The capabilities of nanoelectronic 2-D materials for bio-inspired computing and drug delivery indicate their significance in modern drug design.

Remarkable advancements in the computational techniques and nanoelectronics have attracted considerable interests for development of highly-sophisticated materials (Ms) including the theranostics with optimal characteristics and innovative delivery systems. Analyzing the huge amounts of multivariate data and solving the newly-emerged complicated problems including the healthcare-related ones have created increasing demands for improving the computational speed and minimizing the consumption of energy. Shifting towards the non-von Neumann approaches enables performing specific computational tasks and optimizing the processing of signals. Besides usefulness for neuromorphic computing and increasing the efficiency of computation energy, 2-D electronic Ms are capable of optical sensing with ultra-fast and ultra-sensitive responses, mimicking the neurons, detection of pathogens or biomolecules, and prediction of the progression of diseases, assessment of the pharmacokinetics/pharmacodynamics of therapeutic candidates, mimicking the dynamics of the release of neurotransmitters or fluxes of ions that might provide a deeper knowledge about the computations and information flow in the brain, and development of more effective treatment protocols with improved outcomes. 2-D Ms appear as the major components of the next-generation electronically-enabled devices for highly-advanced computations, bio-imaging, diagnostics, tissue engineering, and designing smart systems for site-specific delivery of therapeutics that might result in the reduced adverse effects of drugs and improved patient compliance. This manuscript highlights the significance of 2-D Ms in the neuromorphic computing, optimizing the energy efficiency of the multi-step computations, providing novel architectures or multi-functional systems, improved performance of a variety of devices and bio-inspired functionalities, and delivery of theranostics.

[1]  Peng Lin,et al.  Fully memristive neural networks for pattern classification with unsupervised learning , 2018 .

[2]  Feng Xing,et al.  Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy , 2018, Proceedings of the National Academy of Sciences.

[3]  Yi Luo,et al.  All-optical machine learning using diffractive deep neural networks , 2018, Science.

[4]  Yu Chen,et al.  Biocompatible 2D Titanium Carbide (MXenes) Composite Nanosheets for pH-Responsive MRI-Guided Tumor Hyperthermia , 2017 .

[5]  Antonello Cutolo,et al.  Carbon nanotube acoustic and optical sensors for volatile organic compound detection , 2005 .

[6]  F. Atyabi,et al.  Application of carbon nanotubes as the carriers of the cannabinoid, 2‐arachidonoylglycerol: Towards a novel treatment strategy in colitis , 2017, Life sciences.

[7]  Jin-Young Jung,et al.  Efficient delivery of anticancer drug MTX through MTX-LDH nanohybrid system , 2006 .

[8]  Y. Pathak,et al.  Artificial Neural Network in Drug Delivery and Pharmaceutical Research , 2013 .

[9]  Ying-Wei Yang,et al.  Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy , 2017, Advanced materials.

[10]  Vladan Stevanović,et al.  Computationally guided discovery of thermoelectric materials , 2017 .

[11]  Kamal Choudhary,et al.  Machine learning with force-field inspired descriptors for materials: fast screening and mapping energy landscape. , 2018, Physical review materials.

[12]  Dmitry K. Polyushkin,et al.  Ultrafast machine vision with 2D material neural network image sensors , 2020, Nature.

[13]  K. Novoselov.  Nobel Lecture: Graphene: Materials in the Flatland , 2011 .

[14]  Michael M. Leane,et al.  The use of artificial neural networks for the selection of the most appropriate formulation and processing variables in order to predict the in vitro dissolution of sustained release minitablets , 2003, AAPS PharmSciTech.

[15]  K. Novoselov,et al.  Magnetic 2D materials and heterostructures , 2019, Nature Nanotechnology.

[16]  Tao Wu,et al.  Integration of machine learning approaches for accelerated discovery of transition-metal dichalcogenides as Hg0 sensing materials , 2019 .

[17]  P. Hassanzadeh.  Nanopharmaceuticals: Innovative theranostics for the neurological disorders , 2014 .

[18]  Lianzhou Wang,et al.  Recent advances in 2D materials for photocatalysis. , 2016, Nanoscale.

[19]  Ji-Seon Lee,et al.  Functional manganese dioxide nanosheet for targeted photodynamic therapy and bioimaging in vitro and in vivo , 2017 .

[20]  Mahaveer D. Kurkuri,et al.  Nanodiamonds and their surface modification strategies for drug delivery applications , 2020 .

[21]  Parichehr Hassanzadeh,et al.  Computational modelling: moonlighting on the neuroscience and medicine , 2013 .

[22]  Andrew Pannone,et al.  Gaussian synapses for probabilistic neural networks , 2019, Nature Communications.

