Three-Dimensional Single-Photon Emission Computed Tomography Using Cone Beam Collimation (CB-SPECT)

A simple and economically practical method of improving the sensitivity of camera-based SPECT was developed using converging (cone-beam) collimation. This geometry is particularly advantageous for SPECT devices using large field-of-view cameras in imaging smaller, centrally located activity distributions. Geometric sensitivities, spatial resolutions, and fields-of-view of a cone-beam collimator having a focal length of 48 cm and a similarly designed parallel hole collimator were compared analytically. At 15 cm from the collimator surface the point-source sensitivity of the cone-beam collimator was 2.4 times the sensitivity of the parallel-hole collimator. SPECT projection data (simulated using Monte Carlo methodology) were reconstructed using a 3-D filtered backprojection algorithm. Cone-beam emission CT (CE-SPECT) seems potentially useful for animal investigations, pediatric studies, and for brain imaging.

[1]  Ronald J. Jaszczak,et al.  Single Photon Emission Computed Tomography Using Multi-Slice Fan Beam Collimators , 1979, IEEE Transactions on Nuclear Science.

[2]  N. Lassen,et al.  A single photon dynamic computer assisted tomograph (DCAT) for imaging brain function in multiple cross sections. , 1980, Journal of computer assisted tomography.

[3]  Richard A. Holmes,et al.  Missouri University Multi-Plane Imager (MUMPI): A high sensitivity rapid dynamic ECT brain imager , 1984 .

[4]  R J Jaszczak,et al.  Whole-body single-photon emission computed tomography using dual, large-field-of-view scintillation cameras , 1979, Physics in medicine and biology.

[5]  Ronald J. Jaszczak,et al.  Analysis of SPECT including Scatter and Attenuation Using Sophisticated Monte Carlo Modeling Methods , 1982, IEEE Transactions on Nuclear Science.

[6]  L. Feldkamp,et al.  Practical cone-beam algorithm , 1984 .

[7]  K F Koral,et al.  Performance evaluation of SPRINT, a single photon ring tomography for brain imaging. , 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  R. Q. Edwards,et al.  The Mark IV system for radionuclide computed tomography of the brain. , 1976, Radiology.

[9]  Z. Cho,et al.  Performance of Single Photon Tomographic System - GAMMATOM-1 , 1982, IEEE Transactions on Nuclear Science.

[10]  H. Stoddart,et al.  A New Development in Single Gamma Transaxial Tomography Union Carbide Focused Collimator Scanner , 1979, IEEE Transactions on Nuclear Science.

[11]  R. Moyer.  A low-energy multihole converging collimator compared with a pinhole collimator. , 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  W. Oldendorf,et al.  N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain. , 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  J. Keyes,et al.  An optimized collimator for single-photon computed tomography with a scintillation camera. , 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.