et al. MYC on the Path to Cancer , 2012, Cell.
[13] R. Deberardinis,et al. Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? , 2012, Cell.
[14] Markus Werner,et al. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination , 2012, The Journal of experimental medicine.
[15] É. Vivier,et al. NK cell genesis: a trick of the trail. , 2012, Immunity.
[16] E. Bertolino,et al. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation , 2012, Nature Immunology.
[17] M. Schlissel,et al. RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferation , 2012, The Journal of experimental medicine.
[18] A. Dinner,et al. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2 , 2011, Nature Immunology.
[19] K. Rajewsky,et al. Efficient generation of B lymphocytes by recognition of self‐antigens , 2011, European journal of immunology.
[20] J. Sprent,et al. ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes , 2011, Nature Immunology.
[21] J. Sprent,et al. ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation , 2011, Nature immunology.
[22] Julian Downward,et al. RAS Interaction with PI3K: More Than Just Another Effector Pathway. , 2011, Genes & cancer.
[23] S. Desiderio,et al. Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. , 2011, Immunity.
[24] B. Beutler,et al. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow , 2011, Nature Immunology.
[25] T. Möröy,et al. Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. , 2010, Immunity.
[26] Greg M. Delgoffe,et al. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. , 2010, Immunity.
[27] D. Schatz,et al. Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. , 2010, Molecular cell.
[28] K. Okkenhaug,et al. The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development , 2010, Science Signaling.
[29] M. Mandal,et al. Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression , 2010, Molecular and Cellular Biology.
[30] B. Diamond,et al. Requirement for cyclin D3 in germinal center formation and function , 2010, Cell Research.
[31] A. Strasser,et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development , 2010, Nature Immunology.
[32] D. Allman,et al. c-Myb Is Required for Pro-B Cell Differentiation1 , 2009, The Journal of Immunology.
[33] C. Murre,et al. Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci , 2009, The Journal of experimental medicine.
[34] Harinder Singh,et al. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development , 2009, Nature Immunology.
[35] Elizabeth A. Kruse,et al. MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation , 2009, The Journal of Immunology.
[36] C. Schiff,et al. Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. , 2009, Blood.
[37] A. Cumano,et al. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7. , 2009, International immunology.
[38] M. Schlissel,et al. The effects of c-Abl mutation on developing B cell differentiation and survival. , 2009, International immunology.
[39] M. Reth,et al. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling , 2009, Nature Reviews Immunology.
[40] A. Feeney,et al. The Epigenetic Profile of Ig Genes Is Dynamically Regulated during B Cell Differentiation and Is Modulated by Pre-B Cell Receptor Signaling1 , 2009, The Journal of Immunology.
[41] O. Takeuchi,et al. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid , 2008, Proceedings of the National Academy of Sciences.
[42] H. Wardemann,et al. Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. , 2008, Immunity.
[43] D. Koller,et al. The Immunological Genome Project: networks of gene expression in immune cells , 2008, Nature Immunology.
[44] S. Jacobsen,et al. FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. , 2008, Blood.
[45] H. Jäck,et al. A Unique Role for the λ5 Nonimmunoglobulin Tail in Early B Lymphocyte Development1 , 2008, The Journal of Immunology.
[46] R. Månsson,et al. E2A proteins promote development of lymphoid-primed multipotent progenitors. , 2008, Immunity.
[47] A. de Riva,et al. Censoring of Autoreactive B Cell Development by the Pre-B Cell Receptor , 2008, Science.
[48] Ignacio A. Demarco,et al. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros , 2008, Nature Immunology.
[49] M. Schlissel,et al. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development , 2008, Nature Immunology.
[50] R. DePinho,et al. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway , 2008, Nature Immunology.
[51] H. Sanjo,et al. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. , 2008, Immunity.
[52] T. Hashimshony,et al. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. , 2008, Immunity.
[53] Jing Wang,et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes , 2008, Nature Immunology.
[54] E. Bertolino,et al. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 , 2008, Nature Immunology.
[55] T. Yamazaki,et al. Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. , 2008, Blood.
[56] S. Pathak,et al. Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development. , 2008, Blood.
[57] A. Koleske,et al. Defective T Cell Development and Function in the Absence of Abelson Kinases1 , 2007, The Journal of Immunology.
[58] R. Hendriks,et al. Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. , 2007, Immunity.
[59] J. Imler,et al. Dicing with viruses: microRNAs as antiviral factors. , 2007, Immunity.
[60] X. Dai,et al. Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing , 2007, Molecular and Cellular Biology.
[61] S. Nutt,et al. The transcriptional regulation of B cell lineage commitment. , 2007, Immunity.
[62] Koon-Guan Lee,et al. Combined deficiencies in Bruton tyrosine kinase and phospholipase Cgamma2 arrest B-cell development at a pre-BCR+ stage. , 2007, Blood.