[23]  Han Lin,et al.  Two-Dimensional Tantalum Carbide (MXenes) Composite Nanosheets for Multiple Imaging-Guided Photothermal Tumor Ablation. , 2017, ACS nano.

[24]  Hyunsang Hwang,et al.  TiOx-Based RRAM Synapse With 64-Levels of Conductance and Symmetric Conductance Change by Adopting a Hybrid Pulse Scheme for Neuromorphic Computing , 2016, IEEE Electron Device Letters.

[25]  Paul S Weiss.  Welcome to ACS Nano. , 2007, ACS nano.

[26]  F. Atyabi,et al.  Aerosol delivery of ferulic acid-loaded nanostructured lipid carriers: A promising treatment approach against the respiratory disorders , 2017 .

[27]  Dmitri B. Strukov,et al.  Implementation of multilayer perceptron network with highly uniform passive memristive crossbar circuits , 2017, Nature Communications.

[28]  F. Atyabi,et al.  Nerve growth factor‐carbon nanotube complex exerts prolonged protective effects in an in vitro model of ischemic stroke , 2017, Life sciences.

[29]  L. Chua.  Memristor, Hodgkin–Huxley, and Edge of Chaos , 2013, Nanotechnology.

[30]  A C Evans,et al.  Biocomputing nanoplatforms as therapeutics and diagnostics. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[31]  P. Hassanzadeh.  The significance of bioengineered nanoplatforms against SARS-CoV-2: From detection to genome editing , 2021, Life Sciences.

[32]  N. Shahabadi,et al.  Biological application of Layered double hydroxides in drug delivery systems , 2018 .

[33]  P. Hassanzadeh.  Tissue engineering and growth factors: updated evidence , 2012 .

[34]  Rassoul Dinarvand,et al.  Linkers: The key elements for the creation of efficient nanotherapeutics , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[35]  Qiming Zhang,et al.  Artificial neural networks enabled by nanophotonics , 2019, Light: Science & Applications.

[36]  David-Wei Zhang,et al.  A MoS2/PTCDA Hybrid Heterojunction Synapse with Efficient Photoelectric Dual Modulation and Versatility , 2018, Advanced materials.

[37]  M. Hersam,et al.  Multi-terminal memtransistors from polycrystalline monolayer molybdenum disulfide , 2018, Nature.

[38]  Phil Mestecky,et al.  What is materials chemistry , 1998 .

[39]  Ondrej Dyck,et al.  Deep learning analysis of defect and phase evolution during electron beam-induced transformations in WS2 , 2018, npj Computational Materials.

[40]  A. Gaharwar,et al.  Two‐Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects , 2015, Advanced materials.

[41]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[42]  Aspects of Nanoelectronics in Materials Development , 2016 .

[43]  Sergei V. Kalinin,et al.  Quantitative Analysis of the Local Phase Transitions Induced by Laser Heating. , 2015, ACS nano.

[44]  Lei Shen,et al.  2DMatPedia, an open computational database of two-dimensional materials from top-down and bottom-up approaches , 2019, Scientific Data.

[45]  Tobin J Marks,et al.  Hybrid, Gate-Tunable, van der Waals p-n Heterojunctions from Pentacene and MoS2. , 2016, Nano letters.

[46]  F. Atyabi,et al.  Ferulic acid‐loaded nanostructured lipid carriers: A promising nanoformulation against the ischemic neural injuries , 2018, Life sciences.

[47]  Jun Wang,et al.  A versatile neuromorphic system based on simple neuron model , 2019 .

[48]  Rassoul Dinarvand,et al.  Application of modelling and nanotechnology‐based approaches: The emergence of breakthroughs in theranostics of central nervous system disorders , 2017, Life sciences.

[49]  Xianfan Xu,et al.  Phosphorene: an unexplored 2D semiconductor with a high hole mobility. , 2014, ACS nano.

[50]  Anirban Sen Gupta,et al.  Photodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[51]  Hong Guo,et al.  Discovery of Novel Two-Dimensional Photovoltaic Materials Accelerated by Machine Learning. , 2020, The journal of physical chemistry letters.

[52]  Raj Kishore,et al.  A nature inspired modularity function for unsupervised learning involving spatially embedded networks , 2019, Scientific Reports.

[53]  George G. Malliaras,et al.  Neuromorphic device architectures with global connectivity through electrolyte gating , 2017, Nature Communications.

[54]  Pritish Narayanan,et al.  Equivalent-accuracy accelerated neural-network training using analogue memory , 2018, Nature.

[55]  Fu Wang,et al.  Double-carrier drug delivery system based on polyurethane-polyvinyl alcohol/layered double hydroxide nanocomposite hydrogel , 2019, Materials Letters.

