Multibiodose Radiation Emergency Triage Categorization Software

AbstractIn this note, the authors describe the MULTIBIODOSE software, which has been created as part of the MULTIBIODOSE project. The software enables doses estimated by networks of laboratories, using up to five retrospective (biological and physical) assays, to be combined to give a single estimate of triage category for each individual potentially exposed to ionizing radiation in a large scale radiation accident or incident. The MULTIBIODOSE software has been created in Java. The usage of the software is based on the MULTIBIODOSE Guidance: the program creates a link to a single SQLite database for each incident, and the database is administered by the lead laboratory. The software has been tested with Java runtime environment 6 and 7 on a number of different Windows, Mac, and Linux systems, using data from a recent intercomparison exercise. The Java program MULTIBIODOSE_1.0.jar is freely available to download from http://www.multibiodose.eu/software or by contacting the software administrator: MULTIBIODOSE-software@gmx.com.

[1]  François Trompier,et al.  Radiation-induced signals analysed by EPR spectrometry applied to fortuitous dosimetry. , 2009, Annali dell'Istituto superiore di sanita.

[2]  Emad A. Ahmed,et al.  Persistent DNA Damage after High Dose In Vivo Gamma Exposure of Minipig Skin , 2012, PloS one.

[3]  Emanuela Bortolin,et al.  Radiation-induced damage analysed by luminescence methods in retrospective dosimetry and emergency response. , 2009, Annali dell'Istituto superiore di sanita.

[4]  Jian Zhang,et al.  THE RABIT: A RAPID AUTOMATED BIODOSIMETRY TOOL FOR RADIOLOGICAL TRIAGE , 2010, Health physics.

[5]  O. Guipaud.  Serum and plasma proteomics and its possible use as detector and predictor of radiation diseases. , 2013, Advances in Experimental Medicine and Biology.

[6]  William F. Blakely,et al.  Amylase and blood cell-count hematological radiation-injury biomarkers in a rhesus monkey radiation model—use of multiparameter and integrated biological dosimetry , 2007 .

[7]  F Trompier,et al.  Realising the European Network of Biodosimetry (RENEB). , 2012, Radiation protection dosimetry.

[8]  Elizabeth A Ainsbury,et al.  Inter- and intra-laboratory comparison of a multibiodosimetric approach to triage in a simulated, large scale radiation emergency , 2014, International journal of radiation biology.

[9]  Ruth C. Wilkins,et al.  Biological Dosimetry by the Triage Dicentric Chromosome Assay: Potential Implications for Treatment of Acute Radiation Syndrome in Radiological Mass Casualties , 2011, Radiation research.

[10]  J F Barquinero,et al.  Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents. , 2013, Mutation research.

[11]  Z Carr,et al.  The capacity, capabilities and needs of the WHO BioDoseNet member laboratories. , 2012, Radiation protection dosimetry.

[12]  Hubert Thierens,et al.  Automated micronucleus (MN) scoring for population triage in case of large scale radiation events , 2010, International journal of radiation biology.

[13]  Elizabeth A Ainsbury,et al.  Manual versus automated γ-H2AX foci analysis across five European laboratories: can this assay be used for rapid biodosimetry in a large scale radiation accident? , 2013, Mutation research.