[63] Mark M. Davis,et al. Structural Insight into Pre-B Cell Receptor Function , 2007, Science.
[64] A. Fisher,et al. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. , 2007, Immunity.
[65] H. Jumaa,et al. Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. , 2007, Immunity.
[66] Gillian E. Wu,et al. Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice. , 2007, International immunology.
[67] M. Turner,et al. Cutting Edge: The PI3K p110δ Is Required for Down-Regulation of RAG Expression in Immature B Cells1 , 2007, The Journal of Immunology.
[68] P. Wilson,et al. Igκ allelic inclusion is a consequence of receptor editing , 2007, The Journal of experimental medicine.
[69] M. Busslinger,et al. Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5 , 2006, Molecular and Cellular Biology.
[70] T. Chiles,et al. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. , 2006, Blood.
[71] P. Sicinski,et al. A unique function for cyclin D3 in early B cell development , 2006, Nature Immunology.
[72] C. Paige,et al. IL-7: a key regulator of B lymphopoiesis. , 2006, Seminars in immunology.
[73] Yuan Zhuang,et al. E2A and IRF-4/Pip Promote Chromatin Modification and Transcription of the Immunoglobulin κ Locus in Pre-B Cells , 2006, Molecular and Cellular Biology.
[74] L. Hennighausen,et al. Stat5a/b are essential for normal lymphoid development and differentiation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[75] T. Lebien,et al. Murine and Human IL-7 Activate STAT5 and Induce Proliferation of Normal Human Pro-B Cells1 , 2005, The Journal of Immunology.
[76] Cameron S. Osborne,et al. The pre‐B‐cell receptor induces silencing of VpreB and λ5 transcription , 2005 .
[77] J. Ihle,et al. Regulation of interleukin 7–dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5 , 2005, Nature Immunology.
[78] F. Melchers. The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire , 2005, Nature Reviews Immunology.
[79] S. Desiderio,et al. Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. , 2005, Molecular cell.
[80] Y. Zhuang,et al. New insights into E-protein function in lymphocyte development. , 2005, Trends in immunology.
[81] M. Kondo,et al. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF , 2005, The Journal of experimental medicine.
[82] M. Ciemerych,et al. Cell cycle in mouse development , 2005, Oncogene.
[83] Harinder Singh,et al. Contingent gene regulatory networks and B cell fate specification. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[84] E. Lam,et al. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells , 2005, Oncogene.
[85] Kong-Peng Lam,et al. Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells , 2005, PLoS biology.
[86] A. Fischer,et al. Interleukin‐7 receptor α (IL‐7Rα) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients , 2005, Immunological reviews.
[87] Yang Xu,et al. Important Roles for E Protein Binding Sites within the Immunoglobulin κ Chain Intronic Enhancer in Activating Vκ Jκ Rearrangement , 2004, The Journal of experimental medicine.
[88] Harinder Singh,et al. Assembling a gene regulatory network for specification of the B cell fate. , 2004, Developmental cell.
[89] Pierre Dubus,et al. Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6 , 2004, Cell.
[90] K. Akashi,et al. Mouse Development and Cell Proliferation in the Absence of D-Cyclins , 2004, Cell.
[91] M. Schlissel,et al. Regulation of activation and recombination of the murine Igκ locus , 2004 .
[92] A. Cumano,et al. Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[93] H. Young,et al. Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members , 2004, Molecular and Cellular Biology.
[94] Takashi Nagasawa,et al. Cellular niches controlling B lymphocyte behavior within bone marrow during development. , 2004, Immunity.
[95] M. Farrar,et al. STAT5 Activation Underlies IL7 Receptor-Dependent B Cell Development1 , 2004, The Journal of Immunology.
[96] R. Buckley. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. , 2004, Annual review of immunology.
[97] S. Korsmeyer,et al. Cell Death Critical Control Points , 2004, Cell.
[98] A. Ferrando,et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. , 2003, Cancer cell.
[99] M. Schlissel,et al. Regulating antigen-receptor gene assembly , 2003, Nature Reviews Immunology.
[100] David Botstein,et al. T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression , 2003, PLoS biology.
[101] P. Hammerman,et al. Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival , 2003, Molecular and Cellular Biology.
[102] H. Jäck,et al. Interaction of Murine Precursor B Cell Receptor with Stroma Cells Is Controlled by the Unique Tail of λ5 and Stroma Cell-Associated Heparan Sulfate 1 , 2003, The Journal of Immunology.
[103] F. Melchers,et al. The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling , 2003, Nature Immunology.
[104] Harinder Singh,et al. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. , 2003, Genes & development.
[105] S. Cook,et al. Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim* , 2003, Journal of Biological Chemistry.