[56]  D. Fan,et al.  Two-Dimensional MXene (Ti3C2)-Integrated Cellulose Hydrogels: Toward Smart Three-Dimensional Network Nanoplatforms Exhibiting Light-Induced Swelling and Bimodal Photothermal/Chemotherapy Anticancer Activity. , 2018, ACS applied materials & interfaces.

[57]  F. Atyabi,et al.  Ferulic acid, a phenolic compound with therapeutic effects in neuropsychiatric disorders, stimulates the production of nerve growth factor and endocannabinoids in rat brain , 2017 .

[58]  Peng Qiao,et al.  Effect of organically intercalation modified layered double hydroxides-graphene oxide hybrids on flame retardancy of thermoplastic polyurethane nanocomposites , 2020, Journal of Thermal Analysis and Calorimetry.

[59]  Liang Cheng,et al.  2D Nanomaterials for Cancer Theranostic Applications , 2019, Advanced materials.

[60]  Yanli Zhao,et al.  Fabrication of PEGylated graphitic carbon nitride quantum dots as traceable, pH-sensitive drug delivery systems , 2018 .

[61]  F. Atyabi,et al.  Carbon nanotubes provide longer lasting gastroprotective effects for anandamide in stress-induced gastric ulcer in rat , 2018 .

[62]  Andrew S. Cassidy,et al.  A million spiking-neuron integrated circuit with a scalable communication network and interface , 2014, Science.

[63]  Lei Zhang,et al.  Memristive devices based on emerging two-dimensional materials beyond graphene. , 2019, Nanoscale.

[64]  E. Eleftheriou,et al.  All-memristive neuromorphic computing with level-tuned neurons , 2016, Nanotechnology.

[65]  M. Dragoman,et al.  2D Materials Nanoelectronics: New Concepts, Fabrication, Characterization From Microwaves up to Optical Spectrum , 2019, physica status solidi (a).

[66]  Haifei Wang,et al.  A Versatile Platform Based on Black Phosphorus Nanosheets with Enhanced Stability for Cancer Synergistic Therapy. , 2018, Journal of biomedical nanotechnology.

[67]  Lei Wang,et al.  Synergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO2 nanosheets , 2019, Drug delivery.

[68]  Wei Huang,et al.  Controllable Multiple Depression in a Graphene Oxide Artificial Synapse , 2017 .

[69]  M. Papi,et al.  Graphene oxide touches blood: in vivo interactions of bio-coronated 2D materials. , 2019, Nanoscale horizons.

[70]  Hyunsang Hwang,et al.  Organic core-sheath nanowire artificial synapses with femtojoule energy consumption , 2016, Science Advances.

[71]  Toru Maekawa,et al.  Graphene based biosensors—Accelerating medical diagnostics to new-dimensions , 2017 .

[72]  Han Lin,et al.  A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows. , 2017, Journal of the American Chemical Society.

[73]  Seongjun Park,et al.  Two-terminal floating-gate memory with van der Waals heterostructures for ultrahigh on/off ratio , 2016, Nature Communications.

[74]  Rassoul Dinarvand,et al.  Ignoring the modeling approaches: Towards the shadowy paths in nanomedicine , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[75]  Mark C Hersam,et al.  Electronic Transport in Two-Dimensional Materials. , 2018, Annual review of physical chemistry.

[76]  Katsuhiko Ariga,et al.  Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery. , 2017, ACS applied materials & interfaces.

[77]  A. Holban,et al.  Applications of Nanodiamonds in the Detection and Therapy of Infectious Diseases , 2019, Materials.

[78]  Surya R. Kalidindi,et al.  Materials informatics , 2018, Journal of Intelligent Manufacturing.

[79]  Young Sun,et al.  All‐Solid‐State Synaptic Transistor with Ultralow Conductance for Neuromorphic Computing , 2018, Advanced Functional Materials.

[80]  Kamal Choudhary,et al.  High-throughput Identification and Characterization of Two-dimensional Materials using Density functional theory , 2017, Scientific Reports.

[81]  Wei Lu,et al.  Abnormal Multiple Charge Memory States in Exfoliated Few-Layer WSe2 Transistors. , 2017, ACS nano.

[82]  H-S Philip Wong,et al.  Artificial optic-neural synapse for colored and color-mixed pattern recognition , 2018, Nature Communications.

[83]  John Youshia,et al.  Artificial neural network based particle size prediction of polymeric nanoparticles , 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[84]  Ryan P. Adams,et al.  Design of efficient molecular organic light-emitting diodes by a high-throughput virtual screening and experimental approach. , 2016, Nature materials.

