Ketone compounds synthesis method - one kind [3,2-c] pyridine (5H) -4-furan

The invention relates to a method for synthesizing a furan[3,2-c] pyridine-4(5H) ketone compound, and belongs to the technical field of organic synthesis. The conventional synthetic method has the defects of complex synthetic steps, rigor reaction condition, high synthetic cost, low yield and few substituted groups and functional groups of the obtained products and the defect that the raw materials are not easily obtained. The method is characterized by comprising the following steps of: 1, mixing N,N-dimethylformamide (DMF) and triflate anhydride (Tf2O) at normal temperature in a molar ratioof (10-150):1, and stirring for 2 to 10 minutes; and 2, adding a cyclopropyl amide compound in an amount which is 0.3 to 1.0 molar time that of the triflate anhydride, heating to the temperature of between 70 and 120 DEG C, and stirring for 0.2 to 3.0 hours to generate the furan[3,2-c] pyridine-4(5H) ketone compound serving as a final product. The substituted groups and functional groups of the product are more, and the product can be used as an intermediate to participate in organic synthetic reaction further; and the synthetic cost is reduced substantially, and the yield is improved substantially.