Effects of butylated hydroxyanisole and butylated hydroxytoluene on DNA adduct formation and arylamines N-acetyltransferase activity in PC-3 cells (human prostate tumor) in vitro.

[1]  G. Williams,et al.  Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[2]  J. Chung Paeonol promotion of DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumour cells. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  G. Williams,et al.  Inhibition of the hepatocarcinogenicity of aflatoxin B1 in rats by low levels of the phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene. , 1996, Cancer letters.

[4]  D. Bell,et al.  Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. , 1995, Cancer research.

[5]  W. Weber,et al.  2-Aminofluorene metabolism and DNA adduct formation by mononuclear leukocytes from rapid and slow acetylator mouse strains. , 1994, Carcinogenesis.

[6]  J G Chung,et al.  Distribution of 2-aminofluorene and p-aminobenzoic acid N-acetyltransferase activity in tissues of C57BL/6J rapid and B6.A-NatS slow acetylator congenic mice. , 1993, Drug metabolism and disposition: the biological fate of chemicals.

[7]  D. Grant,et al.  Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. , 1993, Carcinogenesis.

[8]  G. Levy DNA-carcinogen adducts in circulating leukocytes as indicators of arylamine carcinogen exposure. , 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[9]  R. Minchin,et al.  N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. , 1992, Biochemical and biophysical research communications.

[10]  A. Ghosal,et al.  Enhancement by butylated hydroxytoluene of the in vitro activation of 3,3'-dichlorobenzidine. , 1992, Mutation research.

[11]  G. Chader,et al.  Partial purification and characterization of arylamine N-acetyltransferase in bovine retina. , 1992, Current Eye Research.

[12]  W. Weber,et al.  Diverse point mutations in the human gene for polymorphic N-acetyltransferase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Ishidate,et al.  Mutagenicity of 30 chemicals in Salmonella typhimurium strains possessing different nitroreductase or O-acetyltransferase activities. , 1991, Mutation research.

[14]  T. Deguchi,et al.  Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver. , 1990, The Journal of biological chemistry.

[15]  D. Grant,et al.  Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. , 1990, DNA and cell biology.

[16]  G. Williams,et al.  Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. I. Genetic and cellular effects. , 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[17]  M. Marion,et al.  Inhibition of binding of 2-acetylaminofluorene to DNA by butylated hydroxytoluene and butylated hydroxyanisole in vitro. , 1989, Cancer letters.

[18]  P. K. Brady,et al.  Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol. , 1989, Cancer research.

[19]  W. Weber,et al.  High-performance liquid chromatographic analysis of 32P-postlabeled DNA-aromatic carcinogen adducts. , 1988, Analytical biochemistry.

[20]  D. Hein Acetylator genotype and arylamine-induced carcinogenesis. , 1988, Biochimica et biophysica acta.

[21]  J. Chipman,et al.  Reduction of 2-acetylaminofluorene-induced unscheduled DNA synthesis in human and rat hepatocytes by butylated hydroxytoluene. , 1988, Mutation research.

[22]  K. Inai,et al.  Hepatocellular Tumorigenicity of Butylated Hydroxytoluene Administered Orally to B6C3F1 Mice , 1988, Japanese journal of cancer research : Gann.

[23]  P. Pour,et al.  Induction of prostatic carcinomas and lower urinary tract neoplasms by combined treatment of intact and castrated rats with testosterone propionate and N-nitrosobis(2-oxopropyl)amine. , 1987, Cancer research.

[24]  W. Weber The acetylator genes and drug response , 1987 .

[25]  N Ito,et al.  Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis. , 1986, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[26]  D. C. Kirkpatrick,et al.  Intake of phenolic antioxidants from foods in Canada. , 1986, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[27]  T. Kamataki,et al.  Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity. , 1986, Cancer research.

[28]  G. Williams,et al.  Dose-related inhibition of aflatoxin B1 induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene. , 1986, Carcinogenesis.

[29]  W. Weber,et al.  N-acetylation pharmacogenetics. , 1985, Pharmacological reviews.

[30]  G. Williams,et al.  Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene. , 1984, Cancer research.

[31]  G. Williams,et al.  Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats. , 1984, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[32]  R. Cartwright Historical and modern epidemiological studies on populations exposed to N-substituted aryl compounds. , 1983, Environmental health perspectives.

[33]  R. Glashan,et al.  ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER , 1982, The Lancet.

[34]  T. Slaga,et al.  The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase. , 1977, Cancer research.

[35]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.