[85]  Rassoul Dinarvand,et al.  The significance of artificial intelligence in drug delivery system design. , 2019, Advanced drug delivery reviews.

[86]  L. Yao,et al.  Antimicrobial effect of surgical masks coated with nanoparticles. , 2006, The Journal of hospital infection.

[87]  Saptarshi Das,et al.  Mimicking Neurotransmitter Release in Chemical Synapses via Hysteresis Engineering in MoS2 Transistors. , 2017, ACS nano.

[88]  K. Sun,et al.  Memristive Behavior and Ideal Memristor of 1T Phase MoS2 Nanosheets. , 2016, Nano letters.

[89]  Yuriy V. Pershin,et al.  Memory effects in complex materials and nanoscale systems , 2010, 1011.3053.

[90]  C. Pannecouque,et al.  Graphene Quantum Dots Based Systems As HIV Inhibitors. , 2018, Bioconjugate chemistry.

[91]  M. Hussein,et al.  Chlorogenic acid intercalated Gadolinium–Zinc/Aluminium layered double hydroxide and gold nanohybrid for MR imaging and drug delivery , 2020 .

[92]  Jaesung Jang,et al.  Low cost synthesis of reduced graphene oxide using biopolymer for influenza virus sensor. , 2020, Materials science & engineering. C, Materials for biological applications.

[93]  O. Vaughan.  Nanoparticle surfactants: In a jam , 2013 .

[94]  Qing Wan,et al.  2D MoS2 Neuromorphic Devices for Brain-Like Computational Systems. , 2017, Small.

[95]  Ali Khiat,et al.  Memristive synapses connect brain and silicon spiking neurons , 2020, Scientific Reports.

[96]  Yu Chen,et al.  Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion. , 2017, Nano letters.

[97]  Nagarajan Raghavan,et al.  Recommended Methods to Study Resistive Switching Devices , 2018, Advanced Electronic Materials.

[98]  Jun Lin,et al.  Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2–Pt@Au25 nanosheets , 2019, Chemical Engineering Journal.

[99]  Qingsheng Zeng,et al.  Black Phosphorus Nanosheets: Synthesis, Characterization and Applications. , 2016, Small.

[100]  H. Park,et al.  Black Phosphorus (BP) Nanodots for Potential Biomedical Applications. , 2016, Small.

[101]  Yongqiang Dong,et al.  Graphitic Carbon Nitride Materials: Sensing, Imaging and Therapy. , 2016, Small.

[102]  P. Hassanzadeh.  New perspectives in biosensor technology , 2010 .

[103]  Gang Wei,et al.  Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review. , 2019, Materials science & engineering. C, Materials for biological applications.

[104]  Young Sun,et al.  A Synaptic Transistor based on Quasi‐2D Molybdenum Oxide , 2017, Advanced materials.

[105]  Sungi Kim,et al.  Nano-bio-computing lipid nanotablet , 2019, Science Advances.

[106]  Rassoul Dinarvand,et al.  Creation of Nanorobots: Both State-of-the-Science and State-of-the-Art , 2017 .

[107]  F. Atyabi,et al.  Carbon nanotubes prolong the regulatory action of nerve growth factor on the endocannabinoid signaling , 2015 .

[108]  R. O’Reilly.  Biologically Based Computational Models of High-Level Cognition , 2006, Science.

[109]  Y. Agrawal,et al.  A Study of the Behavior of HNT with DNA Intercalator Acridine Orange , 2013 .

[110]  Y. Gogotsi,et al.  Antimicrobial Properties of 2D MnO2 and MoS2 Nanomaterials Vertically Aligned on Graphene Materials and Ti3C2 MXene. , 2018, Langmuir : the ACS journal of surfaces and colloids.

[111]  Subhasish Mitra,et al.  Three-dimensional integration of nanotechnologies for computing and data storage on a single chip , 2017, Nature.

[112]  Leon O. Chua,et al.  Neuromemristive Circuits for Edge Computing: A Review , 2018, IEEE Transactions on Neural Networks and Learning Systems.

[113]  F. Atyabi,et al.  Nanoencapsulation: A Promising Strategy for Biomedical Applications of Ferulic Acid , 2018 .

[114]  Rajeev J. Ram,et al.  Single-chip microprocessor that communicates directly using light , 2015, Nature.

[115]  D. Choi,et al.  Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease , 2018, Drug delivery.

[116]  R. Sarid,et al.  Graphene-Based "Hot Plate" for the Capture and Destruction of the Herpes Simplex Virus Type 1. , 2017, Bioconjugate chemistry.

[117]  Daniel W. Davies,et al.  Machine learning for molecular and materials science , 2018, Nature.

