论文信息 - Microbiological transformation of piperidine and pyridine derivatives

Microbiological transformation of piperidine and pyridine derivatives

Optically active 2-(4-hydroxyphenylcarbamoyloxymethyl)-1-methyl-1,2,5,6-tetrahydropyridine is obtained on microbiological transformation of 1-methyl-2-(N-phenyl-carbamoyloxymethyl)-1,2,5,6-tetrahydropyridine with a growing culture of the fungus C. verticillata VKPM F-430. Transformation of 2-(2-phenylethyl)pyridine by a methanoxidating culture of Methylococcus occurs either by hydroxylation of the side chain or conversion of the substrate into N-oxide, depending on the process conditions.

[1] C. Cerniglia,et al. Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans , 1996, Applied and environmental microbiology.

[2] D. K. Kim,et al. Preparation of optically active 3-substituted piperidines via ring expansion: synthesis of 4-amino- and 4-fluoro-1,4,5-trideoxy-1,5-imino-D-ribitol and 1,5-dideoxy-1,5-imino-D-ribitol , 1996 .

[3] R. Furstoss,et al. “Microbial transformations 18. Regiospecific para-hydroxylation of aromatic carbamates mediated by the fungus Beauveria sulfurescens” , 1991 .

[4] B. Waegell,et al. Microbiological transformations 2. Hydroxylations of non activated carbons in globular type amides. , 1981 .

[5] B. Waegell,et al. Microbiological transformations: Hydroxylation of non activated carbons in bridged bicyclic amides. , 1980 .

[6] W. Moodie,et al. A synthetic route to 3,7-disubstituted bicyclo[3.3.2]decanes , 1975 .

[7] C. Tilford,et al. Histamine antagonists; basically substituted pyridine derivatives. , 1948, Journal of the American Chemical Society.