Classification of prostatic biopsy

Prostatic biopsies provide the information for the determined diagnosis of prostatic cancer. Computer-aid investigation of biopsies can reduce the loading of pathologists and also inter- and intra-observer variability as well. In this paper, we proposed a novel method to classify prostatic biopsies according to the Gleason Grading System. This method analyzes the fractal dimension of sub-bands derived from the images of prostatic biopsies. In the experiments, we adopted Support vector machine as the classifier and the leave-one-out approach to estimate error rate. The present experimental results demonstrated that 86.3% of accuracy for a set of 1000 pathological images. These images are randomly selected from 50 cases which were prepared within last five years.

[1]  Irini Reljin,et al.  Adaptation of multifractal analysis to segmentation of microcalcifications in digital mammograms , 2006 .

[2]  Po-Whei Huang,et al.  Automatic Classification for Pathological Prostate Images Based on Fractal Analysis , 2009, IEEE Transactions on Medical Imaging.

[3]  Mikhail Teverovskiy,et al.  Automated prostate cancer diagnosis and Gleason grading of tissue microarrays , 2005, SPIE Medical Imaging.

[4]  Benoit B. Mandelbrot,et al.  Fractal Geometry of Nature , 1984 .

[5]  Bidyut Baran Chaudhuri,et al.  Texture Segmentation Using Fractal Dimension , 1995, IEEE Trans. Pattern Anal. Mach. Intell..

[6]  P H Bartels,et al.  A hybrid neural and statistical classifier system for histopathologic grading of prostatic lesions. , 1995, Analytical and quantitative cytology and histology.

[7]  K. N. Dollman,et al.  - 1 , 1743 .

[8]  Jianming Lu,et al.  Texture Classification for Liver Tissues from Ultrasonic B-Scan Images Using Testified PNN , 2006, IEICE Trans. Inf. Syst..

[9]  John R. Gilbertson,et al.  Evaluation of prostate tumor grades by content-based image retrieval , 1999, Other Conferences.

[10]  David G. Bostwick,et al.  The Gleason Score: A Significant Biologic Manifestation of Prostate Cancer Aggressiveness On Biopsy , 2001 .

[11]  Michael Werman,et al.  Similarity Measurement Method for the Classification of Architecturally Differentiated Images , 1999, Comput. Biomed. Res..

[12]  Paul Wintz,et al.  Digital image processing (2nd ed.) , 1987 .

[13]  G. Bubley,et al.  Biology of prostate-specific antigen. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  Hamid Soltanian-Zadeh,et al.  Multiwavelet grading of pathological images of prostate , 2003, IEEE Transactions on Biomedical Engineering.

[15]  Yung-Chang Chen,et al.  Ultrasonic Liver Tissues Classification by Fractal Feature Vector Based on M-band Wavelet Transform , 2001, IEEE Trans. Medical Imaging.

[16]  R. Voss Random Fractals: characterization and measurement , 1991 .

[17]  Nirupam Sarkar,et al.  An Efficient Differential Box-Counting Approach to Compute Fractal Dimension of Image , 1994, IEEE Trans. Syst. Man Cybern. Syst..

[18]  J. Hornaday,et al.  Cancer Facts & Figures 2004 , 2004 .

[19]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.