[118]  Myungsoo Kim,et al.  Atomristor: Nonvolatile Resistance Switching in Atomic Sheets of Transition Metal Dichalcogenides. , 2018, Nano letters.

[119]  Yuchao Yang,et al.  Ion Gated Synaptic Transistors Based on 2D van der Waals Crystals with Tunable Diffusive Dynamics , 2018, Advanced materials.

[120]  Mahaveer D. Kurkuri,et al.  Nature engineered diatom biosilica as drug delivery systems , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[121]  R. Haag,et al.  Size-dependent inhibition of herpesvirus cellular entry by polyvalent nanoarchitectures. , 2017, Nanoscale.

[122]  R S Evans,et al.  Electronic Health Records: Then, Now, and in the Future , 2016, Yearbook of Medical Informatics.

[123]  P. Schwaller,et al.  Two-dimensional materials from high-throughput computational exfoliation of experimentally known compounds , 2016, Nature Nanotechnology.

[124]  Rajesh Vadlapatla,et al.  Electronic drug delivery systems: An overview , 2017 .

[125]  Jang-Sik Lee,et al.  Short-Term Plasticity and Long-Term Potentiation in Artificial Biosynapses with Diffusive Dynamics. , 2018, ACS nano.

[126]  Chongwu Zhou,et al.  Aligned Carbon Nanotube Synaptic Transistors for Large-Scale Neuromorphic Computing. , 2018, ACS nano.

[127]  Anju Surendranath,et al.  2D materials for next generation healthcare applications , 2018, International journal of pharmaceutics.

[128]  Zaiyao Fei,et al.  Ferroelectric switching of a two-dimensional metal , 2018, Nature.

[129]  Meng He,et al.  Artificial Synapses Emulated by an Electrolyte‐Gated Tungsten‐Oxide Transistor , 2018, Advanced materials.

[130]  D. Bradley,et al.  Nano-crater morphology in hybrid electron-collecting buffer layers for high efficiency polymer:nonfullerene solar cells with enhanced stability. , 2019, Nanoscale horizons.

[131]  Chun‐Sing Lee,et al.  Graphitic carbon nitride nanosheet@metal-organic framework core-shell nanoparticles for photo-chemo combination therapy. , 2015, Nanoscale.

[132]  O. Akhavan,et al.  Protein Degradation and RNA Efflux of Viruses Photocatalyzed by Graphene–Tungsten Oxide Composite Under Visible Light Irradiation , 2012 .

[133]  Jan M. Rabaey,et al.  Hyperdimensional Computing Exploiting Carbon Nanotube FETs, Resistive RAM, and Their Monolithic 3D Integration , 2018, IEEE Journal of Solid-State Circuits.

[134]  Gopal Chakrabarti,et al.  Nano‐Structures as Bioelectronics for Controlled Drug Delivery , 2021 .

[135]  Q. Vu,et al.  Two‐Terminal Multibit Optical Memory via van der Waals Heterostructure , 2018, Advanced materials.

[136]  Zhenan Bao,et al.  A bioinspired flexible organic artificial afferent nerve , 2018, Science.

[137]  Sungho Kim,et al.  Pattern Recognition Using Carbon Nanotube Synaptic Transistors with an Adjustable Weight Update Protocol. , 2017, ACS nano.

[138]  Lianzhou Wang,et al.  Unique physicochemical properties of two-dimensional light absorbers facilitating photocatalysis. , 2018, Chemical Society reviews.

[139]  Weijun Peng,et al.  Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation. , 2018, Biomaterials.

[140]  V. K. Rai,et al.  Novel drug delivery system: an immense hope for diabetics , 2016, Drug delivery.

[141]  Jian Sun,et al.  Deep Residual Learning for Image Recognition , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[142]  Eric Pop,et al.  Electronic synapses made of layered two-dimensional materials , 2018, Nature Electronics.

[143]  Sujan Kumar Gonugondla,et al.  A Variation-Tolerant In-Memory Machine Learning Classifier via On-Chip Training , 2018, IEEE Journal of Solid-State Circuits.

[144]  Farnood Merrikh-Bayat,et al.  High-Performance Mixed-Signal Neurocomputing With Nanoscale Floating-Gate Memory Cell Arrays , 2018, IEEE Transactions on Neural Networks and Learning Systems.

[145]  G. Malliaras.  Organic electrochemical transistors , 2020 .

[146]  D. Jeong,et al.  Memristors for Energy‐Efficient New Computing Paradigms , 2016 .

[147]  Yu Huang,et al.  Van der Waals integration before and beyond two-dimensional materials , 2019, Nature.

[148]  Qiang Li,et al.  Engineering Optical Absorption in Graphene and Other 2D Materials: Advances and Applications , 2019, Advanced Optical Materials.