[106] A. Strasser,et al. B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription. , 2002, Molecular cell.
[107] J. Ihle,et al. Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex , 2002, Molecular and Cellular Biology.
[108] Florence Roux,et al. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[109] E. Vigorito,et al. A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation , 2002, The Journal of experimental medicine.
[110] K. Okkenhaug,et al. Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice , 2002, Science.
[111] M. Nussenzweig,et al. B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-α and Ig-β1 , 2002, The Journal of Immunology.
[112] I. Mårtensson,et al. VpreB1/VpreB2/λ5 Triple-Deficient Mice Show Impaired B Cell Development but Functional Allelic Exclusion of the IgH Locus1 , 2002, The Journal of Immunology.
[113] H. Fleming,et al. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. , 2001, Immunity.
[114] E. Kandel,et al. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. , 2001, Genes & development.
[115] P. Zipfel,et al. The c-Abl Tyrosine Kinase Is Regulated Downstream of the B Cell Antigen Receptor and Interacts with CD191 , 2000, The Journal of Immunology.
[116] D. Nemazee,et al. Revising B Cell Receptors , 2000, The Journal of experimental medicine.
[117] C. Murre,et al. E2A proteins: essential regulators at multiple stages of B‐cell development , 2000, Immunological reviews.
[118] A. Rolink,et al. Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells , 2000, Immunological reviews.
[119] Wei Wei Wu,et al. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. , 2000, International immunology.
[120] E. Lam,et al. Cyclin D3 Compensates for Loss of Cyclin D2 in Mouse B-lymphocytes Activated via the Antigen Receptor and CD40* , 2000, The Journal of Biological Chemistry.
[121] A. Feeney,et al. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. , 2000, Molecular cell.
[122] T. Winkler,et al. Precursor B Cell Receptor–Dependent B Cell Proliferation and Differentiation Does Not Require the Bone Marrow or Fetal Liver Environment , 2000, The Journal of experimental medicine.
[123] S. Desiderio,et al. Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. , 1999, Immunity.
[124] R. Eisenman,et al. c-Myc enhances protein synthesis and cell size during B lymphocyte development. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[125] M. Reth,et al. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. , 1999, Immunity.
[126] James M. Roberts,et al. CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.
[127] F. Alt,et al. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[128] F. Alt,et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. , 1999, Science.
[129] Y. Yazaki,et al. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. , 1999, Science.
[130] F. Alt,et al. Activated Ras Signals Developmental Progression of Recombinase-activating Gene (RAG)-deficient Pro-B Lymphocytes , 1999, The Journal of experimental medicine.
[131] Steven F. Ziegler,et al. Defective IL7R expression in T-B+NK + severe combined immunodeficiency , 1998, Nature Genetics.
[132] M. Farrar,et al. Control of B cell development by Ras‐mediated activation of Raf , 1997, The EMBO journal.
[133] I. Weissman,et al. Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice , 1997 .
[134] S. Desiderio,et al. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. , 1996, Immunity.
[135] A. Shaffer,et al. Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro , 1996, Cell.
[136] Nobuyuki Shishido,et al. Mice Lacking p27 Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors , 1996, Cell.
[137] Michel C. Nussenzweig,et al. Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ , 1996, Science.
[138] M. Owen,et al. The interleukin‐7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. , 1996, The EMBO journal.
[139] F. Alt,et al. Bone marrow B lymphocyte development in c-abl-deficient mice. , 1995, Cellular immunology.
[140] R. Weichselbaum,et al. Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents , 1995, Nature.
[141] R. Grosschedl,et al. Failure of B-cell differentiation in mice lacking the transcription factor EBF , 1995, Nature.
[142] C. Ware,et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice , 1994, The Journal of experimental medicine.
[143] S. Jacobsen,et al. Stem cell factor and interleukin-7 synergize to enhance early myelopoiesis in vitro. , 1994, Blood.
[144] F. Alt,et al. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. , 1994, Genes & development.
[145] R. Bronson,et al. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene , 1991, Cell.
[146] Klaus Rajewsky,et al. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene , 1991, Nature.
[147] C. Schiff,et al. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. , 2011, Blood.
[148] M. Clark. Flippin' lipids , 2011, Nature Immunology.
[149] Ellen V. Rothenberg,et al. Launching the T-cell-lineage developmental programme , 2008, Nature Reviews Immunology.
[150] S. Akira,et al. Contribution of Receptor Editing to the Antibody Repertoire , 2007 .
[151] M. Llorian,et al. The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. , 2007, Journal of immunology.
[152] I. Aifantis,et al. The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms. , 2005, Current topics in microbiology and immunology.
[153] M. Reth,et al. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion , 2003, Nature Immunology.