Comparison of continuous and intermittent vibration effects on rat‐tail artery and nerve

Hand‐transmitted vibration from powered‐tools can cause peripheral vasospasm and neuropathy. A rat‐tail model was used to investigate whether the pattern of vibration influenced the type and severity of tissue damage. The tails of awake rats were vibrated continuously or intermittently for a total of 4 hours at 60 HZ, 49 m/s2. Nerves and arteries were harvested immediately or 24 hours after treatment. Tails subjected to intermittent vibration showed transiently increased sensitivity to thermal stimuli. Intermittent vibration caused the most nerve injury immediately and 24 hours after vibration. Continuous vibration invoked a persistent reduction in vascular lumen size. Compared to epinephrine‐induced transient vacuolation in vascular smooth muscle cells, both continuous and intermittent vibration caused greater persistence of vacuoles, indicating a vibration‐induced pathological process. All vibration groups exhibited elevated nitrotyrosine immunoreactivity indicative of free‐radical damage. Pattern of vibration exposure may exert a major influence on the type of vibration injury. Muscle Nerve, 2006

[1]  R. F. Rushmer,et al.  Architecture of Small Arteries during Vasoconstriction , 1962, Circulation research.

[2]  I Pyykkö,et al.  The prevalence and symptoms of traumatic vasospastic disease among lumberjacks in Finland. A field study. , 1974, Work, environment, health.

[3]  G. Majno,et al.  Cell-to-cell herniae in the arterial wall. I. The pathogenesis of vacuoles in the normal media. , 1977, The American journal of pathology.

[4]  C. Welsh,et al.  The effect of vibration on digital blood flow , 1980, The British journal of surgery.

[5]  G. Majno,et al.  Medial changes in arterial spasm induced by L-norepinephrine. , 1981, The American journal of pathology.

[6]  A. Okada.  Physiological response of the rat to different vibration frequencies. , 1986, Scandinavian journal of work, environment & health.

[7]  Vascular responses to acute vibration in the fingers of normal subjects. , 1995, Central European journal of public health.

[8]  M J Griffin,et al.  Measurement, evaluation, and assessment of occupational exposures to hand-transmitted vibration. , 1997, Occupational and environmental medicine.

[9]  Massimo Bovenzi,et al.  Exposure-response relationship in the hand-arm vibration syndrome: an overview of current epidemiology research , 1998, International archives of occupational and environmental health.

[10]  M J Griffin,et al.  Duration of acute exposures to vibration and finger circulation. , 1998, Scandinavian journal of work, environment & health.

[11]  H. Sakakibara,et al.  Effect of vibration magnitude and repetitive exposure on finger blood flow in healthy subjects , 2000, International archives of occupational and environmental health.

[12]  Danny A Riley,et al.  Vibration injury damages arterial endothelial cells , 2002, Muscle & nerve.

[13]  J. Slot,et al.  Expression of Inducible Nitric-oxide Synthase and Intracellular Protein Tyrosine Nitration in Vascular Smooth Muscle Cells , 2003, Journal of Biological Chemistry.

[14]  J. Eichberg.  Myelin P0: New Knowledge and New Roles , 2002, Neurochemical Research.

[15]  Kevin C. Smith,et al.  Vibration anesthesia: a noninvasive method of reducing discomfort prior to dermatologic procedures. , 2004, Dermatology online journal.

[16]  T. Howard,et al.  Exposure of Rat Optic Nerves to Nitric Oxide Causes Protein S-Nitrosation and Myelin Decompaction , 2004, Neurochemical Research.

[17]  Ulrich Pohl,et al.  Acute mechanoadaptation of vascular smooth muscle cells in response to continuous arteriolar vasoconstriction: implications for functional remodeling , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Michael J Griffin,et al.  Acute effects of continuous and intermittent vibration on finger circulation , 2004, International archives of occupational and environmental health.

[19]  H. Matloub,et al.  Nifedipine pretreatment reduces vibration‐induced vascular damage , 2005, Muscle & nerve.

[20]  H. Matloub,et al.  Evidence for frequency-dependent arterial damage in vibrated rat tails. , 2005, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[21]  D. Riley,et al.  Effects of temperature on vibration‐induced damage in nerves and arteries , 2006, Muscle & nerve.