[149]  Deji Akinwande,et al.  Two-dimensional flexible nanoelectronics , 2014, Nature Communications.

[150]  F. Xia,et al.  Anisotropic Black Phosphorus Synaptic Device for Neuromorphic Applications , 2016, Advanced materials.

[151]  He Tian,et al.  High Performance 2D Perovskite/Graphene Optical Synapses as Artificial Eyes , 2018, 2018 IEEE International Electron Devices Meeting (IEDM).

[152]  Patrick Couvreur,et al.  Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. , 2012, Chemical reviews.

[153]  Rajiv K. Kalia,et al.  Hybrid finite-element/molecular-dynamics/electronic-density-functional approach to materials simulations on parallel computers , 2001 .

[154]  Qing Hua Wang,et al.  Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. , 2012, Nature nanotechnology.

[155]  Takashi Taniguchi,et al.  Spin Lifetimes Exceeding 12 ns in Graphene Nonlocal Spin Valve Devices. , 2016, Nano letters.

[156]  He Shen,et al.  Biomedical Applications of Graphene , 2012, Theranostics.

[157]  Shimeng Yu,et al.  Neuro-Inspired Computing With Emerging Nonvolatile Memorys , 2018, Proceedings of the IEEE.

[158]  H Ge,et al.  Tissue Engineering Scheming by Artificial Intelligence , 2005, The International journal of artificial organs.

[159]  J.I. Ababneh,et al.  Simple model for quantum-dot semiconductor optical amplifiers using artificial neural networks , 2006, IEEE Transactions on Electron Devices.

[160]  Y. Agrawal,et al.  Interaction Behavior of DNA with Halloysite Nanotube–Silver Nanoparticle-Based Composite , 2013 .

[161]  Yingchun Li,et al.  Recent advances of two-dimensional materials in smart drug delivery nano-systems , 2020, Bioactive materials.

[162]  Hossein Valavi,et al.  A 64-Tile 2.4-Mb In-Memory-Computing CNN Accelerator Employing Charge-Domain Compute , 2019, IEEE Journal of Solid-State Circuits.

[163]  J. Yang,et al.  Memristors with diffusive dynamics as synaptic emulators for neuromorphic computing. , 2017, Nature materials.

[164]  Liang Cheng,et al.  Drug Delivery with PEGylated MoS2 Nano‐sheets for Combined Photothermal and Chemotherapy of Cancer , 2014, Advanced materials.

[165]  Donhee Ham,et al.  Vertical MoS2 Double-Layer Memristor with Electrochemical Metallization as an Atomic-Scale Synapse with Switching Thresholds Approaching 100 mV. , 2019, Nano letters.

[166]  A. Amani,et al.  Concurrent study of stability and cytotoxicity of a novel nanoemulsion system – an artificial neural networks approach , 2017, Pharmaceutical development and technology.

[167]  Byoungil Lee,et al.  Nanoelectronic programmable synapses based on phase change materials for brain-inspired computing. , 2012, Nano letters.

[168]  Yongsuk Choi,et al.  Multibit MoS2 Photoelectronic Memory with Ultrahigh Sensitivity , 2016, Advanced materials.

[169]  Zibiao Li,et al.  Functionalization of 2D transition metal dichalcogenides for biomedical applications. , 2017, Materials science & engineering. C, Materials for biological applications.

[170]  Yury Gogotsi,et al.  The Rise of MXenes. , 2019, ACS nano.

[171]  Geoffrey W. Burr,et al.  Nanoscale electronic synapses using phase change devices , 2013, JETC.

[172]  Sujan Kumar Gonugondla,et al.  A Multi-Functional In-Memory Inference Processor Using a Standard 6T SRAM Array , 2018, IEEE Journal of Solid-State Circuits.

[173]  M. Grimm,et al.  Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System. , 2015, Journal of pharmaceutical sciences.

[174]  Armantas Melianas,et al.  Parallel programming of an ionic floating-gate memory array for scalable neuromorphic computing , 2019, Science.

[175]  J. Zou,et al.  Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy. , 2017, ACS applied materials & interfaces.

[176]  P. Hassanzadeh.  Nanotheranostics against COVID-19: From multivalent to immune-targeted materials , 2020, Journal of Controlled Release.

[177]  Michael Pfeiffer,et al.  Deep Learning With Spiking Neurons: Opportunities and Challenges , 2018, Front. Neurosci..

[178]  J Joshua Yang,et al.  Memristive devices for computing. , 2013, Nature nanotechnology.

[179]  Shimeng Yu,et al.  Emerging Memory Technologies: Recent Trends and Prospects , 2016, IEEE Solid-State Circuits Magazine.

