论文信息 - Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric Restriction

Genetic studies of single gene mutations are revealing mechanisms and pathways that regulate longevity across distant species ([1][1]). One such mechanism is an alteration in histone deacetylase activity. Abolishing expression of the Rpd3 deacetylase ([2][2]) or increasing expression of the Sir2

[1] G. Reuter,et al. Suppressor mutation of position-effect variegation in Drosophila melanogaster affecting chromatin properties , 1986, Chromosoma.

[2] B. Rogina,et al. Extended life-span conferred by cotransporter gene mutations in Drosophila. , 2000, Science.

[3] Chi-Yung Lai,et al. Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. , 1999, Molecular biology of the cell.

[4] M. Levine,et al. The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[5] David B. Goldstein,et al. Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster , 2002, Current Biology.

[6] S. Benzer,et al. Life extension in Drosophila by feeding a drug , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[7] E. Hafen,et al. Dietary Restriction in Long-Lived Dwarf Flies , 2002, Science.