[180]  Daniele Ielmini,et al.  Surface diffusion-limited lifetime of silver and copper nanofilaments in resistive switching devices , 2019, Nature Communications.

[181]  Wei D. Lu,et al.  Ionic modulation and ionic coupling effects in MoS2 devices for neuromorphic computing , 2018, Nature Materials.

[182]  P. Prasad,et al.  Photonics and optoelectronics using nano-structured hybrid perovskite media and their optical cavities , 2019, Physics Reports.

[183]  K. Ang,et al.  2D photonic memristor beyond graphene: progress and prospects , 2020, Nanophotonics.

[184]  Arnan Mitchell,et al.  Two dimensional and layered transition metal oxides , 2016 .

[185]  Bin Wu,et al.  MoS2 Memristors Exhibiting Variable Switching Characteristics toward Biorealistic Synaptic Emulation. , 2018, ACS nano.

[186]  Hua Zhang,et al.  Two-dimensional semiconductors for transistors , 2016 .

[187]  Yong Gan,et al.  Optimization and Evaluation of Time-Dependent Tablets Comprising an Immediate and Sustained Release Profile Using Artificial Neural Network , 2008 .

[188]  Shimeng Yu,et al.  Three-Dimensional nand Flash for Vector–Matrix Multiplication , 2019, IEEE Transactions on Very Large Scale Integration (VLSI) Systems.

[189]  C. David Wright,et al.  In-memory computing on a photonic platform , 2018, Science Advances.

[190]  Yang Hui Liu,et al.  Flexible Metal Oxide/Graphene Oxide Hybrid Neuromorphic Transistors on Flexible Conducting Graphene Substrates , 2016, Advanced materials.

[191]  A. Szuplewska,et al.  2D Ti2C (MXene) as a novel highly efficient and selective agent for photothermal therapy. , 2019, Materials science & engineering. C, Materials for biological applications.

[192]  Xuebin Wang,et al.  Highly water-soluble, porous, and biocompatible boron nitrides for anticancer drug delivery. , 2014, ACS nano.

[193]  Krishna Rajan,et al.  Application-Driven Data Analysis , 2009 .

[194]  Arindam Basu,et al.  Synergistic Gating of Electro‐Iono‐Photoactive 2D Chalcogenide Neuristors: Coexistence of Hebbian and Homeostatic Synaptic Metaplasticity , 2018, Advanced materials.

[195]  Kamal Choudhary,et al.  High-throughput assessment of vacancy formation and surface energies of materials using classical force-fields , 2018, Journal of physics. Condensed matter : an Institute of Physics journal.

[196]  Jianxiu Wang,et al.  Black phosphorus nanosheets-based nanocarriers for enhancing chemotherapy drug sensitiveness via depleting mutant p53 and resistant cancer multimodal therapy , 2019, Chemical Engineering Journal.

[197]  F. Liu,et al.  High-Performance Photoinduced Memory with Ultrafast Charge Transfer Based on MoS2 /SWCNTs Network Van Der Waals Heterostructure. , 2018, Small.

[198]  Han Zhang,et al.  Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics , 2017, Advanced materials.

[199]  Rassoul Dinarvand,et al.  Tissue engineering: Still facing a long way ahead , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[200]  Bing Chen,et al.  A general memristor-based partial differential equation solver , 2018, Nature Electronics.

[201]  Bin Su,et al.  DNA-based intelligent logic controlled release systems. , 2012, Chemical communications.

[202]  J. Yang,et al.  Robust memristors based on layered two-dimensional materials , 2018, 1801.00530.

[203]  Yusuf Leblebici,et al.  Neuromorphic computing with multi-memristive synapses , 2017, Nature Communications.

[204]  F. Atyabi,et al.  Application of nanostructured lipid carriers: the prolonged protective effects for sesamol in in vitro and in vivo models of ischemic stroke via activation of PI3K signalling pathway , 2017, DARU Journal of Pharmaceutical Sciences.

[205]  Richard J. Duro,et al.  Gaussian synapse ANNs in multi- and hyperspectral image data analysis , 2003, IEEE Trans. Instrum. Meas..

[206]  Parichehr Hassanzadeh,et al.  Towards the quantum-enabled technologies for development of drugs or delivery systems. , 2020, Journal of controlled release : official journal of the Controlled Release Society.

[207]  Sungjoo Lee,et al.  2D–Organic Hybrid Heterostructures for Optoelectronic Applications , 2019, Advanced materials.

[208]  Michael A. McGuire,et al.  Giant tunneling magnetoresistance in spin-filter van der Waals heterostructures , 2018, Science.

[209]  Kyung-Hwa Yoo,et al.  Artificial Synaptic Emulators Based on MoS2 Flash Memory Devices with Double Floating Gates. , 2018, ACS applied materials & interfaces.

[210]  Bai-Sun Kong,et al.  Self-selective van der Waals heterostructures for large scale memory array , 2019, Nature Communications.

[211]  S. Chattopadhyay,et al.  Utilization of nanoporous biosilica of diatoms as a potential source material for fabrication of nanoelectronic device and their characterization , 2020, Journal of Applied Phycology.

[212]  Stephen Jesse,et al.  Identification of phases, symmetries and defects through local crystallography , 2015, Nature Communications.

[213]  J. Yang,et al.  Memristive crossbar arrays for brain-inspired computing , 2019, Nature Materials.

[214]  Zhigang Wang,et al.  2D Ultrathin MXene‐Based Drug‐Delivery Nanoplatform for Synergistic Photothermal Ablation and Chemotherapy of Cancer , 2018, Advanced healthcare materials.

[215]  R. Xiao,et al.  Hypericin-loaded graphene oxide protects ducks against a novel duck reovirus. , 2019, Materials science & engineering. C, Materials for biological applications.

[216]  R. Zeineldin.  Cancer Nanotechnology , 2017, Methods in Molecular Biology.

[217]  Sergei V. Kalinin,et al.  Building and exploring libraries of atomic defects in graphene: Scanning transmission electron and scanning tunneling microscopy study , 2018, Science Advances.

[218]  Zheng Fang,et al.  In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer. , 2019, Journal of photochemistry and photobiology. B, Biology.

[219]  Yi Yang,et al.  Graphene Dynamic Synapse with Modulatable Plasticity. , 2015, Nano letters.

[220]  Xin Huang,et al.  Artificial Synapses Based on Multiterminal Memtransistors for Neuromorphic Application , 2019, Advanced Functional Materials.

[221]  R. Tang,et al.  Virus capture and destruction by label-free graphene oxide for detection and disinfection applications. , 2015, Small.

[222]  S. Roche,et al.  Room-Temperature Spin Hall Effect in Graphene/MoS2 van der Waals Heterostructures. , 2018, Nano letters.

[223]  Juwon Lee,et al.  Monolayer optical memory cells based on artificial trap-mediated charge storage and release , 2017, Nature Communications.

[224]  S. Xiao,et al.  Antiviral Activity of Graphene Oxide-Silver Nanocomposites by Preventing Viral Entry and Activation of the Antiviral Innate Immune Response. , 2018, ACS applied bio materials.

[225]  Minshen Zhu,et al.  Photoluminescent Ti3C2 MXene Quantum Dots for Multicolor Cellular Imaging , 2017, Advanced materials.

[226]  Lei Fang,et al.  Multifunctional Carboxymethyl Chitosan Derivatives-Layered Double Hydroxides Hybrid Nanocomposites for Efficient Drug Delivery to the Posterior Segment of the Eye , 2020, Acta biomaterialia.

[227]  Kunnyun Kim,et al.  A High‐On/Off‐Ratio Floating‐Gate Memristor Array on a Flexible Substrate via CVD‐Grown Large‐Area 2D Layer Stacking , 2017, Advanced materials.

[228]  Nguyen T. K. Thanh,et al.  Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties. , 2018, Nanoscale.

[229]  Siddharth Joshi,et al.  Author Correction: Ferroelectric ternary content-addressable memory for one-shot learning , 2019, Nature Electronics.

[230]  Anantha P. Chandrakasan,et al.  CONV-SRAM: An Energy-Efficient SRAM With In-Memory Dot-Product Computation for Low-Power Convolutional Neural Networks , 2019, IEEE Journal of Solid-State Circuits.

[231]  Seyong Oh,et al.  Recent Progress in Artificial Synapses Based on Two-Dimensional van der Waals Materials for Brain-Inspired Computing , 2020 .

[232]  F. Guinea,et al.  Colloquium : Spintronics in graphene and other two-dimensional materials , 2019, Reviews of Modern Physics.

[233]  Erin Antono,et al.  Overcoming data scarcity with transfer learning , 2017, ArXiv.

[234]  F. Wang,et al.  Two dimensional hexagonal boron nitride (2D-hBN): synthesis, properties and applications , 2017 .

[235]  J. Turnbull,et al.  The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding , 2020, bioRxiv.

[236]  M. Dubey,et al.  Dynamically reconfigurable electronic and phononic properties in intercalated HfS2 , 2020 .

[237]  Kristofer G. Reyes,et al.  Prediction of Nanoscale Friction for Two-Dimensional Materials Using a Machine Learning Approach , 2020, Tribology Letters.